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IL-9 Protein (AA 19-144)

IL9 Origine: Souris Hôte: Cellules d'insectes Recombinant > 95 % , as determined by Coomassie stained SDS-PAGE. FACS Active
N° du produit ABIN2666533
  • Antigène Voir toutes IL-9 (IL9) Protéines
    IL-9 (IL9) (Interleukin 9 (IL9))
    Type de proteíne
    Recombinant
    Activité biologique
    Active
    Attributs du protein
    AA 19-144
    Origine
    • 18
    • 8
    • 4
    • 2
    • 2
    • 1
    • 1
    Souris
    Source
    • 14
    • 14
    • 4
    • 1
    • 1
    • 1
    • 1
    Cellules d'insectes
    Application
    Flow Cytometry (FACS)
    Pureté
    > 95 % , as determined by Coomassie stained SDS-PAGE.
    Stérilité
    0.22 μm filtered
    niveau d'endotoxine

    Less than 0.1 EU per μg of protein as determine by the LAL method.

    Top Product
    Discover our top product IL9 Protéine
  • Indications d'application
    Optimal working dilution should be determined by the investigator.
    Commentaires

    Biological activity: Mouse IL-9 induces proliferation of MO7e cells. The ED50 is 0.04 - 0.16 ng/ml, corresponding to a specific activity of 6.5 - 25.0 x 106 units/mg.

    Restrictions
    For Research Use only
  • Format
    Liquid
    Reconstitution
    For maximum results, quick spin vial prior to opening. Stock solutions can also be prepared at 50 - 100 μg/mL in sterile buffer (PBS, HPBS, DPBS, or EBSS) containing carrier protein such as 0.2 - 1 % BSA or HSA and stored in working aliquots at -20 °C to -70 °C.
    Buffer
    0.22 μm filtered protein solution is in PBS.
    Conseil sur la manipulation
    Avoid repeated freeze/thaw cycles.
    Stock
    -20 °C
    Stockage commentaire
    Unopened vial can be stored between 2°C and 8°C for one month, at -20°C for six months, or at -70°C for one year.
  • Antigène
    IL-9 (IL9) (Interleukin 9 (IL9))
    Autre désignation
    IL-9 (IL9 Produits)
    Synonymes
    IL9 Protein, IL-9 Protein, Il-9 Protein, P40 Protein, HP40 Protein, interleukin 9 Protein, IL9 Protein, il9 Protein, Il9 Protein
    Sujet
    IL-9 was initially identified in mice as a T cell growth factor. Human and murine IL-9 show 56 % amino acid sequence homology. IL-9 is a cytokine that acts as a regulator of a variety of hematopoietic cells, stimulates cell proliferation, and prevents apoptosis. The IL-9 receptor consists of the cytokine-specific IL-9 receptor α-chain (IL-9Rα) and the common γ-chain that is shared by IL-2, IL-4, IL-7, IL-15 and IL-21. IL-9 is expressed by activated Th9, Th17, Treg, and mast cells and appears to play important roles in the development and function of subsets within the CD4+ T cell lineage. IL-9 also inhibits immune responses by enhancing the suppressive properties of Tregs and by recruiting immune suppressive mast cells to sites of inflammation. Genetic studies on a mouse model of asthma demonstrated that this cytokine is a key factor in the pathogenesis of bronchial hyperresponsiveness. In this sense, it has been described that IL-9 and IL-9R expression are increased in lungs of asthmatic patients. In addition, IL-9 promotes mast cell mediated intestinal permeability and plays a role in the development of food allergies. Also, IL-9 has been associated with atopic dermatitis.
    Poids moléculaire
    The 125 amino acid recombinant protein has a predicted molecular mass of approximately 14 kDa. The DTT-reduced protein migrate as multiple bands between 17-25 kDa by SDS-PAGE due to different glycosylation. The predicted N-terminal amino acid is Gln.
    Pathways
    Signalistation JAK/STAT
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