TNF alpha Protein (AA 78-234) (His tag)

N° du produit ABIN1047832

Détail du produit

Antigène: TNF alpha (Tumor Necrosis Factor alpha (TNF alpha))

Type de proteíne: Recombinant

Attributs du protein: AA 78-234

Origine: Boeuf (Vache)

Source: Escherichia coli (E. coli)

Purification/Conjugué: Cette TNF alpha protéine est marqué à la His tag.

Application: SDS-PAGE (SDS), ELISA

Séquence: LRSSSQASSN KPVAHVVADI NSPGQLRWWD SYANALMANG VKLEDNQLVV PADGLYLIYS QVLFRGQGCP STPLFLTHTI SRIAVSYQTK VNILSAIKSP CHRETPEWAE AKPWYEPIYQ GGVFQLEKGD RLSAEINLPD YLDYAESGQV YFGIIAL

Attributs du produit: Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation.

Pureté: 95 %

Information d'application

Commentaires:

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Buffer: 20mM Tris-Hcl, 0.5M NaCl, 10% glycerin, PH 8.0, 200 mM Imidazole

Stock: -20 °C

Référence

Dietz, Neibergs, Womack, Kehrli: "Rapid communication: single strand conformational polymorphism (SSCP) of bovine tumor necrosis factor alpha." dans: Journal of animal science, Vol. 75, Issue 9, pp. 2567, (1997) (PubMed).

Mertens, Muriuki, Gaidulis: "Cloning of two members of the TNF-superfamily in cattle: CD40 ligand and tumor necrosis factor alpha." dans: Immunogenetics, Vol. 42, Issue 5, pp. 430-1, (1995) (PubMed).

Détail du antigène

Antigène: TNF alpha (Tumor Necrosis Factor alpha (TNF alpha))

Autre désignation: Tumor necrosis factor (TNF alpha Produits)

Synonymes: DIF Protein, TNF-alpha Protein, TNFA Protein, TNFSF2 Protein, RATTNF Protein, Tnfa Protein, tnf Protein, TNF-a Protein, TNFalpha Protein, Tnfsf1a Protein, TNFa Protein, cTNF Protein, Tnf-alpha Protein, tnfa-like Protein, TNF-ALPHA Protein, dif Protein, tnfa Protein, xtnf Protein, tnfsf2 Protein, tnf-alpha Protein, Cachectin Protein, tumor necrosis factor Protein, tumor necrosis factor b (TNF superfamily, member 2) Protein, tumor necrosis factor alpha Protein, tumor necrosis factor a (TNF superfamily, member 2) Protein, TNF Protein, Tnf Protein, tnf Protein, tnfb Protein, tnf-alpha Protein, LOC103694380 Protein, tnfa Protein

Sujet: Synonyms: Cachectin,TNF-alpha,Tumor necrosis factor ligand superfamily member 2,TNF-a

Poids moléculaire: 21.5 kD

UniProt: Q06599

Pathways: Signalisation NF-kappaB, Apoptose, Caspase Cascade in Apoptosis, Signalisation TLR, Cellular Response to Molecule of Bacterial Origin, Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, Production of Molecular Mediator of Immune Response, Positive Regulation of Endopeptidase Activity, Hepatitis C, Protein targeting to Nucleus, Inflammasome