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This study reveals that Drosophila ATF-2 (dATF-2) is required for heterochromatin assembly, whereas the stress-induced phosphorylation of dATF-2, via Mekk1 (Montrer MAP3K1 Kits ELISA)-p38 (Montrer MAPK14 Kits ELISA), disrupts heterochromatin.
ATF-2 is critical for regulation of fat metabolism.
dATF-2 is activated by the locomotor while it increases sleep, suggesting a role for dATF-2 as a regulator to connect sleep with locomotion.
this study demonstrates that CPEB2 (Montrer CPEB2 Kits ELISA) alternative splicing is a major regulator of key cellular pathways linked to anoikis resistance and metastasis.
there is a decrease in epidermal GDNF and GFRalpha-1 protein expression in normal human skin with ageing
Noxin (Montrer C11orf82 Kits ELISA) facilitated the expression of Cyclin D1 (Montrer CCND1 Kits ELISA) and Cyclin E1 (Montrer CCNE1 Kits ELISA) through activating P38 (Montrer CRK Kits ELISA)-activating transcription factor 2 signaling pathway, thus enhanced cell growth of breast cancer
In SOD1 (Montrer SOD1 Kits ELISA)(G93A) spinal cords, we verified a strict correlation in the expression of the TNFalpha (Montrer TNF Kits ELISA), TNFR1 (Montrer TNFRSF1A Kits ELISA) and GDNF triad at different stages of disease progression. Yet, ablation of TNFR1 (Montrer TNFRSF1A Kits ELISA) completely abolished GDNF rises in both SOD1 (Montrer SOD1 Kits ELISA)(G93A) astrocytes and spinal cords, a condition that accelerated motor neuron degeneration (Montrer CLN8 Kits ELISA) and disease progression
In functional dyspepsia patients, duodenal expression of GDNF protein was significantly increased compared with controls. GDNF was localized in enteric glial cells, eosinophils, and epithelial cells.
these observations suggest that CD99 (Montrer CD99 Kits ELISA) is involved in the regulation of CD1a (Montrer CD1A Kits ELISA) transcription and expression by increasing ATF-2.
Suppression of miR-383 may increase the therapeutic potential of human bone-marrow-derived MSCs in treating spinal cord injury via augmentation of GDNF protein levels.
This review provides an overview of the currently known upstream regulators and downstream targets of ATF2. [review]
TNF (Montrer TNF Kits ELISA) induces the binding of ATF2 to the TNF (Montrer TNF Kits ELISA)-responsive element.
Our results suggest that GDNF rs3096140 might be involved in the genetic background of smoking, independent of anxiety characteristics.
adiponectin (Montrer ADIPOQ Kits ELISA) inhibited endoplasmic reticulum stress and apoptosis of adipocyte in vivo and in vitro by activating the AMPK (Montrer PRKAA1 Kits ELISA)/PPARalpha (Montrer PPARA Kits ELISA)/ATF2 pathway.
Quantitative real-time polymerase chain reaction (qRT-PCR) and Western blotting were used to detect the mRNA and protein expressions of p-p38MAPK (Montrer MAPK14 Kits ELISA), AAT, signal transducer and activator of transcription 1 (STAT1 (Montrer STAT1 Kits ELISA)) and activating transcription factor2 (ATF2)
increased expression of the gene encoding PKCepsilon (Montrer PRKCE Kits ELISA) and abundance of phosphorylated, transcriptionally active ATF2 were observed in advanced-stage melanomas and correlated with decreased FUK (Montrer FUK Kits ELISA) expression
These data identified a role for ATF2 in regulating melanocyte responses.
suppression of tumorigenesis by JNK (Montrer MAPK8 Kits ELISA) requires ATF2.
Taken together, our observations indicated that SOCS2 (Montrer SOCS2 Kits ELISA) could suppress myotube formation, act as an anti-regulator of mitochondria biogenesis via inhibiting p38 MAPK (Montrer MAPK14 Kits ELISA) signal pathway.
ATF2 is an important transcriptional factor relating to inflammation through the suppression of ATF3 (Montrer ATF3 Kits ELISA) in M1 macrophages of White adipose tissue.
ATF-2 plays critical roles for proper expression of tyrosine hydroxylase (Montrer TH Kits ELISA) gene and for neurite extension of catecholaminergic neurons, possibly through repressor-like action.
these studies show that the IL-1beta (Montrer IL1B Kits ELISA)-induced increase in intestinal tight junction permeability was regulated by p38 (Montrer CRK Kits ELISA) kinase activation of ATF-2 and by ATF-2 regulation of MLCK (Montrer MYLK Kits ELISA) gene activity
The ATF2 represses renin (Montrer REN Kits ELISA) expression by drifting the transcriptional control of renin (Montrer REN Kits ELISA) gene away from CRE-binding protein (CREB (Montrer CREB1 Kits ELISA)).
ATF2-based luciferase reporter to monitor non-canonical Wnt (Montrer WNT2 Kits ELISA) signaling in Xenopus embryos.
The current data shows a timely GFP translation in bovine embryos depending on sequences in the 3'UTR (Montrer UTS2R Kits ELISA) of ATF1 (Montrer AFT1 Kits ELISA)/2, and indicates a difference between short and long isoforms.
Ang II (Montrer AGT Kits ELISA) increases endothelial arginase activity/expression through a p38 MAPK (Montrer MAPK14 Kits ELISA)/ATF-2 pathway leading to reduced endothelial NO production
Data indicate that Ser738/742-to-glutamate (Montrer GRIN2A Kits ELISA) protein kinase D (Montrer PRKD1 Kits ELISA) mutant increased AngII-induced CREB (Montrer CREB1 Kits ELISA) protein and activating transcription factor 2 phosphorylation, and phospho-CREB (Montrer CREB1 Kits ELISA) binding to the steroidogenic acute regulatory protein (Montrer STAR Kits ELISA) promoter.
This gene encodes a transcription factor that is a member of the leucine zipper family of DNA binding proteins. This protein binds to the cAMP-responsive element (CRE), an octameric palindrome. It forms a homodimer or a heterodimer with c-Jun and stimulates CRE-dependent transcription. This protein is also a histone acetyltransferase (HAT) that specifically acetylates histones H2B and H4 in vitro\; thus it may represent a class of sequence-specific factors that activate transcription by direct effects on chromatin components. Several alternatively spliced transcript variants have been found for this gene.
, activating transcription factor 2 splice variant ATF2-var2
, cAMP response element-binding protein CRE-BP1
, cAMP responsive element binding protein 2, formerly
, cAMP-dependent transcription factor ATF-2
, cAMP-responsive element-binding protein 2
, cyclic AMP-dependent transcription factor ATF-2
, cyclic AMP-responsive element-binding protein 2
, activating transcription factor-2, isoform A
, activating transcription factor-2, isoform C
, activating transcription factor-2, isoform B
, cyclic AMP response element binding protein 2
, chimerin (chimaerin) 1