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the ubiquitous tissue distribution of NHA2 suggests that H(+)-coupled transport is more widespread. The coexistence of Na(+) and H(+)-driven chemiosmotic circuits has implications for salt and pH regulation in the kidney.
NHA-oc/NHA2 displays the expected activities of a bona fide cation-proton antiporter and plays a key role(s) in normal osteoclast differentiation and function
Na+/H+ antiporter (Montrer SLC9A1 Kits ELISA) genes may contribute to sodium-lithium countertransport activity and salt homeostasis in humans[NHA1 (Montrer NHEDC1 Kits ELISA) and NHA2]
Data suggest that dietary salt elevates NHA2 expression in the nephron; NHA2 expression is localized apically to distal convoluted tubules and connecting tubules in the nephron; NHA2 expression in the nephron partially overlaps in distribution with V-type ATPase (Montrer DNAH8 Kits ELISA).
data revealed that NHA1 (Montrer NHEDC1 Kits ELISA) and NHA2 function as a key sodium-hydrogen exchanger (Montrer SLC9A3R2 Kits ELISA) responsible for sperm motility after leaving the cauda epididymidis.
Data indicate a critical role of the endosomal sodium/hydrogen exchanger (Montrer SLC9A3R2 Kits ELISA) NHA2 for clathrin-mediated endocytosis and insulin (Montrer INS Kits ELISA) secretion in beta-cells.
Data show evidence that NHEDC2 regulates osteoclastogenesis, an exhaustive analysis shows that Nhedc2GT/GT mice have no defect in osteoclast formation or function in vitro or in vivo.
These data from NHA2-deficient mice suggest that NHA2 is dispensable for osteoclast differentiation and bone resorption both in vitro and in vivo.
nha-oc is expressed by terminally differentiated osteoclasts.
Sodium hydrogen antiporters, such as NHEDC2, convert the proton motive force established by the respiratory chain or the F1F0 mitochondrial ATPase into sodium gradients that drive other energy-requiring processes, transduce environmental signals into cell responses, or function in drug efflux (Xiang et al., 2007
Na+/H+ exchanger domain containing 2
, mitochondrial sodium/hydrogen exchanger 9B2
, NHE domain-containing protein 2
, Na(+)/H(+) exchanger-like domain-containing protein 2
, mitochondrial Na(+)/H(+) exchanger NHA2
, mitochondrial sodium/hydrogen exchanger NHA2
, sodium/hydrogen exchanger-like domain-containing protein 2
, solute carrier family 9 subfamily B member 2
, solute carrier family 9, subfamily B (cation proton antiporter 2), member 2