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Aperçu des produits pour anti-SH2 Domain Containing 1A (SH2D1A) Anticorps

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anti-SH2 Domain Containing 1A Anticorps (SH2D1A)
Chez sont 121 SH2 Domain Containing 1A (SH2D1A) Anticorps de 19 de différents fournisseurs disponibles. De plus, nous expédions SH2 Domain Containing 1A Protéines (20) et SH2 Domain Containing 1A Kits (1) et beaucoup plus de produits pour cette protéine. Un total de 150 SH2 Domain Containing 1A produits sont actuellement listés.

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anti-SH2 Domain Containing 1A Anticorps mieux référencés

  1. Human Monoclonal SH2D1A Primary Antibody pour ELISA, WB - ABIN561703 : Ma, Suryani, Avery, Chan, Nanan, Santner-Nanan, Deenick, Tangye: Early commitment of naïve human CD4(+) T cells to the T follicular helper (T(FH)) cell lineage is induced by IL-12. dans Immunology and cell biology 2009 (PubMed)
    Show all 5 references for ABIN561703

  2. Human Polyclonal SH2D1A Primary Antibody pour WB - ABIN1881802 : Snow, Marsh, Krummey, Roehrs, Young, Zhang, van Hoff, Dhar, Nichols, Filipovich, Su, Bleesing, Lenardo: Restimulation-induced apoptosis of T cells is impaired in patients with X-linked lymphoproliferative disease caused by SAP deficiency. dans The Journal of clinical investigation 2009 (PubMed)
    Show all 5 references for ABIN1881802

  3. Human Polyclonal SH2D1A Primary Antibody pour ELISA, WB - ABIN251451 : Romero, Benítez, March, Vilella, Miralpeix, Engel: Differential expression of SAP and EAT-2-binding leukocyte cell-surface molecules CD84, CD150 (SLAM), CD229 (Ly9) and CD244 (2B4). dans Tissue antigens 2004 (PubMed)

  4. Human Polyclonal SH2D1A Primary Antibody pour WB - ABIN374582 : Mikhalap, Shlapatska, Yurchenko, Yurchenko, Berdova, Nichols, Clark, Sidorenko: The adaptor protein SH2D1A regulates signaling through CD150 (SLAM) in B cells. dans Blood 2004 (PubMed)

  5. Human Polyclonal SH2D1A Primary Antibody pour IP, WB - ABIN265020 : Sayos, Wu, Morra, Wang, Zhang, Allen, van Schaik, Notarangelo, Geha, Roncarolo, Oettgen, De Vries, Aversa, Terhorst: The X-linked lymphoproliferative-disease gene product SAP regulates signals induced through the co-receptor SLAM. dans Nature 1998 (PubMed)

Plus d’anticorps contre SH2 Domain Containing 1A partenaires d’interaction

Human SH2 Domain Containing 1A (SH2D1A) interaction partners

  1. High LAT1 (Montrer LAT Anticorps) expression correlated with significantly shorter prostate specific antigen (Montrer KLK3 Anticorps) recurrence-free survival in patients receiving androgen deprivation therapy

  2. We describe here a novel c.137+5G > A intronic mutation in the SH2D1A gene of the signaling lymphocyte activation molecule (SLAM (Montrer SLAMF1 Anticorps))-associated protein (SAP) in association with Epstein-Barr virus (EBV)-induced fatal infectious mononucleosis (FIM (Montrer ZMYM2 Anticorps)) in an 8-year-old male patient and his 3-year-old step brother. The mother and the maternal grandmother of the boys are healthy and heterozygous for this sequence variant.

  3. In addition to their role in NK cell activation by hematopoietic cells, the SLAM-SAP-SHP1 pathways influence responsiveness toward nonhematopoietic targets by a process akin to NK cell 'education'.

  4. The mutation c.131G>A in this patient was found in combination with a second SH2D1A mutation

  5. Study of SAP (Montrer APCS Anticorps) expression is specific but may have insufficient sensitivity for screening XLP1 as a single tool; however, combination with 2B4 (Montrer CD244 Anticorps) functional assay allows identification of all cases

  6. Molecular dynamics analysis revealed that mutant R32Q and T53I structures of SAP (Montrer APCS Anticorps) exhibited structural variation with respect to their backbone atoms before and after binding with the unphosphorylated SLAM (Montrer SLAMF1 Anticorps) peptide.

  7. Signaling lymphocytic activation molecule (SLAM)/SLAM (Montrer SLAMF1 Anticorps)-associated protein pathway regulates human B-cell tolerance.

  8. In patients suffering from X-linked lymphoproliferative disease (XLP1), SAP (Montrer APCS Anticorps) is nonfunctional, not only abolishing the activating function of 2B4 (Montrer CD244 Anticorps), but rendering this receptor inhibitory.

  9. our data reveal how SAP (Montrer APCS Anticorps) nucleates a previously unknown signaling complex involving NTB-A (Montrer SLAMF6 Anticorps) and LCK (Montrer LCK Anticorps) to potentiate restimulation-induced cell death of activated human T cells.

  10. SAP (Montrer APCS Anticorps) is a new actor downstream of PECAM-1 (Montrer PECAM1 Anticorps) and its binding regulates PECAM-1 (Montrer PECAM1 Anticorps) mediated cell adhesion.

Mouse (Murine) SH2 Domain Containing 1A (SH2D1A) interaction partners

  1. SAP (Montrer APCS Anticorps) is an essential molecule for autoimmune antibody production.

  2. In addition to their role in NK cell activation by hematopoietic cells, the SLAM-SAP-SHP1 pathways influence responsiveness toward nonhematopoietic targets by a process akin to NK cell 'education'.

  3. SLAM (Montrer SLAMF1 Anticorps)-SAP (Montrer APCS Anticorps) signaling promotes differentiation of IL-17 (Montrer IL17A Anticorps)-producing T cells and progression of experimental autoimmune encephalomyelitis.

  4. these data suggest that SAP (Montrer APCS Anticorps) is critical for regulating type II NKT (Montrer CTSL1 Anticorps) cell responses.

  5. functional analysis in vitro indicates that SAP-2 is a non-functional isoform due to decreased protein stability

  6. Here we report that B cell intrinsic responses to haptenated protein antigens are impaired in SAP (Montrer APCS Anticorps)-/- mice and in Rag-/- mice into which B cells derived from SAP (Montrer APCS Anticorps)-/- mice together with wt CD4 (Montrer CD4 Anticorps)+ T cells had been transferred.

  7. SAP (Montrer APCS Anticorps) plays an essential role in CIA (Montrer NCOA5 Anticorps) because of Fyn (Montrer FYN Anticorps)-independent and Fyn (Montrer FYN Anticorps)-dependent effects on TFH cells and, possibly, other T cell types.

  8. SAP (Montrer APCS Anticorps) was required not only for the initiation but also for the progression of primary T cell-driven B cell responses to haptens.

  9. Loss of SAP (Montrer APCS Anticorps) expression is associated with invariant NKT (Montrer CTSL1 Anticorps) cell cytotoxicity and defective lytic synapse formation.

  10. SAP (Montrer APCS Anticorps) is required for the development of innate phenotype in H2-M3--restricted Cd8 (Montrer CD8A Anticorps)(+) T cells.

SH2 Domain Containing 1A (SH2D1A) profil antigène

Antigen Summary

This gene encodes a protein that plays a major role in the bidirectional stimulation of T and B cells. This protein contains an SH2 domain and a short tail. It associates with the signaling lymphocyte-activation molecule, thereby acting as an inhibitor of this transmembrane protein by blocking the recruitment of the SH2-domain-containing signal-transduction molecule SHP-2 to its docking site. This protein can also bind to other related surface molecules that are expressed on activated T, B and NK cells, thereby modifying signal transduction pathways in these cells. Mutations in this gene cause lymphoproliferative syndrome X-linked type 1 or Duncan disease, a rare immunodeficiency characterized by extreme susceptibility to infection with Epstein-Barr virus, with symptoms including severe mononucleosis and malignant lymphoma. Multiple transcript variants encoding different isoforms have been found for this gene.

Alternative names and synonyms associated with SH2 Domain Containing 1A (SH2D1A)

  • SH2 domain containing 1A (SH2D1A) anticorps
  • SH2 domain containing 1A (Sh2d1a) anticorps
  • SH2 domain protein 1A (Sh2d1a) anticorps
  • SH21A (LOC780420) anticorps
  • DSHP anticorps
  • EBVS anticorps
  • Gm686 anticorps
  • IMD5 anticorps
  • LYP anticorps
  • MTCP1 anticorps
  • RGD1562408 anticorps
  • SAP anticorps
  • SAP/SH2D1A anticorps
  • SH2D1A anticorps
  • XLP anticorps
  • XLPD anticorps

Protein level used designations for SH2D1A

Duncan disease SH2-protein , SH2 domain-containing protein 1A , SLAM associated protein/SH2 domain protein 1A , SLAM-associated protein , T cell signal transduction molecule SAP , T-cell signal transduction molecule SAP , signaling lymphocyte activation molecule-associated protein , signaling lymphocytic activation molecule-associated protein , SH2 domain protein 1A , SH2 domain protein 1A, Duncan's disease (lymphoproliferative syndrome) , Signaling lymphocytic activation molecule-associated protein , Duncan disease homolog

4068 Homo sapiens
501502 Rattus norvegicus
613356 Bos taurus
574156 Macaca mulatta
20400 Mus musculus
780420 Sus scrofa
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