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anti-Mouse (Murine) APOE Anticorps:
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Human Monoclonal APOE Primary Antibody pour CyTOF, ELISA - ABIN258785
Wahrle, Jiang, Parsadanian, Hartman, Bales, Paul, Holtzman: Deletion of Abca1 increases Abeta deposition in the PDAPP transgenic mouse model of Alzheimer disease. dans The Journal of biological chemistry 2005
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Human Polyclonal APOE Primary Antibody pour IHC, WB - ABIN2774066
Ho, Niti, Yap, Kua, Ng: Metabolic syndrome and cognitive decline in chinese older adults: results from the singapore longitudinal ageing studies. dans The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry 2008
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Human Monoclonal APOE Primary Antibody pour IHC (fro), IHC (p) - ABIN536226
Zunarelli, Nicoll, Migaldi, Trentini: Apolipoprotein E polymorphism and breast carcinoma: correlation with cell proliferation indices and clinical outcome. dans Breast cancer research and treatment 2001
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Human Polyclonal APOE Primary Antibody pour IHC (p), ELISA - ABIN1997537
Li, Jiang, Qu, Yao, Cai, Chen, Peng: Hepatocyte nuclear factor 4? and downstream secreted phospholipase A2 GXIIB regulate production of infectious hepatitis C virus. dans Journal of virology 2013
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Human Monoclonal APOE Primary Antibody pour FACS, IHC - ABIN968962
Karpouzis, Caridha, Tripsianis, Michailidis, Martinis, Veletza: Apolipoprotein E gene polymorphism in psoriasis. dans Archives of dermatological research 2009
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Human Polyclonal APOE Primary Antibody pour IHC (p), WB - ABIN391849
Benga, Krieger, Dimitrova, Zeisel, Parnot, Lupberger, Hildt, Luo, McLauchlan, Baumert, Schuster: Apolipoprotein E interacts with hepatitis C virus nonstructural protein 5A and determines assembly of infectious particles. dans Hepatology (Baltimore, Md.) 2009
Human Polyclonal APOE Primary Antibody pour IHC (p), IHC - ABIN250408
Dodart, Marr, Koistinaho, Gregersen, Malkani, Verma, Paul: Gene delivery of human apolipoprotein E alters brain Abeta burden in a mouse model of Alzheimer's disease. dans Proceedings of the National Academy of Sciences of the United States of America 2005
Human Polyclonal APOE Primary Antibody pour IHC (p), IP - ABIN152926
Atkinson, Blumenstein, Black, Wu, Kasabov, Taylor, Cooper, North: An altered pattern of circulating apolipoprotein E3 isoforms is implicated in preeclampsia. dans Journal of lipid research 2008
Mouse (Murine) Polyclonal APOE Primary Antibody pour ID, RID - ABIN151509
Terwel, Steffensen, Verghese, Kummer, Gustafsson, Holtzman, Heneka: Critical role of astroglial apolipoprotein E and liver X receptor-α expression for microglial Aβ phagocytosis. dans The Journal of neuroscience : the official journal of the Society for Neuroscience 2011
Mouse (Murine) Polyclonal APOE Primary Antibody pour IF (p), IHC (p) - ABIN725750
Chiu, Chan, Yang, Liu, Chiang: Supplementation of Chitosan Alleviates High-Fat Diet-Enhanced Lipogenesis in Rats via Adenosine Monophosphate (AMP)-Activated Protein Kinase Activation and Inhibition of Lipogenesis-Associated Genes. dans Journal of agricultural and food chemistry 2015
apoE4 interacts wiith insulin receptor (Montrer INSR Anticorps) and impairs its trafficking by trapping it in the endosomes, leading to impaired insulin (Montrer INS Anticorps) signaling and insulin (Montrer INS Anticorps)-stimulated mitochondrial respiration and glycolysis.
UCP-2 (Montrer UCP2 Anticorps) prevents angiotensin-II-induced abdominal aortic aneurysm in apolipoprotein E-knockout mice via antioxidant and antiapoptotic activities.
treatment of APP/E4/Abca1+/- mice with liver X receptor (LXR) agonist T0 ameliorates APOE4-induced Alzheimer's disease (AD)-like pathology and therefore targeting the LXR-ABCA1-APOE regulatory axis could be effective as a potential therapeutic approach in AD patients, carriers of APOEepsilon4
Adiponectin (Montrer ADIPOQ Anticorps), TNF-alpha (Montrer TNF Anticorps), and LOX-1 (Montrer OLR1 Anticorps) exert complex regulatory effects on the coronary microvascular endothelial function in atherosclerotic ApoE knockout mice.
Apoe-deficient mice and human apoE isoform knockin mice, as well as hypomorphic Apoe mice, have significantly contributed to our understanding of the role of apoE in lipoprotein metabolism. [review]
beta-Sarcoglycan (Montrer SGCB Anticorps) deficiency reduces atherosclerotic plaque formation in ApoE-knockout mouse model.
we found that the lack of microbiota caused a significant reduction in atherosclerotic lesion formation compared with Conv ApoE(-/-) mice, which might be associated with the attenuation of lipopolysaccharide-mediated inflammatory responses. Our findings indicated that the gut (Montrer GUSB Anticorps) microbiota affected both hypercholesterolemia and atherogenesis in mice
this reduction in lesion formation was associated with reduced numbers of lesional SMCs but not macrophages within the transplanted Cx3cr-/- Apoe-/- aortic segment. No differences in frequencies of proliferating and apoptotic cells could be observed. These results indicate that CX3CR1 (Montrer CX3CR1 Anticorps) on resident vessel wall cells plays a key role in atherosclerotic plaque formation in transplanted aortic grafts
Specific inhibition of the NLRP3 (Montrer NLRP3 Anticorps) inflammasome using MCC950 can be a promising therapeutic approach to inhibit atherosclerotic lesion development in ApoE deficient mice.
catK (Montrer CTSK Anticorps) deficiency almost completely blunted the increased vascular remodeling response of apoE-/- mice to flow cessation, possibly by correcting hyperlipidemia-associated pro-inflammatory effects on the peripheral immune response
Possession of an Apolipoprotein E (APOE) e4 allele is an established risk factor for Alzheimer's disease.
Association between an Alzheimer's Disease-Related Index and APOE epsilon4 Gene Dose
ApoE levels positively associate with incident CVD risk with apoE-associated risk likely residing in apoB (Montrer APOB Anticorps)-containing lipoproteins
APOE protein plays a significant role in Oral squamous cell carcinoma tumor invasion
Results showed that the APOE varepsilon4 genotype impaired neither explicit memory nor memory-based orienting of spatial attention. Interestingly, however, we found that the possession of the varepsilon4 allele broke the relationship between declarative long-term memory and memory-guided orienting of visuo-spatial attention, suggesting an earlier modulation exerted by pure genetic characteristics on cognition.
Report presents the largest population-based study on APOE allele distribution and its association with Alzheimer's disease carried out in China. The results showed the general distribution of ApoE alleles and genotypes similar to those observed in the non-Chinese populations in Western countries. The results suggest that ApoEepsilon4 allele is a risk factor of Alzheimer's disease for Chinese population.
The findings of this study suggested that inheritance of APOE-epsilon4 causes life long changes to the brain that may be related to the late risk of Alzheimer's Disease.
ApoE associated with Familial Hypercholesterolemia and Polygenic Hypercholesterolemia in patients with Acute Coronary Syndrome , age =65 years, and LDL-C levels >/=160 mg/dl.
Study found enrichment of epistasis in gonadotropin-releasing hormone signaling with risk single-nucleotide polymorphisms in APOE and MS4A6A (Montrer MS4A6A Anticorps). Results suggest that in addition to APOE, MS4A6A (Montrer MS4A6A Anticorps) polymorphisms should be considered in hormone trials targeting gonadotropins.
Among white women, three single nucleotide polymorphisms (SNPs) (rs2075650 [TOMM40 (Montrer TOMM40 Anticorps)], rs4420638 [APOC1 (Montrer APOC1 Anticorps)], and rs429358 [APOE]) were significantly associated with survival to 90 years after correction for multiple testing (p < .001); rs4420638 and rs429358 were also significantly associated with healthy aging (p = .02). In African American women, no SNP was associated with longevity. In Hispanic women, 7 SNPs in linkage dise
we report the efficient creation of an APOE knockout rabbit by using zinc finger nucleases. The knockout rabbits had drastically elevated cholesterol and moderately increased triglyceride levels, mimicking symptoms in human heart disease.
The molar ratio ApoE/ApoA-I (Montrer APOA1 Anticorps) is negatively correlated with the enzyme activity, and positively correlated with increases in the intima-media thickness of common carotid wall and cardiac dysfunction signs.
ApoE mimetic peptide reduces plasma lipid hydroperoxide content with a concomitant increase in HDL (Montrer HSD11B1 Anticorps) paraoxonase activity
The identification of disulphide-linked apoE dimers in cortical and hippocampal tissues represents a distinct structural difference between the apoE3 and apoE4 isoforms that may have functional consequences.
These data suggest that the -155T>A mutation in the promoter region of the porcine APOE gene is an important functional variant
Nonesterified fatty acids significantly inhibit the expression of ApoB100 (Montrer APOB Anticorps), ApoE, MTP (Montrer MTTP Anticorps), and LDLR (Montrer LDLR Anticorps), thereby decreasing the synthesis and assembly of VLDL and inducing TG accumulation in bovine hepatocytes.
Bovine apoE contents in triglyceride-rich lipoproteins are modulated by nutritional treatment and closely associated with triglyceride-rich lipoprotein metabolism
apoE-containing particles, which increased during the lactating stage, were not associated with HDL (Montrer HSD11B1 Anticorps) particles, and lipid-free forms were included in cow plasma
after calving the apolipoprotein B(100 (Montrer APOB Anticorps)) mRNA synthesis was lower, whereas microsomal triglyceride transfer protein (MTP (Montrer MTTP Anticorps)) and apolipoprotein E messenger RNA abundance were higher in the liver
The study found no coding variation within and between chimpanzee populations, suggesting that the maintenance of functionally diverse APOE polymorphisms is a unique feature of human evolution.
ApoE evolution and very likely the evolution of other apolipoproteins are influenced by feeding environment and diet of humans, chimpanzees and various other species.
In the hippocampus APOE protein levels were higher in good spatial performers than poor spatial performers animals
Allele frequencies of the ApoE gene found show that allele epsilon3 has one of the highest frequencies and epsilon4 allele one of the lowest compared to other population groups in the world
There was significantly more apoE immunoreactivity in the prefrontal cortex and hippocampus of aged animals compared to adult or middle-aged animals.
Chylomicron remnants and very low density lipoprotein (VLDL) remnants are rapidly removed from the circulation by receptor-mediated endocytosis in the liver. Apolipoprotein E, a main apoprotein of the chylomicron, binds to a specific receptor on liver cells and peripheral cells. ApoE is essential for the normal catabolism of triglyceride-rich lipoprotein constituents. The APOE gene is mapped to chromosome 19 in a cluster with APOC1 and APOC2. Defects in apolipoprotein E result in familial dysbetalipoproteinemia, or type III hyperlipoproteinemia (HLP III), in which increased plasma cholesterol and triglycerides are the consequence of impaired clearance of chylomicron and VLDL remnants.
, apolipoprotein E3