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CLF-1 (Montrer CRLF1 Kits ELISA), based on its binding site for CLC (Montrer CLC Kits ELISA) and on two additional and independent sites for CNTFRalpha (Montrer CNTFR Kits ELISA) and sorLA (Montrer SORL1 Kits ELISA), is a key player in CLC (Montrer CLC Kits ELISA) and CNTFRalpha (Montrer CNTFR Kits ELISA) signaling and turnover.
Cardiotrophin-like cytokine factor 1 (CLCF1) and neuropoietin (NP) signalling and their roles in development, adulthood, cancer and degenerative disorders.
albuminuria in focal segmental glomerulosclerosis is related to qualitative or quantitative changes in the CLCF1-CRLF1 (Montrer CRLF1 Kits ELISA) complex.
activation of the Jak (Montrer JAK3 Kits ELISA)-STAT (Montrer STAT1 Kits ELISA) cascade is essential for corticotroph NNT-1/BSF-3 signaling.
Structural and docking interaction studies showed that the R197L substitution destabilized the contact site between CLC (Montrer CLC Kits ELISA) and CNTFRalpha (Montrer CNTFR Kits ELISA).
Ciliary neurotrophic factor (Montrer CNTF Kits ELISA), cardiotrophin-like cytokine, and neuropoietin share a conserved binding site on the ciliary neurotrophic factor receptor alpha (Montrer CNTFR Kits ELISA) chain (Montrer FCGRT Kits ELISA)
CLC (Montrer CLC Kits ELISA) plays a role in astrocyte differentiation via STAT3 (Montrer STAT3 Kits ELISA) activation within the developing brain
neurotrophin-1/B-cell stimulating factor 3(NNT-1/BSF-3) is expressed in pituitary folliculostellate TtT/GF cells and induced by PKC (Montrer PKC Kits ELISA)-, PKA-, and ERK1/2 (Montrer MAPK1/3 Kits ELISA)-dependent mechanisms
IL-6 (Montrer IL6 Kits ELISA) (gp130 (Montrer LRPPRC Kits ELISA)) family cytokine members include CLC/NNT1/BSF3 and IL-27 (Montrer IL27 Kits ELISA) [review]
In this study, Clc (Montrer CLC Kits ELISA) knockout mice had decreased facial motility, did not suckle, died within 24 hours, and had 32% and 29% fewer motor neurons in the facial nucleus and lumbar ventral horn, respectively.
This gene is a member of the glycoprotein (gp)130 cytokine family and encodes cardiotrophin-like cytokine factor 1 (CLCF1). CLCF1 forms a heterodimer complex with cytokine receptor-like factor 1 (CRLF1). This dimer competes with ciliary neurotrophic factor (CNTF) for binding to the ciliary neurotrophic factor receptor (CNTFR) complex, and activates the Jak-STAT signaling cascade. CLCF1 can be actively secreted from cells by forming a complex with soluble type I CRLF1 or soluble CNTFR. CLCF1 is a potent neurotrophic factor, B-cell stimulatory agent and neuroendocrine modulator of pituitary corticotroph function. Defects in CLCF1 cause cold-induced sweating syndrome 2 (CISS2). This syndrome is characterized by a profuse sweating after exposure to cold as well as congenital physical abnormalities of the head and spine. Alternative splicing results in multiple transcript variants encoding distinct isoforms.
cardiotrophin-like cytokine factor 1
, B-cell stimulating factor 3
, B-cell stimulatory factor 3
, B-cell-stimulating factor 3
, CRLF1 associated cytokine-like factor 1
, neurotrophin-1/B-cell stimulating factor-3
, novel neurotrophin-1
, b cell-stimulating factor 3
, cardiotrophin-like cytokine