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SART1 has a role in IFN-mediated anti-Hepatitis B virus response
Data indicate that mutant VHL (Montrer VHL Kits ELISA) can protect HIF1alpha (Montrer HIF1A Kits ELISA) from SART1-dependent degradation in normoxic conditions, but this protection is lost in hypoxic settings, favoring hypoxia-dependent ccRCC proliferation.
SART1 exerts its anti-Hepatitis C virus action through direct transcriptional regulation for some Interferon (Montrer IFNA Kits ELISA) stimulating genes and alternative splicing for others.
This study identifies SART1 as a previously unidentified regulator of c-FLIP (Montrer CFLAR Kits ELISA) and drug-induced activation of caspase-8 (Montrer CASP8 Kits ELISA).
p110 (Montrer CUX1 Kits ELISA), a novel human U6 snRNP (Montrer LSM2 Kits ELISA) protein and U4/U6 snRNP (Montrer LSM2 Kits ELISA) recycling factor
hypothesize that polymorphic variation within the SART-1 gene may account for individuals developing atopy
hypoxia-associated factor (HAF (Montrer F12 Kits ELISA)), also known as SART1, a protein expressed in proliferating cells, binds and ubiquitinates HIF-1alpha (Montrer HIF1A Kits ELISA) in vitro, and both binding and E3 ligase activity are mediated by HAF (Montrer F12 Kits ELISA) amino acids 654 to 800
SART1(+/-) mice showed significant up-regulation of HIF-1alpha (Montrer HIF1A Kits ELISA) in circulating and liver-infiltrating immune cells
This gene encodes two proteins, the SART1(800) protein expressed in the nucleus of the majority of proliferating cells, and the SART1(259) protein expressed in the cytosol of epithelial cancers. The SART1(259) protein is translated by the mechanism of -1 frameshifting during posttranscriptional regulation\; its full-length sequence is not published yet. The two encoded proteins are thought to be involved in the regulation of proliferation. Both proteins have tumor-rejection antigens. The SART1(259) protein possesses tumor epitopes capable of inducing HLA-A2402-restricted cytotoxic T lymphocytes in cancer patients. This SART1(259) antigen may be useful in specific immunotherapy for cancer patients and may serve as a paradigmatic tool for the diagnosis and treatment of patients with atopy. The SART1(259) protein is found to be essential for the recruitment of the tri-snRNP to the pre-spliceosome in the spliceosome assembly pathway.
, squamous cell carcinoma antigen recognized by T cells
, U4/U6.U5 tri-snRNP-associated protein 1
, squamous-cell carcinoma T-cell-recognized antigen
, U4/U6.U5 tri-snRNP-associated protein 1-like
, u4/U6.U5 tri-snRNP-associated protein 1-like
, IgE autoantigen
, SART1(259) protein
, SART1(800) protein
, SNU66 homolog
, U4/U6.U5 tri-snRNP-associated 110 kDa protein
, small nuclear ribonucleoprotein 110kDa (U4/U6.U5)
, squamous cell carcinoma antigen recognised by T cells
, squamous cell carcinoma antigen recognized by T cells 1
, squamous cell carcinoma antigen recognized by T-cells 1
, hypoxia-associated factor