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anti-Mouse (Murine) TP53BP1 Anticorps:
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Human Polyclonal TP53BP1 Primary Antibody pour ChIP, ICC - ABIN151771
Silverman, Takai, Buonomo, Eisenhaber, de Lange: Human Rif1, ortholog of a yeast telomeric protein, is regulated by ATM and 53BP1 and functions in the S-phase checkpoint. dans Genes & development 2004
Show all 70 Pubmed References
Human Polyclonal TP53BP1 Primary Antibody pour ICC, IF - ABIN152191
Murga, Jaco, Fan, Soria, Martinez-Pastor, Cuadrado, Yang, Blasco, Skoultchi, Fernandez-Capetillo: Global chromatin compaction limits the strength of the DNA damage response. dans The Journal of cell biology 2007
Show all 65 Pubmed References
Fish Polyclonal TP53BP1 Primary Antibody pour ChIP, FACS - ABIN151770
Riballo, Kühne, Rief, Doherty, Smith, Recio, Reis, Dahm, Fricke, Krempler, Parker, Jackson, Gennery, Jeggo, Löbrich: A pathway of double-strand break rejoining dependent upon ATM, Artemis, and proteins locating to gamma-H2AX foci. dans Molecular cell 2004
Show all 272 Pubmed References
Human Polyclonal TP53BP1 Primary Antibody pour ICC, FACS - ABIN151311
Kang, Lee, Hoan, Sohn, Chang, You: Protein phosphatase 5 regulates the function of 53BP1 after neocarzinostatin-induced DNA damage. dans The Journal of biological chemistry 2009
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Human Monoclonal TP53BP1 Primary Antibody pour BI, WB - ABIN968861
Iwabuchi, Bartel, Li, Marraccino, Fields: Two cellular proteins that bind to wild-type but not mutant p53. dans Proceedings of the National Academy of Sciences of the United States of America 1994
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Human Monoclonal TP53BP1 Primary Antibody pour BI, WB - ABIN968860
Iwabuchi, Li, Massa, Trask, Date, Fields: Stimulation of p53-mediated transcriptional activation by the p53-binding proteins, 53BP1 and 53BP2. dans The Journal of biological chemistry 1998
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Human Monoclonal TP53BP1 Primary Antibody pour FACS, IHC - ABIN1724821
Nakada, Yonamine, Matsuo: RNF8 regulates assembly of RAD51 at DNA double-strand breaks in the absence of BRCA1 and 53BP1. dans Cancer research 2012
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Human Monoclonal TP53BP1 Primary Antibody pour FACS, IHC - ABIN1724820
Mok, Henderson: The in vivo dynamic interplay of MDC1 and 53BP1 at DNA damage-induced nuclear foci. dans The international journal of biochemistry & cell biology 2012
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Human Polyclonal TP53BP1 Primary Antibody pour ICC, IF - ABIN4252095
Kondratova, Watanabe, Marotta, Cannon, Segall, Serre, Tanaka: Replication fork integrity and intra-S phase checkpoint suppress gene amplification. dans Nucleic acids research 2015
Fish Polyclonal TP53BP1 Primary Antibody pour FACS, ICC - ABIN4276945
Sykora, Misiak, Wang, Ghosh, Leandro, Liu, Tian, Baptiste, Cong, Brenerman, Fang, Becker, Hamilton, Chigurupati, Zhang, Egan, Croteau, Wilson, Mattson, Bohr: DNA polymerase β deficiency leads to neurodegeneration and exacerbates Alzheimer disease phenotypes. dans Nucleic acids research 2015
this study shows that 53BP1 is required for three-dimensional organization of the immunoglobulin heavy chain locus and provides a plausible explanation for the link with 53BP1 enforcement of deletional immunoglobulin class switch recombination
Genomic instability can be rescued by the deletion of Trp53bp1, which encodes the DNA damage response factor 53BP1, and mice expressing RING-less BRCA1 (Montrer BRCA1 Anticorps) do not show an increased susceptibility to tumors in the absence of 53BP1.
Unlike directly induced DSBs, secondary DSBs were not efficiently repaired, although Rad51 (Montrer RAD51 Anticorps) and 53BP1 were recruited to these sites. H2AX (Montrer H2AFX Anticorps) was dramatically stabilized in response to DSBs directly caused by gamma-rays, enabling gammaH2AX (Montrer H2AFX Anticorps) foci formation and DSB repair, whereas H2AX (Montrer H2AFX Anticorps) was barely stabilized in response to secondary DSBs, in which gammaH2AX (Montrer H2AFX Anticorps) foci were small and DSBs were not efficiently repaired
Study showed that mammalian cells use microtubules in the cytoplasm to promote the mobility of sites of DNA damage in the nucleus; molecular details of this process remain to be determined, the main players, including the MOB (Montrer SGMS1 Anticorps) domain of 53BP1, the linker of the nucleoskeleton, and cytoskeleton complex, kinesins, and microtubules are now known, allowing further study.
These experiments define a novel requirement for 53BP1 in the fusions of DNA-PKcs (Montrer PRKDC Anticorps)-deficient telomeres throughout the cell cycle.
Study concludes that only the 53BP1 status in DNA lesions, induced by UVA or gamma-rays, is affected by A-type lamin (Montrer LMNA Anticorps) deficiency, which was not observed for heterochromatin-related proteins HP1beta (Montrer CBX1 Anticorps) and BMI1 (Montrer BMI1 Anticorps).
Binding of 53BP1 to methyl K810 occurs on E2 promoter binding factor (Montrer E2F1 Anticorps) target genes and allows pRb (Montrer PGR Anticorps) activity to be effectively integrated with the DNA damage response.
study uncovers novel ATM (Montrer ATM Anticorps)-independent functions for 53BP1 in the suppression of oncogenic translocations and in radioprotection
Study concludes that 53BP1 promotes productive class switch recombination and suppresses mutagenic DNA repair through distinct phosphodependent interactions with RIF1 (Montrer RIF1 Anticorps) and PTIP (Montrer PAXIP1 Anticorps).
Thus, RIF1 and 53BP1 cooperate to block DSB resection to promote NHEJ in G1, which is antagonized by BRCA1 in S phase to ensure a switch of DSB repair mode to homologous recombination
Co-localization of gammaH2AX (Montrer H2AFX Anticorps) and 53BP1 indicates promotion of (in)effective nonhomologous end-joining repair mechanisms at sites of DSB. Moreover, gammaH2AX (Montrer H2AFX Anticorps)/53BP1 foci distribution presumably reveals a non-random spatial organization of the genome in MDS (Montrer PAFAH1B1 Anticorps) and AML (Montrer RUNX1 Anticorps).
Results provide evidence that 53BP1 is involved in breast cancer cells resistance for PARP (Montrer COL11A2 Anticorps) inhibitor; its depletion causes resistance in ATM (Montrer ATM Anticorps)-deficient tumor cells.
Ubiquitin ligases RNF168 (Montrer RNF168 Anticorps), RNF169 (Montrer RNF169 Anticorps), and RAD18 (Montrer RAD18 Anticorps) specifically bind histone H2A Lys13/15-ubiquitylated nucleosomes. 53BP1 chromatin recruitment may be activated by RNF168 (Montrer RNF168 Anticorps) and blocked by RNF169 (Montrer RNF169 Anticorps) and RAD18 (Montrer RAD18 Anticorps).
53BP1 embodies two distinct activities: it can act as a DNA repair factor on the chromatin that flanks double-strand DNA repairs, and it promotes optimal p53 (Montrer TP53 Anticorps) activity.
Ras-induced senescent cells are hindered in their ability to recruit BRCA1 and 53BP1 to DNA damage sites. Whereas BRCA1 is downregulated at transcripts levels, 53BP1 loss is caused by activation of cathepsin L (Montrer CTSL1 PLURAL_@161@)-mediated degradation of 53BP1 protein. we discovered a marked downregulation of vitamin D receptor (VDR) during OIS, and a role for the vitamin D/VDR (Montrer CYP27B1 PLURAL_@161@) axis regulating the levels of these DNA repair
53BP1-USP28 (Montrer USP28 Anticorps) cooperation is essential for normal p53 (Montrer TP53 Anticorps)-promoter element interactions and gene transactivation-associated events, yet dispensable for 53BP1-dependent DNA double-strand repair regulation.
TIP60 (Montrer KAT5 Anticorps) complex regulates bivalent chromatin recognition/modification by 53BP1 through direct H4K20me binding and H2AK15 acetylation.
findings identify TIRR as a new factor that influences double-strand break repair using a unique mechanism of masking the histone methyl-lysine binding function of 53BP1
Deficiency of 53BP1 inhibits the radiosensitivity of colorectal cancer.
interplay between 53BP1/NHEJ and BRCA1/HR is of great relevance for tumor treatment, as the 53BP1 status would be highly important for the treatment response of BRCA1-associated tumors.
May have a role in checkpoint signaling during mitosis. Enhances TP53-mediated transcriptional activation. Binds to sites of DNA damage. Plays a role in the response to DNA damage (By similarity).
tumor protein p53 binding protein 1
, tumor protein p53 binding protein, 1
, tumor suppressor p53-binding protein 1-like
, tumor protein p53 binding protein 1 (predicted), 5 prime
, tumor protein p53 binding protein 1 (predicted), 3 prime
, murine p53-binding protein
, p53-binding protein 1
, transformation related protein 53 binding-protein 1
, tumor suppressor p53-binding protein 1
, tumor protein 53-binding protein, 1
, tumor protein p53-binding protein, 1
, transformation related protein 53 binding protein 1