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significant co-localization of binding sites for MyoD (Montrer MYOD1 Kits ELISA) and Six proteins on over a thousand mouse genomic DNA regions, were found.
The results indicated that low Six4 and Six5 gene dosage improved dystrophic phenotypes of Dmd(mdx (Montrer DMD Kits ELISA)) /Y mice by enhancing muscle regeneration, and suggested that SIX4 and SIX5 are potentially useful de novo targets in therapeutic applications against muscle disorders, including DMD (Montrer DMD Kits ELISA).
results reveal a role for Six4 during adult muscle regeneration and suggest a widespread mechanism of cooperation between Six4 and MyoD (Montrer MYOD1 Kits ELISA).
the transcription factors Six1 (Montrer SIX1 Kits ELISA) and Six4 are required for male gonadal differentiation.
Direct molecular regulation of the myogenic determination gene Myf5 (Montrer MYF5 Kits ELISA) by Pax3 (Montrer PAX3 Kits ELISA), with modulation by Six1 (Montrer SIX1 Kits ELISA)/4 factors, is exemplified by the -111 kb-Myf5 (Montrer MYF5 Kits ELISA) enhancer
Data show that absence of Six1 (Montrer SIX1 Kits ELISA) and Six4 leads to the development of dorsal myofibers lacking expression of fast-type muscle genes, and mainly expressing a slow-type muscle program.
These results suggest that Six1 (Montrer SIX1 Kits ELISA) and Six4 genes are expressed in the taste bud cells, in newly formed or surviving type-II cells.
Six4 and Six5 repressed, while Six1 (Montrer SIX1 Kits ELISA) activated myogenin (Montrer MYOG Kits ELISA) expression, suggesting that the differential regulation of myogenin (Montrer MYOG Kits ELISA) expression is responsible for the differential effects of Six genes
Six1 (Montrer SIX1 Kits ELISA) and Six4 expression is required to specifically activate fast-type muscle genes
Data show that Six4 is transcriptional regulatory element X (TrexBF) in skeletal myocytes and transactivates the muscle creatine kinase (Montrer CKM Kits ELISA) enhancer.
This gene encodes a member of the homeobox family, subfamily SIX. The drosophila homolog is a nuclear homeoprotein required for eye development. Studies in mouse show that this gene product functions as a transcription factor, and may have a role in the differentiation or maturation of neuronal cells.
homeobox protein SIX4
, sine oculis homeobox homolog 4
, sine oculis-related homeobox 4 homolog
, skeletal muscle-specific ARE-binding protein AREC3