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anti-Human IER3 Anticorps:
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Human Polyclonal IER3 Primary Antibody pour IHC, ELISA - ABIN1002470
Kondratyev, Chung, Jung: Identification and characterization of a radiation-inducible glycosylated human early-response gene. dans Cancer research 1996
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Human Polyclonal IER3 Primary Antibody pour FACS, IF - ABIN655735
Fellay, Ge, Shianna, Colombo, Ledergerber, Cirulli, Urban, Zhang, Gumbs, Smith, Castagna, Cozzi-Lepri, De Luca, Easterbrook, Günthard, Mallal, Mussini, Dalmau, Martinez-Picado, Miro, Obel, Wolinsky, Martinson, Detels, Margolick, Jacobson, Descombes, Anton: Common genetic variation and the control of HIV-1 in humans. dans PLoS genetics 2009
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Human Polyclonal IER3 Primary Antibody pour ELISA, ICC - ABIN4321045
Akilov, Wu, Ustyugova, Falo, Geskin: Resistance of Sézary cells to TNF-α-induced apoptosis is mediated in part by a loss of TNFR1 and a high level of the IER3 expression. dans Experimental dermatology 2012
we determined the molecular mechanism responsible for IER3 degradation, involving a ternary complex of IER3, MDM2 (Montrer MDM2 Anticorps) and FHL2 (Montrer FHL2 Anticorps), which may contribute to cervical tumor growth. Furthermore, we demonstrated that FHL2 (Montrer FHL2 Anticorps) serves as a scaffold for E3 ligase and its substrate during the ubiquitination reaction, a function that has not been previously reported for this protein
Analysis of consensus EGR (Montrer EGR1 Anticorps)-binding elements (EBEs) showed that the immediate early response 3 gene (IER3) is a novel transcriptional target gene of EGR2 (Montrer EGR2 Anticorps) as confirmed by the luciferase assay, electrophoretic mobility-shift assay (EMSA), chromatin immunoprecipitation (ChIP), and western blot analysis.
Study characterized IEX-1's expression and function in rheumatoid arthritis synovial fibroblasts and showed that IEX-1 is highly expressed in RA-SFs and negatively regulates RA-SF activation.
interleukin-1beta (IL-1beta (Montrer IL1B Anticorps))-induced IER3 expression is mediated by the ERK1/2 (Montrer MAPK1/3 Anticorps) target, transcription factor Elk-1 (Montrer ELK1 Anticorps).
findings suggest that IER3 is a putative tumor suppressor in the cervix, and the c-Ab1/p73beta/IER3 axis is a novel and crucial signaling pathway that confers etoposide chemosensitivity.
High expression of IER3 is associated with hepatocarcinoma.
In human samples removed from failed AVF, there was a significant increase in IEX-1 expression localized to the adventitia.
IEX-1 expression levels correlate with the severity of preeclampsia
Studied the binding effect of hcmv-miR (Montrer MLXIP Anticorps)-UL148D to the 3' untranslated region (3'UTR (Montrer UTS2R Anticorps)) of IEX-1.Results showed that only one binding site in the 3'UTR (Montrer UTS2R Anticorps) of IEX-1 was completely complementary to an 11nt sequence in the 5' terminus of hcmv-mir (Montrer MLXIP Anticorps)-UL148D.
the interference of IER3 with the PI3K (Montrer PIK3CA Anticorps)/Akt (Montrer AKT1 Anticorps)-Fyn (Montrer FYN Anticorps) pathway represents a novel mechanism of Nrf2 (Montrer GABPA Anticorps) regulation that may get lost in tumors and by which IER3 exerts its stress-adaptive and tumor-suppressive activity.
IER3 expression is blunted during heart failure development in a titin (Montrer TTN Anticorps)-deficient mouse model.
these results indicate that IER3 is a key player in expanding the pool of APC (Montrer APC Anticorps) while highlighting the role of distinct effectors found in an obese microenvironment in this process
Loss of IEX-1 results in reduced VNH accompanied with a decrease in proliferation, reduced fibroblast, myofibroblast, and Ly6C staining accompanied with increased apoptosis mediated through a reduction in Vegf-A (Montrer VEGFA Anticorps)/Mcp-1 (Montrer CPT1B Anticorps) axis and Mmp-9 (Montrer MMP9 Anticorps).
IER3 supports KRASG12D-associated oncogenesis in the pancreas by sustaining ERK1/2 (Montrer MAPK1/3 Anticorps) phosphorylation via phosphatase PP2A (Montrer PPP2R2B Anticorps) inhibition.
Stress-induced hematopoietic failure in the absence of immediate early (Montrer JUN Anticorps) response gene X-1 (IEX-1, IER3).
the interference of IER3 with the PI3K/Akt (Montrer AKT1 Anticorps)-Fyn (Montrer FYN Anticorps) pathway represents a novel mechanism of Nrf2 (Montrer NFE2L2 Anticorps) regulation that may get lost in tumors and by which IER3 exerts its stress-adaptive and tumor-suppressive activity.
IEX-1 has a role in activation of Erk (Montrer EPHB2 Anticorps) and NF-kB pathways, which affects thrombopoietin (Montrer THPO Anticorps)-promoted NHEJ DNA repair in hematopoietic stem cells
Data suggest a role for the immediate early (Montrer JUN Anticorps) response gene X-1 (IEX-1) in the control of colon epithelial homeostasis.
Our present investigation shows that null mutation of IEX-1 promotes differentiation of Th17 cells but compromises the survival of Th1 (Montrer HAND1 Anticorps) cells
IER3 plays a complex and to some extent contradictory role in cell cycle control and apoptosis. Effects of IER3 relate to an interference with certain signalling pathways
This gene functions in the protection of cells from Fas- or tumor necrosis factor type alpha-induced apoptosis. Partially degraded and unspliced transcripts are found after virus infection in vitro, but these transcripts are not found in vivo and do not generate a valid protein.
immediate early response 3
, radiation-inducible immediate-early gene IEX-1
, ATP-binding cassette, sub-family F (GCN20), member 1
, PACAP-responsive gene 1 protein
, anti-death protein
, differentiation-dependent gene 2 protein
, expressed in pancreatic carcinoma
, gly96, mouse, homolog of
, immediate early protein GLY96
, immediate early response 3 protein
, immediately early gene X-1
, protein DIF-2
, cAMP inducible gene 3