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MICA Protein (AA 24-308) (His tag)

MICA Origine: Humain Hôte: HEK-293 Cells Recombinant >95 % as determined by SDS-PAGE.
N° du produit ABIN2181502
  • Antigène Voir toutes MICA Protéines
    MICA (MHC Class I Polypeptide-Related Sequence A (MICA))
    Type de proteíne
    Recombinant
    Attributs du protein
    AA 24-308
    Origine
    • 23
    • 1
    Humain
    Source
    • 12
    • 5
    • 4
    • 2
    • 1
    HEK-293 Cells
    Purification/Conjugué
    Cette MICA protéine est marqué à la His tag.
    Séquence
    AA 24-308
    Attributs du produit
    This protein carries a polyhistidine tag at the C-terminus. The protein has a calculated MW of 33.6 kDa. The protein migrates as 45-65 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
    Pureté
    >95 % as determined by SDS-PAGE.
    Stérilité
    0.22 μm filtered
    niveau d'endotoxine
    Less than 1.0 EU per μg by the LAL method.
    Top Product
    Discover our top product MICA Protéine
  • Restrictions
    For Research Use only
  • Format
    Lyophilized
    Buffer
    PBS, pH 7.4
    Conseil sur la manipulation
    Please avoid repeated freeze-thaw cycles.
    Stock
    -20 °C
    Stockage commentaire
    No activity loss was observed after storage at: In lyophilized state for 1 year (4 °C), After reconstitution under sterile conditions for 3 months (-70 °C).
  • Srpan, Ambrose, Karampatzakis, Saeed, Cartwright, Guldevall, De Matos, Önfelt, Davis: "Shedding of CD16 disassembles the NK cell immune synapse and boosts serial engagement of target cells." dans: The Journal of cell biology, Vol. 217, Issue 9, pp. 3267-3283, (2018) (PubMed).

  • Antigène
    MICA (MHC Class I Polypeptide-Related Sequence A (MICA))
    Autre désignation
    MICA (MICA Produits)
    Synonymes
    MIC-A Protein, PERB11.1 Protein, MHC class I polypeptide-related sequence A Protein, MICA Protein
    Sujet
    MHC class I polypeptide-related sequence A (MICA) belongs to the MHC class I family and MIC subfamily. MICA contains one Ig-like C1-type (immunoglobulin-like) domain. Unlike classical MHC class I molecules, MICA does not form a heterodimer with beta-2-microglobulin. MICA acts as a stress-induced self-antigen that is recognized by gamma delta T-cells. MICA is ligand for the KLRK1/NKG2D receptor. MICA bind to KLRK1 leads to cell lysis.
    Poids moléculaire
    33.8 kDa
    Pathways
    Activation of Innate immune Response, Transition Metal Ion Homeostasis
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