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anti-Human EPAS1 Anticorps:
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Hamster Monoclonal EPAS1 Primary Antibody pour ChIP, ELISA - ABIN151063
Bernhardt, Wiesener, Weidemann, Schmitt, Weichert, Lechler, Campean, Ong, Willam, Gretz, Eckardt: Involvement of hypoxia-inducible transcription factors in polycystic kidney disease. dans The American journal of pathology 2007
Show all 146 Pubmed References
Fish Polyclonal EPAS1 Primary Antibody pour ChIP, ELISA - ABIN151051
Conrad, Freeman, Beitner-Johnson, Millhorn: EPAS1 trans-activation during hypoxia requires p42/p44 MAPK. dans The Journal of biological chemistry 1999
Show all 478 Pubmed References
Hamster Monoclonal EPAS1 Primary Antibody pour ELISA, IHC - ABIN250056
Harvey, Kind, Pantaleon, Armstrong, Thompson: Oxygen-regulated gene expression in bovine blastocysts. dans Biology of reproduction 2004
Show all 19 Pubmed References
Hamster Monoclonal EPAS1 Primary Antibody pour ELISA, ICC - ABIN250055
Mekhail, Gunaratnam, Bonicalzi, Lee: HIF activation by pH-dependent nucleolar sequestration of VHL. dans Nature cell biology 2004
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Fish Polyclonal EPAS1 Primary Antibody pour ELISA, ICC - ABIN249868
Alvarez-Tejado, Naranjo-Suarez, Jiménez, Carrera, Landázuri, del Peso: Hypoxia induces the activation of the phosphatidylinositol 3-kinase/Akt cell survival pathway in PC12 cells: protective role in apoptosis. dans The Journal of biological chemistry 2001
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Human Monoclonal EPAS1 Primary Antibody pour IHC (fro), IHC (p) - ABIN1742588
Wiesener, Turley, Allen, Willam, Eckardt, Talks, Wood, Gatter, Harris, Pugh, Ratcliffe, Maxwell: Induction of endothelial PAS domain protein-1 by hypoxia: characterization and comparison with hypoxia-inducible factor-1alpha. dans Blood 1998
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Human Monoclonal EPAS1 Primary Antibody pour IHC (p) - ABIN2473999
Pike, Phadwal, Simon, Harris: ATF4 orchestrates a program of BH3-only protein expression in severe hypoxia. dans Molecular biology reports 2012
Human Polyclonal EPAS1 Primary Antibody pour IF (p), IHC (p) - ABIN686662
Li, Chen, Shao, Tang, Chen, Chen, Xu: Oxidative stress induces the decline of brain EPO expression in aging rats. dans Experimental gerontology 2016
Human Monoclonal EPAS1 Primary Antibody pour AA, ELISA - ABIN863099
Kim, Perera, Zhou, Carretero, Yeh, Heathcote, Jackson, Nikolinakos, Ospina, Naumov, Brandstetter, Weigman, Zaghlul, Hayes, Padera, Heymach, Kung, Sharpless, Kaelin, Wong: HIF2alpha cooperates with RAS to promote lung tumorigenesis in mice. dans The Journal of clinical investigation 2009
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Hamster Monoclonal EPAS1 Primary Antibody pour ELISA, FACS - ABIN406865
Su, Li, Cui, Ji, Geng, Chai, Ma, Bai, Yang, Wuren, Ge, Rondina: The Local HIF-2α/EPO Pathway in the Bone Marrow is Associated with Excessive Erythrocytosis and the Increase in Bone Marrow Microvessel Density in Chronic Mountain Sickness. dans High altitude medicine & biology 2015
positive and bilateral HIF2-EGFR (Montrer EGFR Anticorps) regulatory crosstalk promotes antiestrogen resistance in estrogen receptor alpha (Montrer ESR1 Anticorps)-positive breast cancer
NAP peptide prevents outer blood retinal barrier breakdown by reducing HIF1alpha (Montrer HIF1A Anticorps)/HIF2alpha, VEGF (Montrer VEGFA Anticorps)/VEGFRs, and increasing HIF3alpha expression Moreover it is able to reduce the percentage of apoptotic cells by modulating the expression of two death related genes, BAX (Montrer BAX Anticorps) and Bcl2 (Montrer BCL2 Anticorps).
Data identify a previously unrecognized cellular process associated with hypoxia, and suggests that in vivo tumour hypoxia determines copper isotope fractionation in hepatocellular carcinoma and demonstrate that this effect of hypoxia is pH, HIF-1 (Montrer HIF1A Anticorps) and -2 independent.
findings suggest the HIF-2alpha pathway predominates over HIF-1alpha (Montrer HIF1A Anticorps) signalling in neuronal-like cells following acute hypoxia
these findings demonstrated that HIF-2alpha in vselMSCs cooperated with Oct4 (Montrer POU5F1 Anticorps) in survival and function. The identification of the cooperation between HIF-2alpha and Oct4 (Montrer POU5F1 Anticorps) will lead to deeper characterization of the downstream targets of this interaction in vselMSCs and will have novel pathophysiological implications for the repair of infarcted myocardium.
findings indicate that HIF-2alpha increases cancer cell growth by up-regulating YAP1 (Montrer YAP1 Anticorps) activity
Findings show that hypoxia inducible factor 1 alpha subunit (HIF-1alpha (Montrer HIF1A Anticorps)) is phylogenetically conserved among most metazoans, whereas HIF-2alpha protein appeared later.
proteomic experiments on Normoxic Neuroblastoma (Montrer ARHGEF16 Anticorps) cells to investigate HIF-2alpha downstream-regulated proteins or pathways
HIF1A (Montrer HIF1A Anticorps) and HIF2A contribute to cancer stem cells survival but play different roles -HIF1A (Montrer HIF1A Anticorps) being more responsible for survival functions and HIF2A for self-renewal [review].
The negative feedback modulation between LncRNA-SARCC/AR complex and HIF-2alpha signaling may then lead to differentially modulated RCC (Montrer XRCC1 Anticorps) progression in a VHL (Montrer VHL Anticorps)-dependent manner. Together, these results may provide us a new therapeutic approach via targeting this newly identified signal from LncRNA-SARCC to AR-mediated HIF-2alpha/C-MYC (Montrer MYC Anticorps) signals against RCC (Montrer XRCC1 Anticorps) progression.
Chronic activity of HIF2 in stromal progenitors impairs kidney development. Finally, these data confirm the concept that normal stroma function is essential for normal tubular differentiation.
this study shows that HIF-2alpha acts in resting macrophages as a phagocytosis suppressor implying an important relationship between the levels of HIF-2alpha and susceptibility to infection
in neurons HIF-1 (Montrer HIF1A Anticorps) and HIF-2 have redundant functions for cellular survival under ischemic conditions. By contrast, lack of anti-survival factors in Hif1a (Montrer HIF1A Anticorps)/Hif2a-deficient mice might protect from early acute neuronal cell death and neurological impairment, indicating a benefit of HIF-pathway inhibition in neurons in the very acute phase after ischemic stroke
HIF-2alpha is a novel regulator of neutrophil recruitment to colon tumors.
AQP1 (Montrer AQP1 Anticorps) deficiency delays long-term ischemia-reperfusion resolution, partly through repressing angiogenesis mediated by destabilizing HIF-2alpha.
HIF1alpha (Montrer HIF1A Anticorps) and HIF2alpha are dispensable for muscle stem cell function under normoxia but are required for maintaining satellite cell self-renewal in hypoxic environments.
eIF3e (Montrer EIF3E Anticorps) is an angiogenesis suppressor. Silencing of eIF3e (Montrer EIF3E Anticorps) promotes blood perfusion recovery after limb ischemia through stabilization of hypoxia-inducible factor 2alpha activity.
The regulatory connection between HIF-2alpha and VEGFR-1 (Montrer FLT1 Anticorps), VEGFR-2 (Montrer KDR Anticorps) and MMP2 (Montrer MMP2 Anticorps).
HIF2alpha is essential for the acute postprandial regulation of hepatic glucagon (Montrer GCG Anticorps) signaling.
immunostaining for HIF-1alpha (Montrer HIF1A Anticorps) and HIF-2alpha was observed during endochondral ossification; only HIF-2alpha was present at sites of intramembranous ossification
There was an association of an EPAS1 (HIF2alpha) double variant in the oxygen degradation domain of EPAS1 in Angus cattle with high altitude pulmonary hypertension (HAPH). There was upregulation of 26 of 27 HIF2alpha target genes in EPAS1 carriers with HAPH.
This gene encodes a transcription factor involved in the induction of genes regulated by oxygen, which is induced as oxygen levels fall. The encoded protein contains a basic-helix-loop-helix domain protein dimerization domain as well as a domain found in proteins in signal transduction pathways which respond to oxygen levels. Mutations in this gene are associated with erythrocytosis familial type 4.
endothelial PAS domain protein 1
, endothelial PAS domain-containing protein 1-like
, HIF-1-alpha-like factor
, HIF-1alpha-like factor
, PAS domain-containing protein 2
, basic-helix-loop-helix-PAS protein MOP2
, class E basic helix-loop-helix protein 73
, endothelial PAS domain-containing protein 1
, hypoxia-inducible factor 2 alpha
, hypoxia-inducible factor 2-alpha
, member of PAS protein 2
, HIF-related factor
, HIF1 alpha-like factor
, HIF1alpha-like factor
, HLF (HIF1alpha-like factor)
, Hif like protein
, hypoxia inducible transcription factor 2alpha
, HIF-2 alpha
, HIF2 alpha
, hypoxia inducible factor 2, alpha subunit
, hypoxia inducible factor 2a