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anti-Human EGR1 Anticorps:
anti-Mouse (Murine) EGR1 Anticorps:
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Cow (Bovine) Polyclonal EGR1 Primary Antibody pour IHC, WB - ABIN2779517
Yu, de Belle, Liang, Adamson: Coactivating factors p300 and CBP are transcriptionally crossregulated by Egr1 in prostate cells, leading to divergent responses. dans Molecular cell 2004
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Human Monoclonal EGR1 Primary Antibody pour ELISA, WB - ABIN969092
Chan, Lee, Ho, Wong, Lam, Tang, Chan, Abdullah, Wong, Lam: High-level expression of early growth response-1 and association of polymorphism with total IgE and atopy in allergic rhinitis adults. dans Clinica chimica acta; international journal of clinical chemistry 2009
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Human Monoclonal EGR1 Primary Antibody pour IF, IHC (p) - ABIN560707
Bupha-Intr, Holmes, Janssen: Induction of hypertrophy in vitro by mechanical loading in adult rabbit myocardium. dans American journal of physiology. Heart and circulatory physiology 2007
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Human Polyclonal EGR1 Primary Antibody pour ELISA, WB - ABIN560705
Hewetson, Chilton: Progesterone-dependent deoxyribonucleic acid looping between RUSH/SMARCA3 and Egr-1 mediates repression by c-Rel. dans Molecular endocrinology (Baltimore, Md.) 2008
Human Polyclonal EGR1 Primary Antibody pour FACS, IF - ABIN389442
Zhang, Chen, Wang, Guang, Han, Zhang, Tan, Gu: EGR1 decreases the malignancy of human non-small cell lung carcinoma by regulating KRT18 expression. dans Scientific reports 2014
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Chimpanzee Polyclonal EGR1 Primary Antibody pour IHC (p), ELISA - ABIN2473413
El-Asrar, Missotten, Geboes: Expression of high-mobility groups box-1/receptor for advanced glycation end products/osteopontin/early growth response-1 pathway in proliferative vitreoretinal epiretinal membranes. dans Molecular vision 2011
Egr-1 silencing through intracoronary delivery of a targeting DNAzyme at the time of reperfusion following acute myocardial ischemia decreases myocardial inflammation and apoptosis leading to improved cardiac function.
Intracoronary delivery of DNAzymes targeting human EGR-1 reduces infarct size following myocardial ischaemia reperfusion.
Data suggest that Egr-1 protein levels may be tightly regulated in an attempt to diminish neurotoxicity or to enhance plasticity in newborn animals.
Egr-1 upregulation is characteristic of the cardiovascular disease pathogenesis. (Review)
aberrant Egr1 expression, which can be suppressed by miR (Montrer MLXIP Anticorps)-181a-5p directly, plays a crucial role in the progression of renal Tubulointerstitial fibrosis in diabetic nephropathy.
Data suggest the EGR1-miR-30a-5p-NEUROD1 axis might serve as a promising biomarker for diagnosis and treatment monitoring for schizophrenic patients in acute psychotic state. EGR1 and miR-30a-5p were remarkably downregulated, whereas NEUROD1 was significantly upregulated in PBMNCs from patients in acute psychotic state.
The Egr-1 is essential for CSE (Montrer CSE Anticorps)-induced MUC5AC production in HBE (Montrer HBe1 Anticorps) cells likely through interaction with and modulation of AP-1 (Montrer FOSB Anticorps), and re-emphasize targeting Egr-1 as a novel therapeutic strategy for COPD (Montrer ARCN1 Anticorps).
Finally, the authors show that EGFR (Montrer EGFR Anticorps)-ERK1/2 (Montrer MAPK1/3 Anticorps) and beta1-integrin signaling are the main pathways used for bacteria-mediated EGR1 upregulation.
Early growth response (Egr)-1 is essential for fibrotic responses to Transforming growth factor (TGF)-beta (Montrer TGFB1 Anticorps). Egr-1 mediates TGF-beta1 (Montrer TGFB1 Anticorps)-induced COL1A1 (Montrer COL1A1 Anticorps) and COL1A2 (Montrer COL1A2 Anticorps) mRNA expression and acid-soluble collagen production in buccal mucosal fibroblasts (BMFs).The epigallocatechin-3-gallate (EGCG) can block TGF-beta1 (Montrer TGFB1 Anticorps)-induced collagen production by attenuating Egr-1 expression in BMFs.
Along with the reduction of ovarian cancer-2/disabled homolog 2 (DOC-2 (Montrer DAB2 Anticorps)/DAB2) interactive protein (DAB2IP (Montrer DAB2IP Anticorps)) expression, EGR-1 gene was upregulated in FI-treated cells. On the other hand, downregulation of EGR-1 gene expression sensitized radioresistant cells to IR accompanied by DAB2IP (Montrer DAB2IP Anticorps) overexpression and STAT3 (Montrer STAT3 Anticorps) inactivation. In addition, NF-kappaB (Montrer NFKB1 Anticorps) inhibitor, BAY11-7082 enhanced resistant cells' radiosensitivity and chemos...
ROS (Montrer ROS1 Anticorps) activation of the MAPK (ERK (Montrer MAPK1 Anticorps)-1 (Montrer MAPK3 Anticorps)/2)/Egr-1 pathway is a main player in the regulatory mechanism for cigarette smoke extract-induced PlGF (Montrer PGF Anticorps) production. Antioxidants could partly abolish these effects.
adipose tissue-derived mesenchymal stem cells (AT-MSCs) from diabetic patients may contribute to microvascular damage and delay wound healing through the overexpression of EGR-1.
KLF12 (Montrer KLF12 Anticorps) promotes tumor growth by directly activating early growth response protein 1 (EGR1). The levels of KLF12 (Montrer KLF12 Anticorps) and EGR1 correlate synergistically with a poor prognosis. These results indicate that KLF12 (Montrer KLF12 Anticorps) likely plays an important role in CRC (Montrer CALR Anticorps) and could serve as a potential prognostic marker and therapeutic target.
EGR1 can promote skeletal muscle satellite cell differentiation through positive regulation of MyoG (Montrer MYOG Anticorps) gene expression.
Chronic hypoxia induces Egr-1 via activation of ERK1/2 (Montrer MAPK1/3 Anticorps) and contributes to pulmonary vascular remodeling.
The authors conclude that Egr-1 protein expression is very sensitive to upregulation by hypoxia in pulmonary artery adventitial fibroblasts and that it plays an important role in the autonomous growth phenotype induced by hypoxia in these cells.
EGR-1's expression prior to ovulation and its stimulating effect on the expression of genes known to be involved in prostaglandin biosynthesis pathway, suggest its potential involvement in the regulation of preovulatory events in cattle.
miR (Montrer MLXIP Anticorps)-301b promotes the proliferation, migration, and aggressiveness of human bladder cancer cells by inhibiting the expression of EGR1
Low EGR1 expression is associated with cardiac ischemia and systolic dysfunction.
Herein, we report that silencing of Egr-1 in the hippocampus by shRNA reduces tau phosphorylation, lowers amyloid-beta (Abeta (Montrer APP Anticorps)) pathology, and improves cognition in the 3xTg-Alzheimer disease mouse model.
Egr-1 is a novel regulator of drebrin (Montrer DBN1 Anticorps) expression, which is linked to changes in dendritic spine density
In the present study, we have investigated the contribution of element C to Krox20 (Montrer EGR2 Anticorps) expression, as it was the only characterized initiator element with an activity in r3. Using a conditional knock-out mutation of element C, we show that, unexpectedly, this element is not necessary for Krox20 (Montrer EGR2 Anticorps) initial expression in r3.
HAS2 (Montrer HAS2 Anticorps)-produced hyaluronan is required for CD44V6 and TGFbetaRI co-localization and subsequent CD44V6/ERK1 (Montrer MAPK3 Anticorps)/EGR1 signaling. These results demonstrate a novel positive-feedback loop that links the myofibroblast phenotype to TGFbeta1 (Montrer TGFB1 Anticorps)-stimulated CD44V6/ERK (Montrer EPHB2 Anticorps)/EGR1 signaling.
Egr1 expression is sensitive to mechanical signals in tendon cells.
age-related up-regulation of EGR1 promotes granulosa cell apoptosis in follicle atresia during ovarian aging.
data indicate that Egr-1 promotes Abeta (Montrer APP Anticorps) synthesis via transcriptional activation of BACE-1 (Montrer BACE Anticorps) and suggest that Egr-1 plays role in activation of BACE-1 (Montrer BACE Anticorps) and acceleration of Abeta (Montrer APP Anticorps) synthesis in AD brain.
egr1 colocalizes with tyrosine hydroxylase (Montrer TH Anticorps) in the olfactory bulb throughout brain development.
successive induction of the transcription factors Runx3, Egr1 and Sox9b constitutes a regulatory cascade that controls expression of Follistatin A in pharyngeal endoderm, the latter modulating BMP signaling in developing cranial cartilage in zebrafish
The cDNA coding for zebrafish Egr1 was obtained and its expression pattern was examined during zebrafish embryogenesis using whole-mount in situ hybridization
Egr1 gene has important role in zebrafish embryonic oculogenesis. Lens and retina with egr1 gene deletion were primitive and lacked differentiation. Such arrested retinal and lenticular development in Egr1 morphants resulted in microphthalmos.
Gene therapy using in vivo transfection of an Egr-1 decoy ODN significantly inhibits proliferation of VSMC and intimal hyperplasia of vein grafts in a rabbit model.
Results show that EGR1 plays a key role in tendon formation, healing, and repair through BMP12 (Montrer GDF7 Anticorps)/Smad1 (Montrer SMAD1 Anticorps)/5/8 pathway.
Collectively, these results demonstrate that Egr-1 is expressed rapidly upon HSV-1 infection and that this novel induction could be due to the NFsmall ka, CyrillicB/CREB (Montrer CREB1 Anticorps)-mediated transactivation.
The protein encoded by this gene belongs to the EGR family of C2H2-type zinc-finger proteins. It is a nuclear protein and functions as a transcriptional regulator. The products of target genes it activates are required for differentitation and mitogenesis. Studies suggest this is a cancer suppresor gene.
early growth response protein 1(Egr-1, NGFI-A)
, early growth response protein 1 (egr-1)
, early growth response 1
, early growth response protein 1
, nerve growth factor-induced protein A
, transcription factor ETR103
, transcription factor Zif268
, zinc finger protein 225
, zinc finger protein Krox-24
, Krox-24 nuclear protein
, zinc finger protein ZENK
, zinc-finger transcriptional protein
, early growth response protein 1-A