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Concentrating on hypermethylated genes to identify candidate tumor suppressor loci, the study found the cell engulfment and adhesion factor gene MEGF10 to be epigenetically repressed by DNA hypermethylation or by H3K27/K9 methylation in neuroblastoma (Montrer ARHGEF16 Kits ELISA) cell lines.
MEGF10 mutations can cause myopathy with adult-onset respiratory insufficiency
results indicate that myogenin (Montrer MYOG Kits ELISA) is a positive regulator in transcriptional regulation of MEGF10 in skeletal muscle
Mutations in MEGF10 cause a recessive congenital myopathy with minicores and suggest satellite cell dysfunction as the pathogenic mechanism
Mutations in MEGF10, a regulator of satellite cell myogenesis, cause early onset myopathy, areflexia, respiratory distress and dysphagia (EMARDD)
The results of this study suggested that no association between schizophrenia and rs27388 of the MEGF10 gene in Chinese case-control sample.
MEGF10 is involved in the uptake of amyloid-beta peptide (Abeta42) in the brain.
in a system of forced expression by transfection, MEGF10 function can be modulated by the ATP binding cassette transporter ABCA1, ortholog to CED-7
Human MEGF10 is an ortholog of Ced1 (Montrer IFT122 Kits ELISA).
An interaction between MEGF10 and clathrin assembly protein complex 2 medium chain (AP50 (Montrer AP2M1 Kits ELISA)), a component of clathrin-coated pits was identified.
Megf10 binds with high affinity to C1q, an eat-me signal for apoptotic cells. Cells expressing Megf10 with EMARDD mutations have impaired apoptotic cell clearance and impaired binding to C1q.
studies reveal a novel role for astrocytes in mediating synapse elimination in the developing and adult brain, identify MEGF10 and MERTK (Montrer MERTK Kits ELISA) as critical proteins in the synapse remodelling underlying neural circuit refinement
Cysteine mutations cause defective tyrosine phosphorylation in MEGF10 myopathy.
These results indicated that both Jedi-1 (Montrer PEAR1 Kits ELISA) and MEGF10 can mediate phagocytosis independently through the recruitment of Syk (Montrer SYK Kits ELISA).
in mouse, two related transmembrane proteins, MEGF10 and MEGF11, have critical roles in the formation of mosaics by two retinal interneuron subtypes, starburst amacrine cells and horizontal cells
Megf10 represents a novel transmembrane protein that impinges on Notch (Montrer NOTCH1 Kits ELISA) signaling to regulate the satellite cell population balance between proliferation and differentiation.
This gene encodes a member of the multiple epidermal growth factor-like domains protein family. The encoded protein plays a role in cell adhesion, motility and proliferation, and is a critical mediator of apoptotic cell phagocytosis as well as amyloid-beta peptide uptake in the brain. Expression of this gene may be associated with schizophrenia, and mutations in this gene are a cause of early-onset myopathy, areflexia, respiratory distress, and dysphagia (EMARDD) as well as congenital myopathy with minicores. Alternatively spliced transcript variants have been observed for this gene.
multiple epidermal growth factor-like domains protein 10
, multiple EGF-like domains protein 10