Aperçu des produits pour TMC1 (TMC1) Kits ELISA

Full name:
Transmembrane Channel-Like 1 Kits ELISA (TMC1)
Chez www.anticorps-enligne.fr sont 1 Transmembrane Channel-Like 1 (TMC1) Kits ELISA de 1 de différents fournisseurs disponibles. De plus, nous expédions TMC1 Anticorps (11) et TMC1 Protéines (6) et beaucoup plus de produits pour cette protéine. Un total de 19 TMC1 produits sont actuellement listés.
Synonymes:
4933416G09Rik, Beethoven, Bth, CWEA1, DFNA36, DFNB7, DFNB11, dn
list all ELISA KIts Gène GeneID UniProt
TMC1 117531 Q8TDI8
Rat TMC1 TMC1 361739  
Souris TMC1 TMC1 13409 Q8R4P5

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Human Transmembrane Channel-Like 1 (TMC1) interaction partners

  1. a novel TMC1 mutation in exon 20, c.1979C>T, p.P660L, which segregated with prelingual autosomal recessive sensorineural hearing loss, was found.

  2. there is hypo-functional TMC1 mechanotransduction channel activity and other even less damaging variants of TMC1 may be associated with more common mild-to-severe sensorineural hearing loss.

  3. TMC1 has been identified as the causative gene in a six-generation Chinese family with autosomal dominant hearing loss.

  4. The first mutation in the TMC1 gene in the Moroccan population causing non-syndromic hearing loss.

  5. The novel compound heterozygous mutant alleles of TMC1 identified in this study were responsible for the autosomal recessive non-syndromic hearing loss in this Tibetan Chinese family.

  6. one heterozygous, non-synonymous variant was detected, with the SNP causing an amino acid substitution in TMC1 in a Polish family with hearing impairment

  7. TMC1 mutations disrupt hair cell mechanoelectrical transduction and are responsible for DFNA36 and DFNB7/B11. [Review Article]

  8. TMC1 is expressed in the hair cells in inner ear.

  9. Description of the spectrum of mutations in TMC1 in 374 families with autosomal recessive, non-syndromic hearing loss from India.

  10. hearing loss in this family was caused by novel compound heterozygous mutations in TMC1

Mouse (Murine) Transmembrane Channel-Like 1 (TMC1) interaction partners

  1. TMC1 and TMC2 are components of the stereocilia mechanoelectrical transduction channel complex.

  2. The results suggest that a major component of channel adaptation is regulated by changes in intracellular Ca(2 (Montrer CA2 Kits ELISA)+).

  3. This study demonstrated that the M412K point mutation in TMC1 of Beethoven mice leads to a reduced Ca2 (Montrer CA2 Kits ELISA)+ permeability, more so in Tmc1Bth/Bth than in Tmc1Bh/+, and conductance of the MET channel of Mouse Outer Hair Cells.

  4. gene augmentation with Tmc1 or Tmc2 is well suited for further development as a strategy for restoration of auditory function in deaf patients who carry TMC1 mutations

  5. During the first postnatal week, we observed a normal mechanotransducer current in hair cells lacking Tmc1 or Tmc2; however, in the absence of both isoforms, we recorded a large MT current that was phase-shifted 180 degrees .

  6. This study demonstrate TMC1 is components of hair cell transduction channels and contribute to permeation properties.

  7. Tmc1 is expressed in mouse vestibular & cochlear hair cells near the stereocilia tips. Deletion of Tmc1 & Tmc2 causes deafness. Restoration of Tmc1 rescues mechanotransduction.

  8. Tmc1 was present within the endoplasmic reticulum as an integral membrane protein containing six transmembrane domains and cytosolic N- and C-termini.

TMC1 profil antigène

Antigen Summary

This gene is considered a member of a gene family predicted to encode transmembrane proteins. The specific function of this gene is unknown\; however, it is known to be required for normal function of cochlear hair cells. Mutations in this gene have been associated with progressive postlingual hearing loss and profound prelingual deafness.

Alternative names and synonyms associated with TMC1

  • transmembrane channel-like 1 (TMC1) Elisa Kit
  • transmembrane channel-like 1 (LOC100359097) Elisa Kit
  • transmembrane channel-like 1 (Tmc1) Elisa Kit
  • transmembrane channel-like gene family 1 (Tmc1) Elisa Kit
  • 4933416G09Rik Elisa Kit
  • Beethoven Elisa Kit
  • Bth Elisa Kit
  • CWEA1 Elisa Kit
  • DFNA36 Elisa Kit
  • DFNB7 Elisa Kit
  • DFNB11 Elisa Kit
  • dn Elisa Kit

Protein level used designations for TMC1

transmembrane channel-like protein 1 , transmembrane channel-like 1 , transmembrane channel-like protein 1-like , transmembrane cochlear-expressed protein 1 , transmembrane, cochlear expressed, 1 , transmembrane channel-like gene family 1 , deafness protein , transmembrane, cochlear expressed 1

GENE ID SPECIES
427255 Gallus gallus
472952 Pan troglodytes
484168 Canis lupus familiaris
538406 Bos taurus
704827 Macaca mulatta
100359097 Oryctolagus cuniculus
100445594 Pongo abelii
100516949 Sus scrofa
100581932 Nomascus leucogenys
117531 Homo sapiens
361739 Rattus norvegicus
13409 Mus musculus
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