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anti-Mouse (Murine) CTGF Anticorps:
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Human Polyclonal CTGF Primary Antibody pour IHC (p), WB - ABIN3042771
Li, Zhang, Wang, Zheng, Chen: Nicousamide blocks the effects of advanced glycation end products on renal cells. dans European journal of pharmacology 2012
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Human Polyclonal CTGF Primary Antibody pour ICC, IF - ABIN152147
Alfaro, Deskins, Wallus, DasGupta, Davidson, Nanney, A Guney, Gannon, Young: A physiological role for connective tissue growth factor in early wound healing. dans Laboratory investigation; a journal of technical methods and pathology 2012
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Human Polyclonal CTGF Primary Antibody pour IF (p), IHC (p) - ABIN672636
Tian, Lv, Yang, Zhang, Yu, Zhu, Xiao, Zhu: Effects of vitamin D on renal fibrosis in diabetic nephropathy model rats. dans International journal of clinical and experimental pathology 2014
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Human Polyclonal CTGF Primary Antibody pour ELISA, WB - ABIN2473120
Sánchez de la Muela, Zudaire, Robles, Rosell, Aguera, De Castro, Isa, Berián: [Survival analysis in renal cell carcinoma with invasion of the vena cava]. dans Actas urologicas españolas 1991
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Human Polyclonal CTGF Primary Antibody pour Func, IF - ABIN2473119
Moussad, Brigstock: Connective tissue growth factor: what's in a name? dans Molecular genetics and metabolism 2000
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Human Monoclonal CTGF Primary Antibody pour ELISA, WB - ABIN514745
Polacek, Bruun, Johansen, Martinez: Comparative Analyses of the Secretome from Dedifferentiated and Redifferentiated Adult Articular Chondrocytes. dans Cartilage 2015
Human Polyclonal CTGF Primary Antibody pour IHC, IHC (p) - ABIN4300783
Livingston, Ding, Huang, Hill, Yin, Dong: Persistent activation of autophagy in kidney tubular cells promotes renal interstitial fibrosis during unilateral ureteral obstruction. dans Autophagy 2016
Human Polyclonal CTGF Primary Antibody pour WB - ABIN223605
Chen, Lan, Zhou, Li, Zhang, Zhang, Yang, Li: Astilbin attenuates hyperuricemia and ameliorates nephropathy in fructose-induced hyperuricemic rats. dans Planta medica 2011
These data suggest that CTGF levels are increased in multiple organs after radiation exposure and that inflammatory cell infiltration may contribute to the elevated levels of CTGF in multiple organs.
During vascular regression, Yap/Taz is activated by blood circulation in the endothelial cells. This leads to induction of Ctgf and actin polymerization. Interference with Yap/Taz activation decreased Ctgf production, which decreased actin polymerization and vascular regression.
this study reveals that CTGF is necessary and sufficient to stimulate glial bridging and natural spinal cord regeneration.
CTGF/CCN2 plays an important role in notochord development and is required for general embryonic development
this study suggested that CTGF antibody protected podocytes against injury in DN mice by reducing beta-catenin (Montrer CTNNB1 Anticorps) overexpression and preventing podocyte EMT (Montrer ITK Anticorps), which might provide new insight into the mechanism of CTGF inhibition in the treatment of DN.
LPA-LPA1 (Montrer LPAR1 Anticorps) signaling initiates profibrotic epithelial cell fibroblast communication mediated by epithelial cell derived connective tissue growth factor.
Down-regulation of CTGF is effective in inhibiting postoperative scarring in vivo. This suggests that RNAi with CTGF siRNA may potentially pave the road for a novel therapeutic strategy to improve glaucoma surgery results.
CTGF role in cardiac fibrosis. Long noncoding RNA H19 (Montrer NCKAP1 Anticorps) mediates CTGF expression.
Notch1 (Montrer NOTCH1 Anticorps) haploinsufficiency decreased the expression of Ctgf in the aorta and in vitro cell culture system. In vitro studies on SMCs using the Notch1 (Montrer NOTCH1 Anticorps) intracellular domain (NICD (Montrer NOTCH1 Anticorps)) plasmid, dominant negative mastermind-like (dnMAML), or specific siRNA suggest that Notch1 (Montrer NOTCH1 Anticorps), not Notch3 (Montrer NOTCH3 Anticorps), directly modulates the expression of CTGF
these findings show that cardiac ERK1/2 (Montrer MAPK1/3 Anticorps) activity is modulated in part by TGF-b/Smad (Montrer SMAD1 Anticorps) signaling, leading to altered activation of CTGF/CCN2 to mediate fibrosis and alter cardiac function. This identifies a novel mechanism in the development of LMNA (Montrer LMNA Anticorps) cardiomyopathy.
the mechanistic target of rapamycin (mTOR (Montrer FRAP1 Anticorps)) pathway in neurons regulates CTGF production and secretion, revealing a paracrine mechanism by which neuronal signaling regulates oligodendrocyte maturation and myelination in tuberous sclerosis complex (TSC (Montrer SLC12A3 Anticorps)).
CCN2 suppression by miR (Montrer MLXIP Anticorps)-199a-5p accounts, in part, for low-level fibrogenic gene expression in quiescent hepatic stellate cells (HSCs) and causes dampened gene expression in activated HSCs after horizontal transfer of miR (Montrer MLXIP Anticorps)-199a-5p in exosomes from quiescent HSCs.
In summary, our data suggest that in obstructive nephropathy atrophy increases and fibrosis decreases with age and that this relates to increased BMP signaling, most likely due to higher BMP6 (Montrer BMP6 Anticorps) and lower CTGF expression.
Overexpression of CTGF in cardiomyocytes attenuates left ventricular hypertrophy in angiotensin II induced hypertension.
Data suggested that the co-expression of the Hippo transducers TAZ (Montrer TAZ Anticorps)/YAP (Montrer YAP1 Anticorps) and CTGF may be an adverse prognostic factor in male breast cancer.
These findings suggest that 5-HT (Montrer DDC Anticorps) promotes CCN2 production through the 5-HT2AR in growth plates, and that it represses CCN2 production through the 5-HT2BR in articular cartilage for harmonized development of long bones
In addition to well-known anti-inflammatory features, glucocorticoids may have adverse effects on long-term remodeling by TGF-beta1 (Montrer TGFB1 Anticorps)-independent induction of CTGF in lung cells. Simultaneous treatment with caffeine may attenuate glucocorticoid-induced expression of CTGF, thereby promoting restoration of lung homeostasis.
CytoD modified MKL1, a coactivator of serum response factor (SRF) regulating CTGF induction, and promoted its nuclear localization.
CTGF silencing aggravated energy stress induced by hyperthermia and enhanced apoptosis of hyperthermia-resistant cancers.
In lesional SSc (Montrer CYP11A1 Anticorps) dermal fibroblasts, GKT-137831 reduced alpha-SMA (Montrer SMN1 Anticorps) and CCN2 protein overexpression and collagen gel contraction
High glucose-induced cytoplasmic translocation of Dnmt3a (Montrer DNMT3A Anticorps) contributes to CTGF hypo-methylation in mesangial cells.
Results demonstrat that GDF8 (Montrer MSTN Anticorps) stimulates the expression and secretion of CTGF in human granulosa cells and provide evidence that both proteins may play critical roles in the regulation of extracellular matrix formation in these cells.
combined inhibition of ALK5 (Montrer TGFBR1 Anticorps) and CTGF is required to prevent TGFbeta (Montrer TGFB1 Anticorps)-induced nodule formation in tri (Montrer VANGL2 Anticorps)-cellular cultures
YAP (Montrer YAP1 Anticorps)/TAZ (Montrer TAZ Anticorps) and Smad2 (Montrer SMAD2 Anticorps) regulate CTGF expression in tubular epithelial cells. Reduced nuclear Smad2 (Montrer SMAD2 Anticorps) correlated with impaired CTGF secretion in DMOG-treated cells and transient downregulation of Smad2 (Montrer SMAD2 Anticorps) interfered with TGFbeta (Montrer TGFB1 Anticorps)-1-induced CTGF synthesis. YAP (Montrer YAP1 Anticorps) is an indispensable transcription factor involved in CTGF synthesis.
CCN2 was transiently expressed at the leading keratinocyte edge in wound healing.
Atrial fibrillation patients and animals exhibited a significantly increased expression of connective tissue growth factor (CTGF). Angiotension II-induced CTGF expression might be involved in atrial substrate remodeling.
CTGF in trabecular meshwork is modulated by physiological agonists and by increased ocular pressure and mechanical stretch. Regulation of CTGF within outflow pathway may play role in homeostasis of intraocular pressure.
CTGF level was not altered in model of obliterative bronchiolitis.
The results indicate that CTGF suppresses the synthesis of biglycan (Montrer BGN Anticorps) but newly induced that of decorin (Montrer DCN Anticorps) in the cells when the cell density is low.
Actin cytoskeleton-dependent regulation of CTGF transcription and mRNA stability
A significant increase in TGF-beta1 (Montrer TGFB1 Anticorps) and CTGF was found at 6 weeks in the subsynovial connective tissue in a rabbit model of carpal tunnel syndrome.
Stretch is an important primary trigger for CTGF-induction in the overloaded heart.
Connective tissue growth factor is expressed in the naive cornea, lens, iris, and retina, and is expressed immediately after epithelial injury. Loss of CTGF impairs efficient re-epithelialization of corneal wounds.
TGF-beta1 (Montrer TGFB1 Anticorps) can inhibit the growth of urethra epithelium cells and induce the expression of CTGF.
Overexpression of CTGF in the blebs after trabeculectomy demonstrates that CTGF may play an important role in the process of wound healing.
Recombinant CTGF added to embryonic mouse neural precursor cell culture increased the number of Sox-2 (Montrer SOX2 Anticorps)-, GFAP (Montrer GFAP Anticorps)-and GFAP (Montrer GFAP Anticorps)/Nestin (Montrer NES Anticorps)-positive cells, activated p44 (Montrer GTF2H2 Anticorps)/42 signaling, and upregulated fibronectin (Montrer FN1 Anticorps). In human glioma cells, it induced GFAP (Montrer GFAP Anticorps) and nestin (Montrer NES Anticorps).
Data show that connective-tissue growth factor regulates signalling through the Wnt (Montrer WNT2 Anticorps) pathway, in accord with its ability to bind to the Wnt (Montrer WNT2 Anticorps) co-receptor LDL receptor (Montrer LDLR Anticorps)-related protein 6 (LRP6 (Montrer LRP6 Anticorps)).
The protein encoded by this gene is a mitogen that is secreted by vascular endothelial cells. The encoded protein plays a role in chondrocyte proliferation and differentiation, cell adhesion in many cell types, and is related to platelet-derived growth factor. Certain polymorphisms in this gene have been linked with a higher incidence of systemic sclerosis.
WNT1 inducible signaling pathway protein 2
, connective tissue growth factor
, Connective tissue growth factor
, connective tissue growth factor-like
, CCN family member 2
, Connective tissue growth factor precursor (CTGF) (FISP-12 protein) (Hypertrophic chondrocyte-specific protein 24)
, fibroblast inducible secreated protein
, fibroblast inducible secreted protein
, hypertrophic chondrocyte-specific gene product 24
, hypertrophic chondrocyte-specific protein 24
, IGF-binding protein 8
, insulin-like growth factor-binding protein 8
, connective tissue growth-related protein
, connective tissue growth factor XCTGF