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LZK cooperates with DLK (Montrer DAPK3 Kits ELISA) to promote retinal ganglion cell death in response to axon injury.
Chromosomal localization studies involving FISH mapping demonstrated that the human LZK gene is located at 3q27.
Scaffold protein (Montrer HOMER1 Kits ELISA) POSH (Montrer SH3RF1 Kits ELISA), in association with Shroom3 (Montrer SHROOM3 Kits ELISA) and mixed lineage kinase LZK, relays axon outgrowth inhibition downstream of NogoA (Montrer RTN4 Kits ELISA) and PirB (Montrer LILRB3 Kits ELISA) proteins.
The protein encoded by this gene is a member of serine/threonine protein kinase family. This kinase contains a dual leucine-zipper motif, and has been shown to form dimers/oligomers through its leucine-zipper motif. This kinase can phosphorylate and activate MAPK8/JNK, MAP2K7/MKK7, which suggests a role in the JNK signaling pathway.
leucine zipper-bearing kinase
, mitogen-activated protein kinase kinase kinase 13
, mitogen activated protein kinase kinase kinase 13 type A
, mitogen-activated protein kinase kinase kinase 13-A
, mixed lineage kinase
, mitogen activated protein kinase kinase kinase 13