Aperçu des produits pour anti-Patched 2 (PTCH2) Anticorps

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anti-Patched 2 Anticorps (PTCH2)
Chez www.anticorps-enligne.fr sont 29 Patched 2 (PTCH2) Anticorps de 13 de différents fournisseurs disponibles. De plus, nous expédions Patched 2 Protéines (10) et et beaucoup plus de produits pour cette protéine. Un total de 43 Patched 2 produits sont actuellement listés.
lep, patched-2, ptc-2, ptc1, PTC2, Ptch1, ptch2, xptc-2, xptch-2
afficher tous les anticorps Gène GeneID UniProt
PTCH2 366452  
PTCH2 8643 Q9Y6C5
PTCH2 19207 O35595

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anti-Rat (Rattus) Patched 2 Anticorps:

anti-Human Patched 2 Anticorps:

anti-Mouse (Murine) Patched 2 Anticorps:

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anti-Patched 2 Anticorps mieux référencés

  1. Cow (Bovine) Polyclonal Patched 2 Primary Antibody pour WB - ABIN2782247 : Gregory, Barlow, McLay, Kaul, Swarbreck, Dunham, Scott, Howe, Woodfine, Spencer, Jones, Gillson, Searle, Zhou, Kokocinski, McDonald, Evans, Phillips, Atkinson, Cooper, Jones, Hall, Andrews, Lloyd et al.: The DNA sequence and biological annotation of human chromosome 1. ... dans Nature 2006 (PubMed)

Plus d’anticorps contre Patched 2 partenaires d’interaction

Xenopus laevis Patched 2 (PTCH2) interaction partners

  1. Zyxin (Montrer ZYX Anticorps) binding to Ptc2 is due to the interaction of Zyxin (Montrer ZYX Anticorps) 2nd LIM (Montrer PDLIM5 Anticorps)-domain (530-590 aa) with the under-membrane region of the cytoplasmic C-terminus of Ptc2 (1159-1412 aa).

Zebrafish Patched 2 (PTCH2) interaction partners

  1. The Hedgehog (Montrer SHH Anticorps) co-receptors patched1 (Montrer PTCH1 Anticorps) and patched2 are expressed in regions of the perichondrium that will form bone before the onset of ossification.

  2. The generation and characterization of the ptc1 (Montrer PTCH1 Anticorps);ptc2 double mutant assigned novel and unexpected functions to the Hh signaling pathway.

Human Patched 2 (PTCH2) interaction partners

  1. Frameshift mutation in the PTCH2 gene can cause nevoid basal cell carcinoma syndrome.

  2. PTCH2 isoforms have distinct roles in Hedgehog (Montrer SHH Anticorps) signalling.

  3. PTCH2 (2157G-->A), a novel missense mutation, underlies NBCCS (Montrer PTCH1 Anticorps), resulting in the loss of PTCH2 inhibitory function in the Shh (Montrer SHH Anticorps) signalling pathway.

  4. A susceptibility locus on 1p32-1p34 for congenital macrostomia in a Chinese family and identification of a novel PTCH2 mutation are reported.

Mouse (Murine) Patched 2 (PTCH2) interaction partners

  1. Ptch2(-/-) niche cells show hyperactive noncanonical HH signaling, resulting in reduced production of essential HSC (Montrer FUT1 Anticorps) regulators (Scf (Montrer KITLG Anticorps), Cxcl12 (Montrer CXCL12 Anticorps), and Jag1 (Montrer JAG1 Anticorps)) and depletion of osteoblasts.

  2. Ptch2 is a functional Shh (Montrer SHH Anticorps) receptor that shares overlapping functions with Ptch1 (Montrer PTCH1 Anticorps) in Smo regulation and limb development.

  3. Ptch1 (Montrer PTCH1 Anticorps)(-/-);Ptch2(-/-) cells cannot further activate the Shh (Montrer SHH Anticorps) response, demonstrating that Ptch2 mediates the response to Shh (Montrer SHH Anticorps) in the absence of Ptch1 (Montrer PTCH1 Anticorps).

  4. Our studies indicate that concomitant loss of Ptch1 (Montrer PTCH1 Anticorps) and Ptch2 activity inhibits epidermal lineage specification and differentiation.

  5. PTCH2 is a direct transcriptional target that antagonizes hedgehog (Montrer SHH Anticorps) signaling in NIH/3T3 cells.

  6. Single-strand conformation polymorphism analysis was used to map mouse Ptch2 to chromosome 4 between the microsatellite markers D4Mit20 and D4Mit334.

  7. Functional compensation by Ptc1 (Montrer PTCH1 Anticorps) might account for the lack of a strong mutant phenotype in Ptc2-deficient mice. Normal Ptc2 function is required for adult skin homeostasis.

Patched 2 (PTCH2) profil antigène

Antigen Summary

This gene encodes a transmembrane receptor of the patched gene family. The encoded protein may function as a tumor suppressor in the hedgehog signaling pathway. Alterations in this gene have been associated with nevoid basal cell carcinoma syndrome, basal cell carcinoma, medulloblastoma, and susceptibility to congenital macrostomia. Alternatively spliced transcript variants have been described.

Alternative names and synonyms associated with Patched 2 (PTCH2)

  • patched homolog 2 (Drosophila) (Ptch2) anticorps
  • patched 2 (ptch2-b) anticorps
  • patched 2 (ptch2-a) anticorps
  • patched 1 (ptch1) anticorps
  • patched 2 (PTCH2) anticorps
  • patched homolog 2 (Ptch2) anticorps
  • lep anticorps
  • patched-2 anticorps
  • ptc-2 anticorps
  • ptc1 anticorps
  • PTC2 anticorps
  • Ptch1 anticorps
  • ptch2 anticorps
  • xptc-2 anticorps
  • xptch-2 anticorps

Protein level used designations for anti-Patched 2 (PTCH2) Anticorps

patched homolog 2 , patched homolog 1 , patched-2 , xptc 2 , leprechaun , patched 2 , protein patched homolog 1 , protein patched homolog 2

366452 Rattus norvegicus
397836 Xenopus laevis
100191013 Xenopus laevis
30189 Danio rerio
8643 Homo sapiens
482519 Canis lupus familiaris
507948 Bos taurus
19207 Mus musculus
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