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Rat (Rattus) UCP1 Kit ELISA pour Sandwich ELISA - ABIN435429
Rodríguez-Jimnez, Alastrue-Agudo, Erceg, Stojkovic, Moreno-Manzano: FM19G11 favors spinal cord injury regeneration and stem cell self-renewal by mitochondrial uncoupling and glucose metabolism induction. dans Stem cells (Dayton, Ohio) 2012
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Human UCP1 Kit ELISA pour Sandwich ELISA - ABIN421175
Spaethling, Sanchez-Alavez, Lee, Xia, Dueck, Wang, Fisher, Sul, Seale, Kim, Bartfai, Eberwine: Single-cell transcriptomics and functional target validation of brown adipocytes show their complex roles in metabolic homeostasis. dans FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2016
The transcriptome of overexpressing plants revealed a broad induction of stress-responsive genes not strictly related to the mitochondrial antioxidant machinery, suggesting that overexpression of AtUCP1 imposes a strong stress response within the cell.
Foliar NO3 (-) assimilation was enhanced in both aox1a and ucp1 compared with the wild-type, suggesting that foliar NO3 (-) assimilation is probably driven by a decreased capacity of mAET and an increase in reductant within the cytosol.
Overexpression of UCP1 in the mitochondrial inner membrane induced increased uncoupling respiration, decreased reactive pxygen species accumulation under abiotic stresses, and diminished cellular ATP content.
The main physiological role of UCP1 in Arabidopsis leaves is related to maintaining the redox poise of the mitochondrial electron transport chain to facilitate photosynthetic metabolism. [AtUCP1]
Data indicate that the abundance of uncoupling protein 1 (UCP1) was significantly reduced in the intrauterine growth restriction (IUGR) piglets.
An alignment with human UCP1 revealed that exons 3 to 5 were eliminated by a deletion in the pig sequence.
We observed that clozapine but not six other antipsychotic drugs reprogrammed the gene expression pattern of differentiating human adipocytes ex vivo, leading to an elevated expression of the browning marker gene UCP1, more and smaller lipid droplets and more mitochondrial DNA than in the untreated white adipocytes.
The GG genotype of the UCP1-3826 A/G polymorphism appears to contribute to the onset of childhood obesity in Turkish children. The GG genotype of UCP1, together with the del/del genotype of the UCP2 (Montrer UCP2 Kits ELISA) polymorphism, may increase the risk of obesity with synergistic effects. The ins (Montrer INS Kits ELISA) allele of the UCP2 (Montrer UCP2 Kits ELISA) exon 8 del/ins (Montrer INS Kits ELISA) polymorphism may contribute to low HDL (Montrer HSD11B1 Kits ELISA) cholesterolemia.
TENM2 (Montrer TENM2 Kits ELISA) knockdown induces both UCP1 mRNA and protein expression upon adipogenic differentiation without affecting mitochondrial mass.
The role of UCP1 gene polymorphisms A-3826G, A-1766G, Met229Leu and Ala64Thr in susceptibility to obesity or metabolic syndrome was reviewed.
Haplotype-based interaction between the PPARGC1A (Montrer PPARGC1A Kits ELISA) and UCP1 genes is associated with impaired fasting glucose (IFG (Montrer IFNG Kits ELISA)) or type 2 diabetes mellitus (T2DM) among the residents of Henan province, China. Individuals with the haplotype AAG (Montrer MPG Kits ELISA) (PPARGC1A (Montrer PPARGC1A Kits ELISA) gene) and CTCG (UCP1 gene) have increased susceptibility to IFG (Montrer IFNG Kits ELISA) or T2DM, while those with haplotype AAG (Montrer MPG Kits ELISA) (PPARGC1A (Montrer PPARGC1A Kits ELISA) gene) and CTCA (UCP1 gene) have a lower risk of IFG (Montrer IFNG Kits ELISA) or T2DM.
human and rodent Brown adipose tissue have similar UCP1 function per mitochondrion.
glucocorticoids increased isoprenaline-stimulated respiration and UCP-1 in human primary brown adipocytes.
These results reveal different characteristics in the biological actions between WAT and BAT (Montrer BAAT Kits ELISA) in obese humans. Increased levels of IL6 (Montrer IL6 Kits ELISA), UCP1 and SIRT1 (Montrer SIRT1 Kits ELISA) in the BAT (Montrer BAAT Kits ELISA) were associated with metabolic parameters improvements.
UCP1 dietary activation can alleviate obesity. (Review)
The molecular features of UCP1 support a conventional mitochondrial carrier (Montrer UCP3 Kits ELISA)-like mechanism. (Review)
we find that rapamycin inhibits mTORC1 but not mTORC2 (Montrer CRTC2 Kits ELISA), leading to suppression of elevated lipolysis and restoration of thermogenic protein UCP1 levels, respectively
mTORC1 mediated many of the beneficial actions of FGF21 (Montrer FGF21 Kits ELISA) in vitro, including UCP1 and FGF21 (Montrer FGF21 Kits ELISA) induction, increased adiponectin secretion, and enhanced glucose uptake without any adverse effects on insulin (Montrer INS Kits ELISA) action.
Thus UCP1-dependent diet-induced thermogenesis limits obesity development during exposure to obesogenic diets but does not prevent obesity as such
This study demonstrated that elimination of the gene expressing uncoupling protein-1 (UCP1), the enzyme responsible for thermogenesis, prevented musculoskeletal hyperalgesia in response to either a swim or BRL37344.
Aortic UCP1 content was greater in females than males and its deletion improved ex vivo aortic vasomotor function in females only. Constitutive UCP1 content in BAT (Montrer BAAT Kits ELISA) was similar between females and males and loss of UCP1 did not abolish sex differences in insulin (Montrer INS Kits ELISA) sensitivity. Metabolic disruptions caused by UCP1 ablation did not appear to be contingent upon increased oxidative stress in mice under normal dietary conditions.
Gelidium elegans stimulates the expression of PRDM16 (Montrer PRDM16 Kits ELISA) and UCP-1 Protein in brown adipose tissue and suppresses hyperglycemia in high-fat diet mice.
through interaction with Zfp516 (Montrer ZNF516 Kits ELISA), LSD1 (Montrer KDM1A Kits ELISA) is recruited to UCP1 and other brown adipose tissue-enriched genes.
Together the data show that both UCP1 and UCP3 (Montrer UCP3 Kits ELISA) play essential and complementary roles in thermogenic responses in the mouse and suggest that UCP3 (Montrer UCP3 Kits ELISA)-dependent thermogenesis is an under-appreciated mode of thermogenic energy dissipation.
in vitro experiments show that Arrdc3-null adipocytes responded to beta-adrenergic receptor agonist with decreased Ucp1 levels
Despite the absence of UCP1 in the majority of epididymal beige (Montrer LYST Kits ELISA) adipocytes, these cells employ prominent creatine cycling as a UCP1-independent thermogenic mechanism.
The results of the present study provide an insight into the unexpected expression of Ucp1 in bovine skeletal muscle, which suggests the necessity for further studies on Ucp1-mediated energy expenditure in bovine skeletal muscle.
study suggests that uncoupling protein 1 affects milk yield, milk fat percentage and milk protein (Montrer CSN2 Kits ELISA) percentage
UCPs do have uncoupling properties when expressed in mitochondria but that uncoupling by UCP1 or UCP2 (Montrer UCP2 Kits ELISA) does not prevent acute substrate-driven endothelial cell superoxide as effluxed from mitochondria respiring in vitro.
These results suggest that CIDE-A (Montrer CIDEA Kits ELISA) and UCP1 are regulated by insulin (Montrer INS Kits ELISA) and/or fatty acids in mammary epithelial cells and lactating mammary glands, and thereby play an important role in lipid and energy metabolism.
Mitochondrial uncoupling proteins (UCP) are members of the family of mitochondrial anion carrier proteins (MACP). UCPs separate oxidative phosphorylation from ATP synthesis with energy dissipated as heat, also referred to as the mitochondrial proton leak. UCPs facilitate the transfer of anions from the inner to the outer mitochondrial membrane and the return transfer of protons from the outer to the inner mitochondrial membrane. They also reduce the mitochondrial membrane potential in mammalian cells. Tissue specificity occurs for the different UCPs and the exact methods of how UCPs transfer H+/OH- are not known. UCPs contain the three homologous protein domains of MACPs. This gene is expressed only in brown adipose tissue, a specialized tissue which functions to produce heat.
uncoupling protein 1 (mitochondrial, proton carrier)
, uncoupling protein 1
, mitochondrial brown fat uncoupling protein 1
, solute carrier family 25 member 7
, UCP 1
, uncoupling protein 1 UCP1
, uncoupling protein 1, mitochondrial
, uncoupling protein, mitochondrial
, mitochondrial, proton carrier
, Solute carrier family 25 member 7