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Human EGR1 Kit ELISA pour Sandwich ELISA - ABIN414979
Zhang, Zhu, Ba, Chen, Zhou, Cao, Wang, Ren, Wu: Gekko-sulfated glycopeptide inhibits tumor angiogenesis by targeting basic fibroblast growth factor. dans The Journal of biological chemistry 2012
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Mouse (Murine) EGR1 Kit ELISA pour Sandwich ELISA - ABIN415740
Moya-Pérez, Romo-Vaquero, Tomás-Barberán, Sanz, García-Conesa: Hepatic molecular responses to Bifidobacterium pseudocatenulatum CECT 7765 in a mouse model of diet-induced obesity. dans Nutrition, metabolism, and cardiovascular diseases : NMCD 2013
Human EGR1 Kit ELISA pour Sandwich ELISA - ABIN856951
Okuyama, Matsuda, Yamashita, Moriguchi-Goto, Sameshima, Iwakiri, Matsuura, Sato, Asada: Human Coronary Thrombus Formation Is Associated With Degree of Plaque Disruption and Expression of Tissue Factor and Hexokinase II. dans Circulation journal : official journal of the Japanese Circulation Society 2015
Egr-1 silencing through intracoronary delivery of a targeting DNAzyme at the time of reperfusion following acute myocardial ischemia decreases myocardial inflammation and apoptosis leading to improved cardiac function.
Intracoronary delivery of DNAzymes targeting human EGR-1 reduces infarct size following myocardial ischaemia reperfusion.
Data suggest that Egr-1 protein levels may be tightly regulated in an attempt to diminish neurotoxicity or to enhance plasticity in newborn animals.
The Egr-1 is essential for CSE-induced MUC5AC production in HBE (Montrer HBe1 Kits ELISA) cells likely through interaction with and modulation of AP-1 (Montrer FOSB Kits ELISA), and re-emphasize targeting Egr-1 as a novel therapeutic strategy for COPD (Montrer ARCN1 Kits ELISA).
Finally, the authors show that EGFR (Montrer EGFR Kits ELISA)-ERK1/2 (Montrer MAPK1/3 Kits ELISA) and beta1-integrin signaling are the main pathways used for bacteria-mediated EGR1 upregulation.
Early growth response (Egr)-1 is essential for fibrotic responses to Transforming growth factor (TGF)-beta (Montrer TGFB1 Kits ELISA). Egr-1 mediates TGF-beta1 (Montrer TGFB1 Kits ELISA)-induced COL1A1 (Montrer COL1A1 Kits ELISA) and COL1A2 (Montrer COL1A2 Kits ELISA) mRNA expression and acid-soluble collagen production in buccal mucosal fibroblasts (BMFs).The epigallocatechin-3-gallate (EGCG) can block TGF-beta1 (Montrer TGFB1 Kits ELISA)-induced collagen production by attenuating Egr-1 expression in BMFs.
Along with the reduction of ovarian cancer-2/disabled homolog 2 (DOC-2 (Montrer DAB2 Kits ELISA)/DAB2) interactive protein (DAB2IP (Montrer DAB2IP Kits ELISA)) expression, EGR-1 gene was upregulated in FI-treated cells. On the other hand, downregulation of EGR-1 gene expression sensitized radioresistant cells to IR accompanied by DAB2IP (Montrer DAB2IP Kits ELISA) overexpression and STAT3 (Montrer STAT3 Kits ELISA) inactivation. In addition, NF-kappaB (Montrer NFKB1 Kits ELISA) inhibitor, BAY11-7082 enhanced resistant cells' radiosensitivity and chemos...
ROS (Montrer ROS1 Kits ELISA) activation of the MAPK (ERK (Montrer MAPK1 Kits ELISA)-1 (Montrer MAPK3 Kits ELISA)/2)/Egr-1 pathway is a main player in the regulatory mechanism for cigarette smoke extract-induced PlGF (Montrer PGF Kits ELISA) production. Antioxidants could partly abolish these effects.
adipose tissue-derived mesenchymal stem cells (AT-MSCs) from diabetic patients may contribute to microvascular damage and delay wound healing through the overexpression of EGR-1.
KLF12 (Montrer KLF12 Kits ELISA) promotes tumor growth by directly activating early growth response protein 1 (EGR1). The levels of KLF12 (Montrer KLF12 Kits ELISA) and EGR1 correlate synergistically with a poor prognosis. These results indicate that KLF12 (Montrer KLF12 Kits ELISA) likely plays an important role in CRC (Montrer CALR Kits ELISA) and could serve as a potential prognostic marker and therapeutic target.
Shikonin induces apoptosis in some lung cancer cells via activation of FOXO3a (Montrer FOXO3 Kits ELISA)/EGR1/SIRT1 (Montrer SIRT1 Kits ELISA) signaling, and AKT (Montrer AKT1 Kits ELISA) and p300 (Montrer EP300 Kits ELISA) negatively regulate this process via Bim (Montrer BCL2L11 Kits ELISA) upregulation.
Inhibition of mTORC1-mediated 4EBP1 (Montrer EIF4EBP1 Kits ELISA) phosphorylation leads to decreased expression of c-MYC (Montrer MYC Kits ELISA) and subsequent upregulation of the proapoptotic BCL2 (Montrer BCL2 Kits ELISA) family member PUMA (Montrer BBC3 Kits ELISA), whereas inhibition of mTORC2 (Montrer CRTC2 Kits ELISA) results in nuclear factor-kappaB-mediated expression of the Early Growth Response 1 (EGR1) gene, which encodes a transcription factor that binds and transactivates the proapoptotic BCL2L11 (Montrer BCL2L11 Kits ELISA) locus encoding BIM (Montrer BCL2L11 Kits ELISA).
Conversely, siRNA-mediated Klotho (Montrer KL Kits ELISA) silencing up-regulated Egr-1, FN, and Col (Montrer HDAC1 Kits ELISA) I expression and the p-Smad3/Smad3 (Montrer SMAD3 Kits ELISA) ratio. Moreover, the effects of si-Klotho (Montrer KL Kits ELISA) on Egr-1 expression were abolished by the TGF-beta1 (Montrer TGFB1 Kits ELISA) inhibitor SB-431542. Klotho (Montrer KL Kits ELISA) overexpression can prevent mesangial ECM (Montrer MMRN1 Kits ELISA) production in high-glucose-treated human MCs (Montrer SMCP Kits ELISA), an effect that has been partially attributed to Egr-1 down-regulation facilitated by TGF-beta1 (Montrer TGFB1 Kits ELISA)/Smad3 (Montrer SMAD3 Kits ELISA) s...
EGR1 can promote skeletal muscle satellite cell differentiation through positive regulation of MyoG (Montrer MYOG Kits ELISA) gene expression.
Chronic hypoxia induces Egr-1 via activation of ERK1/2 (Montrer MAPK1/3 Kits ELISA) and contributes to pulmonary vascular remodeling.
The authors conclude that Egr-1 protein expression is very sensitive to upregulation by hypoxia in pulmonary artery adventitial fibroblasts and that it plays an important role in the autonomous growth phenotype induced by hypoxia in these cells.
EGR-1's expression prior to ovulation and its stimulating effect on the expression of genes known to be involved in prostaglandin biosynthesis pathway, suggest its potential involvement in the regulation of preovulatory events in cattle.
Low EGR1 expression is associated with cardiac ischemia and systolic dysfunction.
Herein, we report that silencing of Egr-1 in the hippocampus by shRNA reduces tau phosphorylation, lowers amyloid-beta (Abeta (Montrer APP Kits ELISA)) pathology, and improves cognition in the 3xTg-Alzheimer disease mouse model.
Egr-1 is a novel regulator of drebrin (Montrer DBN1 Kits ELISA) expression, which is linked to changes in dendritic spine density
In the present study, we have investigated the contribution of element C to Krox20 (Montrer EGR2 Kits ELISA) expression, as it was the only characterized initiator element with an activity in r3. Using a conditional knock-out mutation of element C, we show that, unexpectedly, this element is not necessary for Krox20 (Montrer EGR2 Kits ELISA) initial expression in r3.
HAS2 (Montrer HAS2 Kits ELISA)-produced hyaluronan is required for CD44V6 and TGFbetaRI co-localization and subsequent CD44V6/ERK1 (Montrer MAPK3 Kits ELISA)/EGR1 signaling. These results demonstrate a novel positive-feedback loop that links the myofibroblast phenotype to TGFbeta1 (Montrer TGFB1 Kits ELISA)-stimulated CD44V6/ERK (Montrer EPHB2 Kits ELISA)/EGR1 signaling.
Egr1 expression is sensitive to mechanical signals in tendon cells.
age-related up-regulation of EGR1 promotes granulosa cell apoptosis in follicle atresia during ovarian aging.
data indicate that Egr-1 promotes Abeta (Montrer APP Kits ELISA) synthesis via transcriptional activation of BACE-1 (Montrer BACE Kits ELISA) and suggest that Egr-1 plays role in activation of BACE-1 (Montrer BACE Kits ELISA) and acceleration of Abeta (Montrer APP Kits ELISA) synthesis in AD brain.
EGR1, an early growth response factor, is a critical transcription factor that regulates the hepatic clock circuit.
EGR1(-/-) mouse embryonic fibroblasts demonstrated lower susceptibility to Venezuelan equine encephalitis virus-induced cell death than isogenic wild-type fibroblasts, indicating that EGR1 modulates proapoptotic pathways following virus infection.
egr1 colocalizes with tyrosine hydroxylase (Montrer TH Kits ELISA) in the olfactory bulb throughout brain development.
successive induction of the transcription factors Runx3, Egr1 and Sox9b constitutes a regulatory cascade that controls expression of Follistatin A in pharyngeal endoderm, the latter modulating BMP signaling in developing cranial cartilage in zebrafish
The cDNA coding for zebrafish Egr1 was obtained and its expression pattern was examined during zebrafish embryogenesis using whole-mount in situ hybridization
Egr1 gene has important role in zebrafish embryonic oculogenesis. Lens and retina with egr1 gene deletion were primitive and lacked differentiation. Such arrested retinal and lenticular development in Egr1 morphants resulted in microphthalmos.
Gene therapy using in vivo transfection of an Egr-1 decoy ODN significantly inhibits proliferation of VSMC and intimal hyperplasia of vein grafts in a rabbit model.
Results show that EGR1 plays a key role in tendon formation, healing, and repair through BMP12 (Montrer GDF7 Kits ELISA)/Smad1 (Montrer SMAD1 Kits ELISA)/5/8 pathway.
Collectively, these results demonstrate that Egr-1 is expressed rapidly upon HSV-1 infection and that this novel induction could be due to the NFsmall ka, CyrillicB/CREB (Montrer CREB1 Kits ELISA)-mediated transactivation.
The protein encoded by this gene belongs to the EGR family of C2H2-type zinc-finger proteins. It is a nuclear protein and functions as a transcriptional regulator. The products of target genes it activates are required for differentitation and mitogenesis. Studies suggest this is a cancer suppresor gene.
early growth response protein 1(Egr-1, NGFI-A)
, early growth response protein 1 (egr-1)
, early growth response 1
, early growth response protein 1
, nerve growth factor-induced protein A
, transcription factor ETR103
, transcription factor Zif268
, zinc finger protein 225
, zinc finger protein Krox-24
, Krox-24 nuclear protein
, zinc finger protein ZENK
, zinc-finger transcriptional protein
, early growth response protein 1-A