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Human Polyclonal ALDH1A2 Primary Antibody pour IHC, IHC (p) - ABIN4279209
Kostareli, Holzinger, Bogatyrova, Hielscher, Wichmann, Keck, Lahrmann, Grabe, Flechtenmacher, Schmidt, Seiwert, Dyckhoff, Dietz, Höfler, Pawlita, Benner, Bosch, Plinkert, Plass, Weichenhan, Hess: HPV-related methylation signature predicts survival in oropharyngeal squamous cell carcinomas. dans The Journal of clinical investigation 2013
Show all 4 Pubmed References
Data show that hRALDH2 is not inhibited by its oxidation product, all-trans-RA, suggesting the absence of a negative feedback regulatory loop. Expression of the Raldh2 gene is known to be regulated by RA itself, suggesting that the main regulation of the hRALDH2 activity level is transcriptional.
Study shows no evidence that genetic variants alter prostate cancer incidence, but show that SNPs in the ALDH1A2 gene affect prostate cancer mortality.
a critical role of ALDH1A2-RAR (Montrer RARA Anticorps) signaling in the pathogenesis of head and neck cancer.
High expression of ALDH1A2 and ALDH1B1 (Montrer ALDH1B1 Anticorps) mRNA was found to be significantly correlated to worser survival in all NSCLC patients.
the distribution of RALDH1 (Montrer ALDH1A1 Anticorps), RALDH2, and RALDH3 (Montrer ALDH1A3 Anticorps) in the postnatal eye was determined.
ALDH1A2 is involved in the regulation of cancer stem cell properties in neuroblastoma (Montrer ARHGEF16 Anticorps).
Genetic association replicative and exploratory studies identify SNPs in ADA (Montrer ADA Anticorps) and MTR (Montrer MTR Anticorps) highly associated with isolated Neural tube defects (NTD)and SNP in ARID1A (Montrer ARID1A Anticorps) and ALDH1A2 associated with NTDs in whites and African Americans respectively.
At the transcript level, the cisplatin + DEAB-resistant cells showed upregulated mRNA expression levels for ALDH1A2, ALDH1A3 (Montrer ALDH1A3 Anticorps) isozymes and CD44 (Montrer CD44 Anticorps) indicating the involvement of these markers in conferring chemoresistance
DNA methylation (Montrer HELLS Anticorps) at multiple CpG sites is associated with loss of control over alcohol drinking.
Severe osteoarthritis of the hand associates with common variants within the ALDH1A2 gene and with rare variants at 1p31.
Zebrafish foxc1a plays a crucial role in early somitogenesis by restricting the expression of Raldh2 directly.
The novel aldh1a2 reporter line is driven by the complete set of regulatory sequences required for zebrafish development, reports novel sources of RA synthesis, and identifies the source of RA that promotes vertebral ossification.
aldh1a2 participate to a positive loop required for branchial arches development in zebrafish
Aldh1a2 is the primary aldehyde dehydrogenase acting during pancreas development and maternal Aldh1a2 activity persists in aldh1a2(um22) and aldh1a2(i26) mutant embryos.
Studies indicate that raldh2 expression is critical for the formation of wound epithelium and blastema.
these studies identify Notch (Montrer NOTCH1 Anticorps) signaling in dendritic cells as a crucial balancer of Th17/iTreg, which depends on the direct regulation of Aldh1a2 (Montrer ALDH1A1 Anticorps) transcription in dendritic cells
ALDH2 (Montrer ALDH2 Anticorps) mutation displays an inverse correlation of coronary collateral vessel formation in patients.
Data suggest that retinoic acid and GM-CSF (Montrer CSF2 Anticorps)-induced retinal dehydrogenase 2 (RALDH2) expression in dendritic cells requires cooperative binding of transcription factor Sp1 (Montrer SP1 Anticorps) via the RA receptor/retinoid X receptor (Montrer RXRB Anticorps) complex to the Aldh1a2 (Montrer ALDH1A1 Anticorps) promoter.
all three proteins (RDH10 (Montrer RDH10 Anticorps), RALDH2, and CRABP2 (Montrer CRABP2 Anticorps)) appeared to be required for ATRA production induced by activation of PPARgamma (Montrer PPARG Anticorps)
Defects in interdigital programmed cell death and digit separation in Hoxa13 (Montrer HOXA13 Anticorps) mutant mice may be caused in part by reduced levels of RA signaling stemming from a loss in the direct regulation of Aldh1a2 (Montrer ALDH1A1 Anticorps)
Raldh1 (Montrer ALDH1A1 Anticorps) and Raldh3 (Montrer ALDH1A3 Anticorps) influence enteric nervous system structure and function and heterozygosity for Raldh2 causes ENS defects
ALDH1A2 expression was highest in ALDH(very-br) cells, intermediate in ALDH(dim) cells, and lowest in ALDH(br) cells.
Upregulation of retinal dehydrogenase 2 in alternatively activated macrophages during retinoid-dependent type-2 immunity to helminth infection in mice.
rendered Fgfr2IIIb (Montrer FGFR2 Anticorps)(-/-) embryos haploinsufficient for the Raldh2 and examined these embryos for the incidence and severity of duodenal atresia
Expression of ALDH1A2 (Montrer ALDH1A1 Anticorps), BEX2 (Montrer BEX2 Anticorps), EGR2 (Montrer EGR2 Anticorps), CCL3 (Montrer CCL3 Anticorps) and PLAU (Montrer PLAU Anticorps) are upregulated in Toxoplasma gondiisusceptible C57BL/6 mice.
This protein belongs to the aldehyde dehydrogenase family of proteins. The product of this gene is an enzyme that catalyzes the synthesis of retinoic acid (RA) from retinaldehyde. Retinoic acid, the active derivative of vitamin A (retinol), is a hormonal signaling molecule that functions in developing and adult tissues. The studies of a similar mouse gene suggest that this enzyme and the cytochrome CYP26A1, concurrently establish local embryonic retinoic acid levels which facilitate posterior organ development and prevent spina bifida. Four transcript variants encoding distinct isoforms have been identified for this gene.
, aldehyde dehydrogenase 1A2
, aldehyde dehydrogenase family 1 member A2
, aldehyde dehydrogenase family 1, subfamily A2
, retinal dehydrogenase 2
, retinal dehydrogenase, type II
, retinaldehyde-specific dehydrogenase type 2
, retinaldehyde dehydrogenase 2
, alcohol dehydrogenase family 1, subfamily A2
, alcohol dehydrogenase family 1, subfamily A7