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Human Polyclonal RCAN1 Primary Antibody pour WB - ABIN390298
Hirakawa, Nary, Medh: Glucocorticoid evoked upregulation of RCAN1-1 in human leukemic CEM cells susceptible to apoptosis. dans Journal of molecular signaling 2009
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Mouse (Murine) Polyclonal RCAN1 Primary Antibody pour ELISA, WB - ABIN4349720
Lee, Garvey, Baras, Lemmon, Gomez, Schoppee Bortz, Daum, LeBoeuf, Wamhoff: Integrative genomics identifies DSCR1 (RCAN1) as a novel NFAT-dependent mediator of phenotypic modulation in vascular smooth muscle cells. dans Human molecular genetics 2009
Human Monoclonal RCAN1 Primary Antibody pour ELISA, WB - ABIN515078
Qin, Zhao, Liu, Nagy, Hoang, Brown, Dvorak, Zeng: Down syndrome candidate region 1 isoform 1 mediates angiogenesis through the calcineurin-NFAT pathway. dans Molecular cancer research : MCR 2006
Human Monoclonal RCAN1 Primary Antibody pour IF, ELISA - ABIN515079
Xing, Salas, Zhang, Gittler, Ludwig, Lin, Murty, Silverman, Arancio, Tycko: Creation and characterization of BAC-transgenic mice with physiological overexpression of epitope-tagged RCAN1 (DSCR1). dans Mammalian genome : official journal of the International Mammalian Genome Society 2013
Cow (Bovine) Polyclonal RCAN1 Primary Antibody pour WB - ABIN2780590
Riper, Jayakumar, Latchana, Bhoiwala, Mitchell, Valenti, Crawford: Regulation of vascular function by RCAN1 (ADAPT78). dans Archives of biochemistry and biophysics 2008
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RCAN1-regulated vascular branching which may play a role in the patterning of morphologically different vasculature.
Overexpression of RCAN1 markedly reduced glioma cells viability.
RCAN1.4 prevents cell proliferation, migration, and invasion in vitro; overexpressed RCAN1.4 in HCC (Montrer FAM126A Anticorps) cells prevents growth, angiogenesis, and metastases of xenograft tumors by inhibiting calcineurin activity and nuclear translocation of NFAT1 (Montrer NFAT1 Anticorps).
elucidated a novel function of regulator of calcineurin 1 isoform 1 in mitochondria and provides a molecular basis for the regulator of calcineurin 1 isoform over-expression-induced mitochondrial dysfunctions and neuronal apoptosis
our research revealed that RCAN1 was involved in the development of small cell lung cancer, and it might be a cancer-inhibiting gene for the formation of bone metastases in small cell lung cancer
The results of the study indicate that RCAN1 is suppressed in endothelial cells of chronically inflamed periodontal tissues. During an acute infection, however, rcan1 seems to be upregulated in endothelial cells, indicating a modulating role in immune homeostasis of periodontal tissues.
mRNA expression levels of DSCR1 and VEGF-C (Montrer VEGFC Anticorps), and microvessel density are increased in cancerous tissues, compared with paracancerous tissue in hypopharyngeal cancer.
DSC1 expression is significantly downregulated in human masticatory mucosa during wound healing
Increased expression of DSC1 can promote the occurrence of head and neck squamous cell carcinoma (HNSCC) and is associated with tumor. The increased expression of DSC1 also indicates a poor prognosis of the patients with HNSCC.
The objective of this study was aimed to detect the association of Down syndrome critical region 1 (DSCR1) gene polymorphisms (rs149048873 and rs143081213) and congenital heart disease (CHD (Montrer CHDH Anticorps)) susceptibility.
Results support overexpression of RCAN1 and particularly the RCAN1.1S isoform during aging as a pathogenic mechanism in both Down syndrome-related and sporadic Alzheimer's disease
The present study demonstrates that RCAN1 deficiency protects against Salmonella intestinal infection by enhancing proinflammatory JNK (Montrer MAPK8 Anticorps) signaling.
DSCR1 as a key protein that couples axon growth.
from amongst the myriad of gene expression changes occurring in Type 2 diabetes (T2D) b-cells where we had little knowledge of which changes cause b-cell dysfunction, we applied a trisomy 21 screening approach which linked RCAN1 to b (Montrer TDO2 Anticorps)-cell mitochondrial dysfunction in T2D.
These results uncover a critical link between calcineurin signalling, impaired neurotrophin (Montrer BDNF Anticorps) trafficking and neurodevelopmental deficits in the peripheral nervous system in Down syndrome.
Data suggest that expression of Dscr1 in hippocampus can be regulated by dietary factors; supplementation of maternal diet and offspring diet with fish oil down-regulates Dscr1 in hippocampus of offspring; Dscr1 is a presumed target in Down syndrome.
inhibition of the calcineurin-nuclear factor of activated T cells pathway enhances the proliferation of granulocyte-monocyte progenitors both in vitro and in vivo
PACAP (Montrer ADCYAP1 Anticorps) targets RCAN1 to control neuronal differentiation.
We also confirmed that overexpression of RCAN1-1L could inhibit the transcriptional activation of an NFAT-dependent promoter in response to PMA and ionomycin by inhibiting Calcineurin activity in HEK293T cells
found that RCAN1/3 interact with RAF (Montrer RAF1 Anticorps) kinases and CN in a non-exclusive manner. Our data suggests that the balance of RCAN interactions with CN and/or RAF (Montrer RAF1 Anticorps) kinases may influence T cell positive selection
Calcineurin and its regulator, RCAN1, confer time-of-day changes in susceptibility of the heart to ischemia/reperfusion.
The protein encoded by this gene interacts with calcineurin A and inhibits calcineurin-dependent signaling pathways, possibly affecting central nervous system development. This gene is located in the minimal candidate region for the Down syndrome phenotype, and is overexpressed in the brain of Down syndrome fetuses. Chronic overexpression of this gene may lead to neurofibrillary tangles such as those associated with Alzheimer disease. Three transcript variants encoding three different isoforms have been found for this gene.
regulator of calcineurin 1
, Down syndrome critical region gene 1
, cadherin family member 1
, desmosomal glycoprotein 2/3
, down syndrome critical region protein 1
, Down syndrome candidate region 1
, calcium and oxidant-inducible mRNA
, modulatory calcineurin-interacting protein 1
, myocyte-enriched calcineurin-interacting protein 1
, near DSCR proline-rich protein
, Down syndrome critical region homolog 1
, calcineurin inhibitor
, calcipressin 1
, down syndrome critical region protein 1 homolog
, myocyte-enriched calcineurin interactin protein 1
, Down syndrome critical region protein 1 homolog
, Oxidative-induced protein Adapt78