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anti-Mouse (Murine) APOE Anticorps:
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Human Monoclonal APOE Primary Antibody pour CyTOF, ELISA - ABIN258785
Wahrle, Jiang, Parsadanian, Hartman, Bales, Paul, Holtzman: Deletion of Abca1 increases Abeta deposition in the PDAPP transgenic mouse model of Alzheimer disease. dans The Journal of biological chemistry 2005
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Human Monoclonal APOE Primary Antibody pour IHC (fro), IHC (p) - ABIN536226
Zunarelli, Nicoll, Migaldi, Trentini: Apolipoprotein E polymorphism and breast carcinoma: correlation with cell proliferation indices and clinical outcome. dans Breast cancer research and treatment 2001
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Human Polyclonal APOE Primary Antibody pour IHC, WB - ABIN2774066
Ho, Niti, Yap, Kua, Ng: Metabolic syndrome and cognitive decline in chinese older adults: results from the singapore longitudinal ageing studies. dans The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry 2008
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Human Monoclonal APOE Primary Antibody pour FACS, IHC - ABIN968962
Karpouzis, Caridha, Tripsianis, Michailidis, Martinis, Veletza: Apolipoprotein E gene polymorphism in psoriasis. dans Archives of dermatological research 2009
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Human Polyclonal APOE Primary Antibody pour IHC (p), ELISA - ABIN1997537
Li, Jiang, Qu, Yao, Cai, Chen, Peng: Hepatocyte nuclear factor 4? and downstream secreted phospholipase A2 GXIIB regulate production of infectious hepatitis C virus. dans Journal of virology 2013
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Human Polyclonal APOE Primary Antibody pour IHC (p), IHC - ABIN250408
Dodart, Marr, Koistinaho, Gregersen, Malkani, Verma, Paul: Gene delivery of human apolipoprotein E alters brain Abeta burden in a mouse model of Alzheimer's disease. dans Proceedings of the National Academy of Sciences of the United States of America 2005
Mouse (Murine) Polyclonal APOE Primary Antibody pour ID, RID - ABIN151509
Terwel, Steffensen, Verghese, Kummer, Gustafsson, Holtzman, Heneka: Critical role of astroglial apolipoprotein E and liver X receptor-α expression for microglial Aβ phagocytosis. dans The Journal of neuroscience : the official journal of the Society for Neuroscience 2011
Human Monoclonal APOE Primary Antibody pour FACS, IHC - ABIN965577
Zintzaras, Kitsios, Triposkiadis, Lau, Raman: APOE gene polymorphisms and response to statin therapy. dans The pharmacogenomics journal 2009
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Mouse (Murine) Polyclonal APOE Primary Antibody pour IF (p), IHC (p) - ABIN725750
Chiu, Chan, Yang, Liu, Chiang: Supplementation of Chitosan Alleviates High-Fat Diet-Enhanced Lipogenesis in Rats via Adenosine Monophosphate (AMP)-Activated Protein Kinase Activation and Inhibition of Lipogenesis-Associated Genes. dans Journal of agricultural and food chemistry 2015
Human Polyclonal APOE Primary Antibody pour IHC (p), IP - ABIN152926
Atkinson, Blumenstein, Black, Wu, Kasabov, Taylor, Cooper, North: An altered pattern of circulating apolipoprotein E3 isoforms is implicated in preeclampsia. dans Journal of lipid research 2008
The combined data indicate that the K146N/R147W substitutions convert the full-length and the truncated apoE3[K146N/R147W] mutant into a dominant negative ligand that prevents receptor-mediated remnant clearance, exacerbates the dyslipidemia, and inhibits the biogenesis of HDL (Montrer HSD11B1 Anticorps).
The ApoE4 brains showed increased expression of interleukin receptor-associated kinase-1and downregulated by miR146) that correlated inversely with miR146a levels.
Rutaecarpine was identified to be a candidate that protected ApoE(-/-) mice from developing atherosclerosis through preferentially promoting activities of ABCA1 (Montrer ABCA1 Anticorps) and SR-BI (Montrer SCARB1 Anticorps) within RCT (Montrer FOXE3 Anticorps).
224 male F2 mice were generated from the two Apoe (-/-) strains to perform quantitative trait locus (QTL) analysis of atherosclerosis. F2 mice were fed 5 weeks of Western diet and analyzed for atherosclerotic lesions in the aortic root
Low dose dietary nitrate improves endothelial dysfunction and plaque stability in the ApoE-deficient mouse fed a high fat diet.
Ovariectomy and ApoE deficiency showed interaction potentializing the insulin (Montrer INS Anticorps) resistance, increasing triglycerides levels and altering angiotensin-converting enzyme (ACE (Montrer ACE Anticorps))-2 (Montrer ACE2 Anticorps) and Mas (Montrer MAS1 Anticorps) receptor gene expressions.
AMPK activation reduces the formation of atheromata-inducing macrophages in ApoE(-/-)-deficient mice by inhibiting expression of Ccr2, thereby preventing the Ccr2-mediated migration of Ly6C(hi) monocytes from the bone marrow.
Deletion of apolipoprotein E in astrocytes ameliorates the spatial learning and memory deficits in Alzheimer's disease by inhibiting TGF-beta (Montrer TGFB1 Anticorps)/Smad2 (Montrer SMAD2 Anticorps)/STAT3 (Montrer STAT3 Anticorps) signaling.
choroid plexus/CSF (Montrer CSF2 Anticorps) provides an additional source of apoE and the glymphatic fluid transporting system delivers it to brain via the periarterial space
Longxuetongluo capsule inhibits atherosclerosis progression in high-fat diet-induced ApoE(-/-) mice by improving endothelial dysfunction via MAPK (Montrer MAPK1 Anticorps)/IKK (Montrer CHUK Anticorps)/IkappaB/NF-kappaB (Montrer NFKB1 Anticorps) signaling pathway.
Levels of protein carbonyls were moderately higher in liver tissue of APOE4 vs. APOE3 mice. Other biomarkers of oxidative stress were similar between the two genotypes. Under basal conditions, the stress-response pathways investigated appeared largely unaffected by the APOE genotype
Mid-life socioeconomic status was positively associated with cognitive status among both Baby Boomers and pre-Boomers, even after adjusting for APOE polymorphism.
Influence of APOE varepsilon4 genotype on phospholipid profiles associated with mTBI and/or PTSD diagnostic categories.
Rather, we hypothesize that PA may protect APOE-epsilon4 allele carriers from selective neurodegeneration of individual fiber populations at locations of crossing fibers within projection and association WM fiber tracts.
ApoE epsilon2 as a risk factor in FTD (Montrer FTL Anticorps)-3 and epsilon4 plays a protective role in the disease.
The data indicate that the APOE rs405509 T homozygote modulates the effect of APOE epsilon4 on both cognitive performance and brain gray matter structure
ApoE2 and apoE4 increase the risk for heart disease; ApoE4 also increases the risk for neurodegenerative diseases. (Review)
in a population with low levels of cerebrovascular disease and a lower prevalence of SNAP than the general population, APOE and known genetic drivers of AD do not appear to contribute to the neurodegeneration observed in SNAP
Data conclude that the ER-stress mediated reduction in apoA-I (Montrer APOA1 Anticorps) transcription could be partly mediated via the inhibition of PPARalpha (Montrer PPARA Anticorps) mRNA expression and activity. In addition, BET inhibition increased apoA-I (Montrer APOA1 Anticorps) transcription, even if PPARalpha (Montrer PPARA Anticorps) production and activity were decreased. Both BET inhibition and PPARalpha (Montrer PPARA Anticorps) activation ameliorate the apoA-I (Montrer APOA1 Anticorps) lowering effect of ER-stress and are therefore interesting targets to elev...
Elevated cholesterol and APOE 4 genotype are independent risk factors for cognitive decline in ART-adherent HIV(+) men aged >50 years. Treatment of dyslipidemia may be an effective strategy to reduce cognitive decline in older HIV(+) individuals.
we report the efficient creation of an APOE knockout rabbit by using zinc finger nucleases. The knockout rabbits had drastically elevated cholesterol and moderately increased triglyceride levels, mimicking symptoms in human heart disease.
The molar ratio ApoE/ApoA-I (Montrer APOA1 Anticorps) is negatively correlated with the enzyme activity, and positively correlated with increases in the intima-media thickness of common carotid wall and cardiac dysfunction signs.
ApoE mimetic peptide reduces plasma lipid hydroperoxide content with a concomitant increase in HDL (Montrer HSD11B1 Anticorps) paraoxonase activity
The identification of disulphide-linked apoE dimers in cortical and hippocampal tissues represents a distinct structural difference between the apoE3 and apoE4 isoforms that may have functional consequences.
These data suggest that the -155T>A mutation in the promoter region of the porcine APOE gene is an important functional variant
Nonesterified fatty acids significantly inhibit the expression of ApoB100 (Montrer APOB Anticorps), ApoE, MTP (Montrer MTTP Anticorps), and LDLR (Montrer LDLR Anticorps), thereby decreasing the synthesis and assembly of VLDL and inducing TG accumulation in bovine hepatocytes.
Bovine apoE contents in triglyceride-rich lipoproteins are modulated by nutritional treatment and closely associated with triglyceride-rich lipoprotein metabolism
apoE-containing particles, which increased during the lactating stage, were not associated with HDL (Montrer HSD11B1 Anticorps) particles, and lipid-free forms were included in cow plasma
after calving the apolipoprotein B(100 (Montrer APOB Anticorps)) mRNA synthesis was lower, whereas microsomal triglyceride transfer protein (MTP (Montrer MTTP Anticorps)) and apolipoprotein E messenger RNA abundance were higher in the liver
The study found no coding variation within and between chimpanzee populations, suggesting that the maintenance of functionally diverse APOE polymorphisms is a unique feature of human evolution.
ApoE evolution and very likely the evolution of other apolipoproteins are influenced by feeding environment and diet of humans, chimpanzees and various other species.
In the hippocampus APOE protein levels were higher in good spatial performers than poor spatial performers animals
Allele frequencies of the ApoE gene found show that allele epsilon3 has one of the highest frequencies and epsilon4 allele one of the lowest compared to other population groups in the world
There was significantly more apoE immunoreactivity in the prefrontal cortex and hippocampus of aged animals compared to adult or middle-aged animals.
Chylomicron remnants and very low density lipoprotein (VLDL) remnants are rapidly removed from the circulation by receptor-mediated endocytosis in the liver. Apolipoprotein E, a main apoprotein of the chylomicron, binds to a specific receptor on liver cells and peripheral cells. ApoE is essential for the normal catabolism of triglyceride-rich lipoprotein constituents. The APOE gene is mapped to chromosome 19 in a cluster with APOC1 and APOC2. Defects in apolipoprotein E result in familial dysbetalipoproteinemia, or type III hyperlipoproteinemia (HLP III), in which increased plasma cholesterol and triglycerides are the consequence of impaired clearance of chylomicron and VLDL remnants.
, apolipoprotein E3