Aperçu des produits pour anti-LATS1 (LATS1) Anticorps

Full name:
anti-LATS, Large Tumor Suppressor, Homolog 1 (Drosophila) Anticorps (LATS1)
Chez www.anticorps-enligne.fr sont 78 LATS, Large Tumor Suppressor, Homolog 1 (Drosophila) (LATS1) Anticorps de 14 de différents fournisseurs disponibles. De plus, nous expédions et beaucoup plus de produits pour cette protéine. Un total de 89 LATS1 produits sont actuellement listés.
Synonymes:
AW208599, Lats, lats1, RGD1564085, si:dkey-181i3.5, WARTS, wts, wu:fc19a11, zgc:123219
afficher tous les anticorps Gène GeneID UniProt
LATS1 16798 Q8BYR2
LATS1 9113 O95835
LATS1 308265  

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anti-Mouse (Murine) LATS1 Anticorps:

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anti-LATS1 Anticorps mieux référencés

  1. Human Polyclonal LATS1 Primary Antibody pour IHC (p), WB - ABIN391033 : Iida, Hirota, Morisaki, Marumoto, Hara, Kuninaka, Honda, Kosai, Kawasuji, Pallas, Saya: Tumor suppressor WARTS ensures genomic integrity by regulating both mitotic progression and G1 tetraploidy checkpoint function. dans Oncogene 2004 (PubMed)
    Show all 6 references for 391033

  2. Cow (Bovine) Polyclonal LATS1 Primary Antibody pour WB - ABIN2787626 : Zhang, Smolen, Haber: Negative regulation of YAP by LATS1 underscores evolutionary conservation of the Drosophila Hippo pathway. dans Cancer research 2008 (PubMed)

  3. Human Polyclonal LATS1 Primary Antibody pour IP, WB - ABIN4891893 : Xiang, Gilkes, Hu, Takano, Luo, Lu, Bullen, Samanta, Liang, Semenza: Hypoxia-inducible factor 1 mediates TAZ expression and nuclear localization to induce the breast cancer stem cell phenotype. dans Oncotarget 2015 (PubMed)

  4. Human Polyclonal LATS1 Primary Antibody pour EIA, IHC (p) - ABIN359091 : Eiring, Neviani, Santhanam, Oaks, Chang, Notari, Willis, Gambacorti-Passerini, Volinia, Marcucci, Caligiuri, Leone, Perrotti: Identification of novel posttranscriptional targets of the BCR/ABL oncoprotein by ribonomics: requirement of E2F3 for BCR/ABL leukemogenesis. dans Blood 2008 (PubMed)

  5. Human Polyclonal LATS1 Primary Antibody pour IF (p), IHC (p) - ABIN872292 : Grijalva, Huizenga, Mueller, Rodriguez, Brazzo, Camargo, Sadri-Vakili, Vakili: Dynamic alterations in Hippo signaling pathway and YAP activation during liver regeneration. dans American journal of physiology. Gastrointestinal and liver physiology 2014 (PubMed)

Plus d’anticorps contre LATS1 partenaires d’interaction

Zebrafish LATS, Large Tumor Suppressor, Homolog 1 (Drosophila) (LATS1) interaction partners

  1. Thus AMOT (Montrer AMOT Anticorps) is a direct substrate of Lats1/2 mediating functions of the Hippo pathway in endothelial cell migration and angiogenesis.

  2. lats genes show distinctly different expression profiles during gastrulation. lats1 is almost ubiquitously expressed through development, and lats2 (Montrer LATS2 Anticorps) is more prominently expressed in the non-neural ectoderm region of zebrafish gastrula.

Mouse (Murine) LATS, Large Tumor Suppressor, Homolog 1 (Drosophila) (LATS1) interaction partners

  1. Study demonstrates that, in 3 different murine syngeneic tumor models (B16, SCC7, and 4T1), loss of the Hippo pathway kinases LATS1/2 (large tumor suppressor 1 and 2) in tumor cells inhibits tumor growth; data indicate a new paradigm for how tumor immunogenicity is regulated through the Hippo signaling pathway in tumor cells.

  2. Results showed that the Hippo pathway is active in ovarian follicles and that LATS1 is required to maintain the pool of germ cells and primordial follicles.

  3. The control of LATS activation by angiotensin II and subsequent YAP (Montrer YAP1 Anticorps) localization is important for podocyte homeostasis and survival.

  4. Willin (Montrer FRMD6 Anticorps) is predominantly expressed in fibroblasts and that Willin (Montrer FRMD6 Anticorps) expression activates the Hippo signaling cascade

  5. LATS1 tumor suppressor is a novel actin-binding protein and negative regulator of actin polymerization.

  6. KIBRA (Montrer WWC1 Anticorps) associates with and activates Lats (large tumor suppressor) 1 and 2 kinases by stimulating their phosphorylation on the hydrophobic motif

  7. Lats1 enhances the activity of FOXl2 (Montrer FOXL2 Anticorps) as a repressor of the StAr promoter. st

  8. Overexpression of YAP2 (Montrer YAP1 Anticorps) in cells promoted apoptosis, whereas the Mst2 (Montrer STK3 Anticorps)/Lats1-induced phosphorylation of YAP (Montrer YAP1 Anticorps) partially rescued the cells from apoptotic death.

  9. Genome-wide location arrays in cell lines of various cell types revealed that Lats1 was a transcriptional target of CUX1 (Montrer CUX1 Anticorps).

Human LATS, Large Tumor Suppressor, Homolog 1 (Drosophila) (LATS1) interaction partners

  1. TNFAIP8 (Montrer TNFAIP8 Anticorps) regulates Hippo (MST1 (Montrer MST1 Anticorps)/2) signaling through its interaction with LATS1.

  2. Lats1 SUMOylation at K751 suppresses its kinase activity and subsequently attenuates its tumor-suppressor functions in HepG2 cells.

  3. High LATS1 expression is associated with Colorectal Tumorigenesis and Metastasis.

  4. A group of miRNAs have been demonstrated to directly target components of the Hippo signaling pathway, such as YAP (Montrer YAP1 Anticorps), TAZ (Montrer TAZ Anticorps) and LATS1/2 in oncogenesis. (Review)

  5. findings reveal a non-canonical (that is, YAP (Montrer YAP1 Anticorps)/TAZ (Montrer TAZ Anticorps)-independent) effect of LATS in the regulation of human breast cell fate

  6. AGO2 (Montrer EIF2C2 Anticorps) immunoprecipitation revealed LATS1 as a novel proapoptotic target of miR (Montrer MLXIP Anticorps)-21 in T cells.

  7. LATS1 was downregulated in cervical cancer and may suppress cell growth and invasion through regulating the expression of cyclin E (Montrer CCNE1 Anticorps), p27 (Montrer PAK2 Anticorps), MMP9 (Montrer MMP9 Anticorps) and YAP (Montrer YAP1 Anticorps).

  8. PARD3 (Montrer PARD3 Anticorps) promotes interaction between PP1A (Montrer PPP1CA Anticorps) and LATS1 to induce LATS1 dephosphorylation and inactivation,leading to dephosphorylation and activation of TAZ (Montrer TAZ Anticorps)

  9. Loss of LATS1 expression is associated with breast neoplasms.

  10. Phosphorylation of CHO1 (Montrer KIF23 Anticorps) at S716 by Lats1 regulate its centrosomal localization, and that phosphorylated CHO1 (Montrer KIF23 Anticorps) interacts with and activates LIMK1 (Montrer LIMK1 Anticorps) during early mitosis.

LATS1 profil antigène

Antigen Summary

The protein encoded by this gene is a putative serine/threonine kinase that localizes to the mitotic apparatus and complexes with cell cycle controller CDC2 kinase in early mitosis. The protein is phosphorylated in a cell-cycle dependent manner, with late prophase phosphorylation remaining through metaphase. The N-terminal region of the protein binds CDC2 to form a complex showing reduced H1 histone kinase activity, indicating a role as a negative regulator of CDC2/cyclin A. In addition, the C-terminal kinase domain binds to its own N-terminal region, suggesting potential negative regulation through interference with complex formation via intramolecular binding. Biochemical and genetic data suggest a role as a tumor suppressor. This is supported by studies in knockout mice showing development of soft-tissue sarcomas, ovarian stromal cell tumors and a high sensitivity to carcinogenic treatments.

Alternative names and synonyms associated with LATS1

  • LATS, large tumor suppressor, homolog 1 (Drosophila) (LATS1) anticorps
  • LATS, large tumor suppressor, homolog 1 (Drosophila) (lats1) anticorps
  • LATS, large tumor suppressor, homolog 1 (TEgg117h14.1) anticorps
  • large tumor suppressor (Lats1) anticorps
  • large tumor suppressor kinase 1 (LATS1) anticorps
  • large tumor suppressor kinase 1 (Lats1) anticorps
  • AW208599 anticorps
  • Lats anticorps
  • lats1 anticorps
  • RGD1564085 anticorps
  • si:dkey-181i3.5 anticorps
  • WARTS anticorps
  • wts anticorps
  • wu:fc19a11 anticorps
  • zgc:123219 anticorps

Protein level used designations for LATS1

large tumor suppressor , serine/threonine-protein kinase LATS1 , LATS homolog 1 , LATS, large tumor suppressor, homolog 1 , LATS, large tumor suppressor, homolog 1 (Drosophila) , serine/threonine-protein kinase LATS1-like , WARTS protein kinase , large tumor suppressor homolog 1 , large tumor supressor, homolog 1 , LATS (large tumor suppressor, Drosophila) homolog 1 , h-warts , large tumor suppressor 1

GENE ID SPECIES
100060397 Equus caballus
553164 Danio rerio
748397 Pan troglodytes
100145677 Xenopus (Silurana) tropicalis
100410314 Callithrix jacchus
100455398 Pongo abelii
100467078 Ailuropoda melanoleuca
100539393 Meleagris gallopavo
100599863 Nomascus leucogenys
16798 Mus musculus
9113 Homo sapiens
308265 Rattus norvegicus
421627 Gallus gallus
100152165 Sus scrofa
535935 Bos taurus
476241 Canis lupus familiaris
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