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These findings suggest that CADM1 expression is a novel prognostic factor for peripheral T cell lymphoma, not otherwise specified
miR (Montrer MLXIP Kits ELISA)-21 enhances chemo-resistance in tongue cancer cells via directly targeting CADM1, and an inverse correlation between miR (Montrer MLXIP Kits ELISA)-21 and CADM1 expression in vivo. MiR (Montrer MLXIP Kits ELISA)-21 overexpression is attributed to MYCN (Montrer MYCN Kits ELISA)-mediated transcriptional regulation, which is also predictive for a worse prognosis in tongue cancer
We conclude that CADM1 was not associated with cell-cell interaction between lymphoma cells and macrophages, although CADM1 may be a useful marker of ATLL for diagnostic procedures.
miR (Montrer MLXIP Kits ELISA)-21 overexpression promotes cardiac fibrosis via STAT3 (Montrer STAT3 Kits ELISA) signaling pathway by decrease CADM1 expression, indicating miR (Montrer MLXIP Kits ELISA)-21 as an important signaling molecule for cardiac fibrotic remodeling and atrial fibrillation.
Pathway analysis of the genes associated with the 46 CpG sites revealed an enrichment of immune system process genes, including LYST (Montrer LYST Kits ELISA) (cg16962115, FDR = 1.24E-04), CADM1 (cg21933078, FDR = 1.22E-02) and NFATC1 (Montrer NFATC1 Kits ELISA) (cg06784563, FDR = 1.46E-02)
CADM1 mRNA expression was highly upregulated in normal tissues compared to esophageal squamous cell carcinoma tissues, indicating that the loss of CADM1 expression influenced the pathogenesis, invasion, and metastasis of ESCC.
Eight and five of the nine samples were negative for cell adhesion molecule 1 and Osterix (Montrer SP7 Kits ELISA) respectively. The other markers showed no statistical significance(CD151 (Montrer CD151 Kits ELISA),ALP (Montrer ALP Kits ELISA)). osteoblastic differentiation can occur in carcinoma cells and that cell adhesion molecule 1 could be a useful marker for identifying this phenomenon in carcinoma tissues
Our results suggest that, as in the CNS, CADM1 interactions drive exocytic site assembly and promote actin network formation. These results support the broader hypothesis that the effects of cell-cell contact on beta-cell maturation and function are mediated by the same extracellular protein interactions that drive the formation of the presynaptic exocytic machinery. These interactions may be therapeutic targets for re...
High expression of CADM1 on most HTLV-1-infected cells in the face of enhanced cytotoxic T lymphocyte counterselection implies that CADM1 confers a strong benefit on the virus.
Decreased expression of TSLC1 is associated with the differentiation in ovarian epithelial cancer. TSLC1 might be used as a molecular marker of severity in early stage ovarian cancer, and to help differentiating benign and malignant ovarian tumors.
NF-kB mediated upregulation of CADM1 was identified as a mechanism of TNFalpha (Montrer TNF Kits ELISA) induced migration.
The results of this study demonstrate that the synapse-organizing adhesion molecule (Montrer NCAM1 Kits ELISA) SynCAM 1 has pronounced effects on neuronal connectivity in the hippocampal CA3 (Montrer CA3 Kits ELISA) area.
Cadm1 is a direct target of NFATc1 (Montrer NFATC1 Kits ELISA), which is induced by RANKL (Montrer TNFSF11 Kits ELISA) through epigenetic modification, and regulates osteoclastic bone resorption in a negative feedback manner.
Data show that cell adhesion molecule 1 (SynCAM 1) generally prolongs the lifetime of spines.
This experiments show that the survival rate of adult-generated neurons is increased by overexpressing SynCAM 1
Our study reveals a novel mechanism of chronic NF-kappaB (Montrer NFKB1 Kits ELISA) activation by CADM1 in HTLV-1 infected cells
Study demonstrates that polysialic acid-SynCAM 1 defines a subpopulation of NG2 (Montrer Vcan Kits ELISA) cells and identifies the presence of polysialic acid-NRP2 (Montrer NRP2 Kits ELISA) in microglia
CADM1 appeared to sustain gap junctional intercellular communication among alpha-cells via homophilic binding and, based on this action, CADM1 appears to prevent excessive secretion of glucagon (Montrer GCG Kits ELISA) from alpha-cells.
This study demonistrated that SynCAM 1 in the synaptic organization of the rod visual pathway and provide evidence for novel roles of synaptic adhesion in the structural and functional integrity of ribbon synapses.
Necl-2 co-localizes with ErbB4 (Montrer ERBB4 Kits ELISA) in hippocampus and and regulates ErbB4 (Montrer ERBB4 Kits ELISA) signaling in cultured neurons.
Mediates homophilic cell-cell adhesion in a Ca(2+)- independent manner. Also mediates heterophilic cell-cell adhesion with CADM3 and PVRL3 in a Ca(2+)-independent manner. Acts as a tumor suppressor in non-small-cell lung cancer (NSCLC) cells. Interaction with CRTAM promotes natural killer (NK) cell cytotoxicity and interferon-gamma (IFN-gamma) secretion by CD8+ cells in vitro as well as NK cell-mediated rejection of tumors expressing CADM3 in vivo. May contribute to the less invasive phenotypes of lepidic growth tumor cells. In mast cells, may mediate attachment to and promote communication with nerves. CADM1, together with MITF, is essential for development and survival of mast cells in vivo. May act as a synaptic cell adhesion molecule that drives synapse assembly. May be involved in neuronal migration, axon growth, pathfinding, and fasciculation on the axons of differentiating neurons. May play diverse roles in the spermatogenesis including in the adhesion of spermatocytes and spermatids to Sertoli cells and for their normal differentiation into mature spermatozoa.
, TSLC1/Nectin-like 2/IGSF4
, immunoglobulin superfamily member 4
, immunoglobulin superfamily, member 4
, immunoglobulin superfamily, member 4D variant 1
, immunoglobulin superfamily, member 4D variant 2
, nectin-like 2
, nectin-like protein 2
, spermatogenic immunoglobulin superfamily
, synaptic cell adhesion molecule
, truncated CADM1 protein
, tumor suppressor in lung cancer 1
, cell adhesion molecule 1
, cell adhesion molecule 1 transcript variant 8abc
, immunoglobulin superfamily member 4A
, immunosuperfamily protein Bl2
, immunoglobulin superfamily, member 4A
, secretory isoform of TSLC1
, tumor suppressor in lung cell-1