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DLP (Montrer DMD Kits ELISA) and ASF1 are part of a predeposition complex, which is recruited by XNP (Montrer ATRX Kits ELISA) and is necessary to prevent DNA exposure in the nucleus.
ASF1 cellular levels are tightly controlled by distinct pathways and provide a molecular mechanism for post-translational regulation of dASF1 and hASF1a (Montrer ASF1A Kits ELISA) by TLK (Montrer TLK2 Kits ELISA) kinases.
dASF1 has a direct role in modifying chromatin structure during DNA replication and this function of dASF1 is important for the processivity of the replication machinery.
Asf1 is directed via interactions with sequence-specific complexes to mediate silencing of specific target genes.
Histone chaperones ASF1 and NAP1 (Montrer NAP1L1 Kits ELISA) differentially modulate removal of active histone marks by LID-RPD3 (Montrer HDAC1 Kits ELISA) complexes during NOTCH (Montrer NOTCH1 Kits ELISA) silencing.
high level of SF2, as a novel oncoprotein in RCC (Montrer XRCC1 Kits ELISA), was significantly associated with poor survival in a large cohort of RCC (Montrer XRCC1 Kits ELISA) specimens. Taken together, our study presents a road map for the prediction and validation of miR (Montrer MLXIP Kits ELISA)-766-3p/SF2 axis and thus imparts a therapeutic way for further RCC (Montrer XRCC1 Kits ELISA) progression.
The authors found that RNA recognition motif 1 (RRM1 (Montrer RRM1 Kits ELISA)) in SRSF1 binds PP1 (Montrer PPA1 Kits ELISA) and represses its catalytic function through an allosteric mechanism.
We present a joint atomistic molecular dynamics (MD) and experimental study of two RRM-containing proteins bound with their single-stranded target RNAs, namely the Fox-1 (Montrer A2BP1 Kits ELISA) and SRSF1 complexes.The simulations predict unanticipated specific participation of Arg142 at the protein-RNA interface of the SRFS1 complex, which is subsequently confirmed by NMR and ITC measurements
Using NMR spectroscopy with two separately expressed domains of SRSF1, we showed that several residues in the RNA-binding motif 2 interact with the N-terminal region of the RS domain (RS1 (Montrer RS1 Kits ELISA)).
Especially, in SRSF1 morphants, bone cartilage formation was reduced in the brain and Nkx-2.5 (Montrer NKX2-5 Kits ELISA) expression was dramatically reduced in the heart of SRSF1 morphants. In addition, a dramatic reduction in functional chordin (Montrer CHRD Kits ELISA) RNA in SRSF1 morphants was observed suggesting that chordin (Montrer CHRD Kits ELISA) is one of the targets of SRSF1. Thus, we concluded that SRSF1 is an essential factor for pattern formation including heart, cartilage and germ lay
results strongly support SRSF1 as a prognostic biomarker in SCLC and provide a rationale for personalized therapy in SCLC
NSrp70 (Montrer NSRP1 Kits ELISA) acts as a new molecular counterpart for alternative splicing of target RNA, counteracting SRSF1 and SRSF2 (Montrer SRSF2 Kits ELISA) splicing activity.
we have identified for the first time a potential mechanism that involves the essential splicing factor (Montrer SLU7 Kits ELISA) ASF/SF2 through which morphine regulates splicing specificity of the MOR (Montrer OPRM1 Kits ELISA) encoding gene, OPRM1 (Montrer OPRM1 Kits ELISA).
Global splicing analysis with RNA-seq revealed that exons carrying the hnRNP H (Montrer HNRNPH1 Kits ELISA)-binding GGGGG motif are predisposed to be skipped compared to those carrying the SRSF1-binding GGAGG motif in both human and mouse brains.
We present experimental evidence that splicing factor (Montrer SLU7 Kits ELISA) SRSF1, SRSF2 (Montrer SRSF2 Kits ELISA), U2AF35 (Montrer U2AF1 Kits ELISA), U2AF65 (Montrer U2AF59 Kits ELISA) and KHSRP (Montrer KHSRP Kits ELISA) expression levels in gastrointestinal tract (colon, gastric and pancreatic) tumors differ compare to healthy tissues and in cell lines
The expression levels of three splicing factors, ESRP1 (Montrer ESRP1 Kits ELISA), PTB (Montrer PTBP1 Kits ELISA) and SF2/ASF, are significantly altered during cardiac hypertrophy in mice.
RRP1B suppresses metastatic progression by altering the transcriptome through its interaction with splicing regulators such as SRSF1
Deletion of RRM1 (Montrer RRM1 Kits ELISA) eliminated the splicing activity of SRSF1 and thus cellular transformation.
Specific effects on regulated splicing by SR proteins SRSF1 and SRSF2 (Montrer SRSF2 Kits ELISA) depends on a complex set of relationships with multiple other SR proteins in mammalian genomes.
Treatment with IL-17 (Montrer IL17A Kits ELISA) prolongs the half-life of chemokine (Montrer CCL1 Kits ELISA) CXCL1 (Montrer CXCL1 Kits ELISA) mRNA via the adaptor TRAF5 (Montrer TRAF5 Kits ELISA) and the splicing-regulatory factor SF2 (ASF).
analysis of the miRNA-mediated interaction between leukemia/lymphoma-related factor (LRF (Montrer ZBTB7A Kits ELISA)) and alternative splicing factor/splicing factor (Montrer SLU7 Kits ELISA) 2 (ASF/SF2) affects cell senescence and apoptosis
Disruption of an SF2/ASF-dependent exonic splicing enhancer in SMN2 (Montrer SMN1 Kits ELISA) causes spinal muscular atrophy in the absence of SMN1 (Montrer SMN1 Kits ELISA)
Both hnRNP A1 (Montrer HNRNPA1 Kits ELISA) and alternative splicing factor/splicing factor (Montrer SLU7 Kits ELISA) 2 contents rose in adenomas and during injury-induced hyperplasia compared to control lungs
These results highlight the requirement of Sfrs1-mediated alternative splicing for the survival of retinal neurons, with sensitivity defined by the window of time in which the neuron was generated.
This gene encodes a member of the arginine/serine-rich splicing factor protein family, and functions in both constitutive and alternative pre-mRNA splicing. The protein binds to pre-mRNA transcripts and components of the spliceosome, and can either activate or repress splicing depending on the location of the pre-mRNA binding site. The protein's ability to activate splicing is regulated by phosphorylation and interactions with other splicing factor associated proteins. Multiple transcript variants encoding different isoforms have been found for this gene. In addition, a pseudogene of this gene has been found on chromosome 13.
, anti- silencing function 1
, anti-silencing factor
, splicing factor, arginine/serine-rich 1 (splicing factor 2, alternate splicing factor)
, SR splicing factor 1
, alternative-splicing factor 1
, pre-mRNA-splicing factor SF2, P33 subunit
, splicing factor 2
, splicing factor, arginine/serine-rich 1
, splicing factor arginine/serine-rich 1
, splicing factor, arginine/serine-rich 1B
, pre-mRNA-splicing factor SRp30a
, splicing factor, arginine/serine-rich 1 (ASF/SF2)
, serine/arginine-rich splicing factor 1B
, splicing factor, arginine/serine-rich 1b