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Targeted knockdown of the integrin focal adhesion complex components beta-integrin, PINCH (Montrer LIMS1 Kits ELISA), and integrin-linked kinase caused formation of multinucleate epidermal cells within the Drosophila larval epidermis.
PINCH (Montrer LIMS1 Kits ELISA) and ILK have an independent capacity to localize at muscle attachment sites in vivo.
ILK functions as an essential hub in the assembly of its partner proteins at sites of integrin adhesion.
We conclude that ILK is critical for maintaining the collecting duct epithelium and renal function and is a key intermediate for periostin (Montrer POSTN Kits ELISA) activation of signaling pathways involved in cyst growth and fibrosis in PKD (Montrer PRKD1 Kits ELISA).
Ilk and ELMO2 (Montrer ELMO2 Kits ELISA) modulate recycling endosomes in keratinocytes undergoing intercellular adhesion mediated through cell-cell contacts, including E-cadherin (Montrer CDH1 Kits ELISA)-based adherens junctions.
Ilk regulates cellular mechanics facilitating the motility in 3D extracellular matrices.
It was concluded that ILK depletion modifies the transcription of GLUT4 (Montrer SLC2A4 Kits ELISA), which results in reduced peripheral insulin (Montrer INS Kits ELISA) sensitivity and glucose uptake, suggesting ILK as a molecular target and a prognostic biomarker of insulin (Montrer INS Kits ELISA) resistance.
results demonstrate that TGF-beta1 (Montrer TGFB1 Kits ELISA)-induced autophagy links beta-catenin (Montrer CTNNB1 Kits ELISA) and Smad (Montrer SMAD1 Kits ELISA) signaling to promote epithelial-mesenchymal transition in C1.1 cells through a novel pY654-beta-catenin (Montrer CTNNB1 Kits ELISA)/p-Smad2 (Montrer SMAD2 Kits ELISA)/ILK pathway.
ILK deletion impaired the developmental profile, proliferation, and differentiation of oligodendrocyte precursor cells.
Our results define ILK as a key mechanotransducer in modulating breast cancer stem-like cells development in response to tissue mechanics and oxygen tension.
iNOS (Montrer NOS2 Kits ELISA)-derived NO plays a crucial role during atherosclerosis by regulating the endocytic-lysosomal degradation of ILK in endothelial cells.
Hepatic ILK deletion has no effect on insulin (Montrer INS Kits ELISA) action in lean mice but sensitizes the liver to insulin (Montrer INS Kits ELISA) during the challenge of high fat feeding. This effect corresponds to changes in the expression and activation of key insulin (Montrer INS Kits ELISA) signaling pathways as well as a greater capacity for hepatic mitochondrial glucose oxidation.
this study has identified a new role for Parvin (Montrer PARVA Kits ELISA) and alphaPix (Montrer ARHGEF6 Kits ELISA) downstream of the integrin-ILK signaling axis for mammary epithelial cell differentiation.
Heart failure in recessive embryonic lethal zebrafish mutant main squeeze (msq) mutants is due to a mutation in the integrin-linked kinase (ilk) gene.
The lost-contact mutant on chromosome 10 encodes a nonsense mutation (Y319X) associated with defective cardiomyocytes & endothelial cells that leads to severe myocardial dysfunction. There is epistatic regulation between laminin-alpha4, integrin, & Ilk.
Data show that integrin-linked kinase is an essential component downstream of laminin and integrin alpha7, providing strengthening of skeletal muscle fibre adhesion with the extracellular matrix.
Emodin inhibits the migration and invasion abilities of human endometrial stromal cells by by facilitating the mesenchymal-epithelial transition through targeting integrin-linked kinase.
KRAS-E2F1-ILK-hnRNPA1 regulatory loop enables pancreatic cancer cells to promote oncogenic KRAS signaling and to interact with the tumor microenvironment to promote aggressive phenotypes.
Data indicate a regulatory role for tetraspanin 8 (Tspan8 (Montrer TSPAN8 Kits ELISA)) in melanoma progression by modulating cell-matrix interactions through beta1 integrin - integrin-linked kinase (ILK) axis and establish Tspan8 (Montrer TSPAN8 Kits ELISA) as a negative regulator of ILK activity.
Overexpression of ILK therefore promoted the proliferation of SHG44 human glioma cells, reduced apoptosis and reduced sensitivity to TMZ via decreasing the activity of caspase3.
Using in vitro studies, we demonstrated that ILK and PI3K (Montrer PIK3CA Kits ELISA)/AKT (Montrer AKT1 Kits ELISA) inhibitors suppressed the contraction of fibroblast-populated collagen lattices, inhibited fibroblast migration, and interrupted the effect of TGF-beta1 (Montrer TGFB1 Kits ELISA) on promoting alpha smooth muscle actin (Montrer ACTG2 Kits ELISA) (alpha-SMA (Montrer SMN1 Kits ELISA)) expression in fibroblasts.
During human endometrial decidualization, ILK is essential for morphologic transformation of endometrial stromal cells through organization of the actin cytoskeleton.
These data suggest a novel link between Tiam1 and RhoG/ILK /ELMO2 pathway as upstream effectors of the Rac1-mediated phagocytic process in trabecular meshwork cells.
Integrin-linked kinase (ILK, MGC129022) is an important regulator of the endothelial phenotype and vascular network formation by directing the assembly and/or maturation of alpha5beta1-competent matrix-forming adhesions.
Rac1 only partially restores the spreading defects of integrin linked kinasse (ILK)-depleted cells, suggesting that an additional ILK-dependent signal is required for cell spreading.
Profilin (Montrer PFN1 Kits ELISA)-dependent dissociation of G-actin (Montrer ACTB Kits ELISA)-Tbeta4 complexes simultaneously liberates actin for filament assembly and facilitates Tbeta4 binding to integrin-linked kinase (ILK) in the lamellipodia.
Transduction of extracellular matrix signals through integrins influences intracellular and extracellular functions, and appears to require interaction of integrin cytoplasmic domains with cellular proteins. Integrin-linked kinase (ILK), interacts with the cytoplasmic domain of beta-1 integrin. This gene encodes a serine/threonine protein kinase with 4 ankyrin-like repeats, which associates with the cytoplasmic domain of beta integrins and acts as a proximal receptor kinase regulating integrin-mediated signal transduction. Multiple alternatively spliced transcript variants encoding the same protein have been found for this gene.
, Integrin-linked kinase
, integrin linked kinase
, integrin-linked protein kinase
, integrin-linked kinase
, Integrin-linked protein kinase
, integrin binding protein kinase
, main squeeze
, beta-integrin-linked kinase
, 59 kDa serine/threonine-protein kinase
, integrin-linked kinase-2