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Aperçu des produits pour anti-Pleckstrin Homology-Like Domain, Family A, Member 2 (PHLDA2) Anticorps

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anti-Pleckstrin Homology-Like Domain, Family A, Member 2 Anticorps (PHLDA2)
Chez www.anticorps-enligne.fr sont 83 Pleckstrin Homology-Like Domain, Family A, Member 2 (PHLDA2) Anticorps de 15 de différents fournisseurs disponibles. De plus, nous expédions Pleckstrin Homology-Like Domain, Family A, Member 2 Kits (21) et Pleckstrin Homology-Like Domain, Family A, Member 2 Protéines (21) et beaucoup plus de produits pour cette protéine. Un total de 130 Pleckstrin Homology-Like Domain, Family A, Member 2 produits sont actuellement listés.
Synonymes:
BRW1C, BWR1C, HLDA2, Ipl, phlda2, Tssc3, zgc:110459
afficher tous les anticorps Gène GeneID UniProt
PHLDA2 7262 Q53GA4
PHLDA2 22113 O08969
PHLDA2 293637  

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anti-Pleckstrin Homology-Like Domain, Family A, Member 2 Anticorps mieux référencés

  1. Human Polyclonal PHLDA2 Primary Antibody pour IF (p), IHC (p) - ABIN872459 : Jin, Qiao, Luan, Shang et al.: The expression of the imprinted gene pleckstrin homology-like domain family A member 2 in placental tissues of preeclampsia and its effects on the proliferation, migration and invasion of trophoblast ... dans Clinical and experimental pharmacology & physiology 2015 (PubMed)
    Show all 2 references for ABIN872459

  2. Human Polyclonal PHLDA2 Primary Antibody pour IHC, WB - ABIN2787605 : Dai, Huang, Li, Meng, Wang, Guo: TSSC3 overexpression associates with growth inhibition, apoptosis induction and enhances chemotherapeutic effects in human osteosarcoma. dans Carcinogenesis 2011 (PubMed)

  3. Human Monoclonal PHLDA2 Primary Antibody pour ELISA, WB - ABIN563272 : Suzuki, Shaw, Kaneko-Ishino, Ishino, Renfree: Characterisation of marsupial PHLDA2 reveals eutherian specific acquisition of imprinting. dans BMC evolutionary biology 2011 (PubMed)

  4. Human Polyclonal PHLDA2 Primary Antibody pour IHC (p), IHC - ABIN250091 : Qian, Frank, OKeefe, Dao, Zhao, Yuan, Wang, Keating, Walsh, Tycko: The IPL gene on chromosome 11p15.5 is imprinted in humans and mice and is similar to TDAG51, implicated in Fas expression and apoptosis. dans Human molecular genetics 1997 (PubMed)

Plus d’anticorps contre Pleckstrin Homology-Like Domain, Family A, Member 2 partenaires d’interaction

Human Pleckstrin Homology-Like Domain, Family A, Member 2 (PHLDA2) interaction partners

  1. PHLDA2 plays an important role in the occurrence and development of pregnancy complications by promoting trophoblast apoptosis and suppressing cell invasion.

  2. TSSC3 was a prognostic marker in osteosarcoma.

  3. TSSC3 downregulation promotes the Epithelial to mesenchymal transition (EMT (Montrer ITK Anticorps)) of osteosarcoma cells by regulating EMT (Montrer ITK Anticorps) markers via a signal transduction pathway that involves Snail (Montrer SNAI1 Anticorps), Wnt (Montrer WNT2 Anticorps)-beta-catenin (Montrer CTNNB1 Anticorps)/TCF (Montrer HNF4A Anticorps), and GSK-3beta (Montrer GSK3b Anticorps)

  4. Placental PHLDA2 expression was significantly 2.3 fold higher in reduced fetal movements pregnancies resulting in delivery of a growth restricted compared with a normal birth weight infant.

  5. PHLDA2 may promote the occurrence/development of preeclampsia by inhibiting proliferation/migration/invasion of trophoblasts.

  6. The gene expression pattern of CDKN1C (Montrer CDKN1C Anticorps), H19 (Montrer NCKAP1 Anticorps), IGF2, KCNQ1 (Montrer KCNQ1 Anticorps) and PHLDA2 genes was evaluated using RT-PCR.

  7. results suggest upregulated pleckstrin homology-like domain family A member 2 (PHLDA2) in placenta of monozygotic twins may be associated with the pathogenesis of singleton intrauterine growth restriction

  8. TSSC3 overexpression suppressed osteosarcoma cell growth and increased apoptosis through caspase-3 (Montrer CASP3 Anticorps) upregulation, suggesting that TSSC3 may play a pro-apoptosis role to maintain the normal balance of growth

  9. TSSC3 inhibits osteosarcoma tumorigenicity through reducing stemness and promoting apoptosis of tumor inducing cells

  10. A luciferase reporter assay was used to identify in the PHLDA2 promoter a 15 bp repeat sequence variant that significantly reduces PHLDA2-promoter efficiency. Maternal inheritance of the variant resulted in a significant increase in birth weight.

Mouse (Murine) Pleckstrin Homology-Like Domain, Family A, Member 2 (PHLDA2) interaction partners

  1. Phlda2 manipulates the placenta's demands for maternal resources, a process that must be tightly regulated by epigenetic marks to ensure optimal foetal growth.

  2. data support a direct role for elevated Phlda2 in limiting fetal growth but also suggest that growth restriction only manifests when there is limited placental reserve

  3. TSSC3 plays an important role in the differentiation from trophoblast stem cell to trophoblast progenitors and/or labyrinth trophoblasts through the TSSC3/PI3K/AKT (Montrer AKT1 Anticorps)/MASH2 (Montrer ASCL2 Anticorps) signaling pathway.

  4. Phlda2 gene is imprinted, with preferential expression from the maternal allele in placenta. It acts as a rheostat for placental growth, with overgrowth after gene deletion and growth retardation after loss of imprinting.

  5. A critical role for the imprinted Phlda2 gene in regulating glycogen (Montrer GYS1 Anticorps) storage in the eutherian placenta is identified.

  6. Embryonic expression of Ipl in mice

  7. Ipl and Tih1 (Montrer PHLDA3 Anticorps) are bona fide PH domain proteins, with broad specificity and moderate affinity for PIPs (Montrer GPRASP1 Anticorps).

Pig (Porcine) Pleckstrin Homology-Like Domain, Family A, Member 2 (PHLDA2) interaction partners

  1. In the present study, a 259 base pair-specific sequence for IPL gene of the domestic pig was obtained and a novel SNP, a T/C transition, was identified in IPL exon 1. Variable imprinting status of this gene was observed in different developmental stages.

  2. Quantitative allelic sequencing supports maternal expression of PHLDA2 in fetal liver and placental tissues using an interbreed swine model.

Cow (Bovine) Pleckstrin Homology-Like Domain, Family A, Member 2 (PHLDA2) interaction partners

  1. imprinting status of four cattle genes (Tssc4 (Montrer TSSC4 Anticorps),Nap1l4 (Montrer NAP1L4 Anticorps), Phlda2 and Osbpl5 (Montrer OSBPL5 Anticorps)) in seven types of tissues, were assessed in cattle.

  2. proper expression levels of the imprinted genes CDKN1C (Montrer CDKN1C Anticorps) and PHLDA2 are critical for embryo development

  3. Pleckstrin homology-like domain family A member 2 (PHLDA2) gene is expressed across a range of cattle fetal tissues and stages. It provides the first evidence that PHLDA2 is a monoallelically expressed imprinted gene in cattle fetal tissues and placenta.

Pleckstrin Homology-Like Domain, Family A, Member 2 (PHLDA2) profil antigène

Antigen Summary

This gene is located in a cluster of imprinted genes on chromosome 11p15.5, which is considered to be an important tumor suppressor gene region. Alterations in this region may be associated with the Beckwith-Wiedemann syndrome, Wilms tumor, rhabdomyosarcoma, adrenocortical carcinoma, and lung, ovarian, and breast cancer. This gene has been shown to be imprinted, with preferential expression from the maternal allele in placenta and liver.

Alternative names and synonyms associated with Pleckstrin Homology-Like Domain, Family A, Member 2 (PHLDA2)

  • pleckstrin homology-like domain, family A, member 2 (PHLDA2) anticorps
  • Pleckstrin homology-like domain family A member 2 (phla2) anticorps
  • pleckstrin homology-like domain, family A, member 2 (Phlda2) anticorps
  • pleckstrin homology-like domain, family A, member 2 (phlda2) anticorps
  • BRW1C anticorps
  • BWR1C anticorps
  • HLDA2 anticorps
  • Ipl anticorps
  • phlda2 anticorps
  • Tssc3 anticorps
  • zgc:110459 anticorps

Protein level used designations for PHLDA2

pleckstrin homology-like domain, family A, member 2 , pleckstrin homology-like domain family A member 2 , Imprinted in placenta and liver protein , beckwith-Wiedemann syndrome chromosomal region 1 candidate gene C protein , imprinted in placenta and liver protein , p17-BWR1C , p17-Beckwith-Wiedemann region 1 C , p17-Beckwith-Wiedemann region 1C , tumor suppressing subchromosomal transferable fragment cDNA 3 , tumor suppressing subtransferable candidate 3 , tumor-suppressing STF cDNA 3 protein , tumor-suppressing subchromosomal transferable fragment candidate gene 3 protein , tumor-supressing STF cDNA 3 , protein 50C15 , tumor-suppressing subchromosomal transferable fragment 3

GENE ID SPECIES
743049 Pan troglodytes
100196497 Salmo salar
7262 Homo sapiens
22113 Mus musculus
293637 Rattus norvegicus
100719774 Cavia porcellus
100379631 Sus scrofa
618810 Bos taurus
423088 Gallus gallus
100036975 Xenopus laevis
553622 Danio rerio
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