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High CDK19 expression is associated with osteosarcoma.
On stimulation of TLR9 (Montrer TLR9 Kits ELISA), CDK8 (Montrer CDK8 Kits ELISA)/19 positively regulates inflammatory gene transcription in cooperation with NF-kappaB (Montrer NFKB1 Kits ELISA) and C/EBPbeta (Montrer CEBPB Kits ELISA).
Data suggest that, during neurogenesis, Mediator complex cyclin (Montrer PCNA Kits ELISA)-dependent kinases (CDK8 (Montrer CDK8 Kits ELISA), CDK19) interact directly with PRC2 (polycomb (Montrer CBX2 Kits ELISA) repressive complex 2) subunit EZH2 (enhancer of zeste homolog 2 (Montrer EZH2 Kits ELISA)), as well as SUZ12 (suppressor of zeste 12 homolog (Montrer SUZ12 Kits ELISA)).
Mediator-associated kinases CDK8 (Montrer CDK8 Kits ELISA) and CDK19 restrain increased activation of key super-enhancer-associated genes in acute myeloid leukaemia (AML (Montrer RUNX1 Kits ELISA)) cells
Microarrays identified target genes for each CDK (Montrer CDK4 Kits ELISA), and we selected six genes: two target genes of CDK8 (Montrer CDK8 Kits ELISA), two target genes of CDK19 and two genes that were targets for both.
CDK8 (Montrer CDK8 Kits ELISA) and CDK19, individually interact with PRMT5 (Montrer PRMT5 Kits ELISA) and WDR77 (Montrer WDR77 Kits ELISA), and their interactions with PRMT5 (Montrer PRMT5 Kits ELISA) cause transcriptional repression of C/EBPbeta (Montrer CEBPB Kits ELISA) target genes.
This gene encodes a protein that is one of the components of the Mediator coactivator complex. The Mediator complex is a multiprotein complex required for transcriptional activation by DNA binding transcription factors of genes transcribed by RNA polymerase II. The protein encoded by this gene is similar to cyclin-dependent kinase 8 which can also be a component of the Mediator complex.
CDC2-related protein kinase 6
, CDK8-like cyclin-dependent kinase
, cell division cycle 2-like 6 (CDK8-like)
, cell division cycle 2-like protein kinase 6
, cell division protein kinase 19
, cyclin dependent kinase 19 variant 2
, cyclin-dependent kinase (CDC2-like) 11
, cyclin-dependent kinase 11
, death-preventing kinase
, cyclin-dependent kinase 8