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Pertussis Toxin Protein (ARTC)

ARTC Origine: Bordetella pertussis Hôte: Bordetella pertussis Native Func Active
N° du produit ABIN2452202
  • Antigène Tous les produits Pertussis Toxin (ARTC)
    Pertussis Toxin (ARTC)
    Type de proteíne
    Native
    Activité biologique
    Active
    Origine
    Bordetella pertussis
    Source
    Bordetella pertussis
    Application
    Functional Studies (Func)
    Attributs du produit
    This product was highly purified (>90 % pure) from Bordetella pertussis strain Tohama by the method of Skelton & Wong. Cytotoxicity of the PT was confirmed by morphological alteration of CHO cells after treatment with 0.1 ng/mL of PT.
  • Indications d'application
    1. Studies on the signal transduction of the trimeric GTP binding proteins.
    2. Therapeutic role in treating a number of diseases including hypertention,viral and autoimumune inhibitions.
    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    83 µg/mL
    Buffer
    10 % glycerol, 10 mM phoshate buffer ( pH 7. 4), 137 mM NaCl
    Stock
    -80 °C
  • Skelton, Wong: "Simple, efficient purification of filamentous hemagglutinin and pertussis toxin from Bordetella pertussis by hydrophobic and affinity interaction." dans: Journal of clinical microbiology, Vol. 28, Issue 5, pp. 1062-5, (1990) (PubMed).

  • Antigène
    Pertussis Toxin (ARTC)
    Autre désignation
    Pertussis Toxin (ARTC Produits)
    Sujet
    Perrtussis toxin (PT) is a protein-based AB5-type exotoxin produced by Bordeterra pertussis. PT catalyzes the ADP-ribosylation of the alpha subunits of the heterotrimeric guanine nucleotide regulatory proteins Gi, Go, and Gt and prevents intracellular signal transduction involving the G proteins. PT consists of one moplecule of each S1 (26 kDa), S2 (22 kDa), S3 (22 kDa), S5 (12 kDa) and two molecule of S4 (12 kDa).
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