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anti-Human JNK Anticorps:
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Cow (Bovine) Polyclonal JNK Primary Antibody pour IF (p), IHC (p) - ABIN732368
Rosenzweig, Djap, Ou, Quinn: Mechanical injury of bovine cartilage explants induces depth-dependent, transient changes in MAP kinase activity associated with apoptosis. dans Osteoarthritis and cartilage / OARS, Osteoarthritis Research Society 2012
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Human Monoclonal JNK Primary Antibody pour IP, WB - ABIN967330
Adler, Fuchs, Kim, Kraft, King, Pelling, Ronai: jun-NH2-terminal kinase activation mediated by UV-induced DNA lesions in melanoma and fibroblast cells. dans Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research 1996
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Human Monoclonal JNK Primary Antibody pour FACS, WB - ABIN968867
Fleming, Armstrong, Morrice, Paterson, Goedert, Cohen: Synergistic activation of stress-activated protein kinase 1/c-Jun N-terminal kinase (SAPK1/JNK) isoforms by mitogen-activated protein kinase kinase 4 (MKK4) and MKK7. dans The Biochemical journal 2001
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Human Monoclonal JNK Primary Antibody pour ICS - ABIN1177076
Huang, Shi, Chi: Regulation of JNK and p38 MAPK in the immune system: signal integration, propagation and termination. dans Cytokine 2009
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Human Monoclonal JNK Primary Antibody pour FACS, WB - ABIN968866
Kyriakis, Avruch: Mammalian mitogen-activated protein kinase signal transduction pathways activated by stress and inflammation. dans Physiological reviews 2001
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Human Monoclonal JNK Primary Antibody pour ICS - ABIN1177075
Wagner, Nebreda: Signal integration by JNK and p38 MAPK pathways in cancer development. dans Nature reviews. Cancer 2009
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Human Polyclonal JNK Primary Antibody pour WB - ABIN3043004
Zheng, Liu, Liu, Ma, Zhou, Chen, Chang, Wang, Yang, He: Cucurbitacin B inhibits growth and induces apoptosis through the JAK2/STAT3 and MAPK pathways in SH?SY5Y human neuroblastoma cells. dans Molecular medicine reports 2014
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Caenorhabditis elegans (C. elegans) Polyclonal JNK Primary Antibody pour IHC (p), IHC - ABIN151424
Oh, Mukhopadhyay, Svrzikapa, Jiang, Davis, Tissenbaum: JNK regulates lifespan in Caenorhabditis elegans by modulating nuclear translocation of forkhead transcription factor/DAF-16. dans Proceedings of the National Academy of Sciences of the United States of America 2005
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Human Polyclonal JNK Primary Antibody pour IHC, IHC (p) - ABIN4327961
Gao, Wang, Zhang, Yu, Ji, Wang, Zhang, Jiang, Jin, Huang, Zhang, Li: Tumor necrosis factor receptor-associated factor 5 (Traf5) acts as an essential negative regulator of hepatic steatosis. dans Journal of hepatology 2016
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Human Polyclonal JNK Primary Antibody pour IF, IHC (p) - ABIN391724
Deng, Ren, Yang, Lin, Wu: A JNK-dependent pathway is required for TNFalpha-induced apoptosis. dans Cell 2003
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Here we uncover a cell non-autonomous requirement for the Epidermal growth factor receptor (Egfr (Montrer EGFR Anticorps)) pathway in the lateral epidermis for sustained dpp (Montrer TGFb Anticorps) expression in the LE. Specifically, we demonstrate that Egfr (Montrer EGFR Anticorps) pathway activity in the lateral epidermis prevents expression of the gene scarface (scaf), encoding a secreted antagonist of JNK signaling
n addition to significantly increasing the number of JNK target genes identified so far, our results reveal that the LE is a highly heterogeneous morphogenetic organizer, sculpted through crosstalk between JNK, segmental and AP signalling. This fine-tuning regulatory mechanism is essential to coordinate morphogenesis and dynamics of tissue sealing
malignant transformation of the ras(V12)scrib(1 (Montrer SCRIB Anticorps)) tumors requires bZIP protein Fos, the ETS (Montrer ETS1 Anticorps)-domain factor Ets21c and the nuclear receptor Ftz-F1 (Montrer NR5A2 Anticorps), all acting downstream of Jun-N-terminal kinase.
Diminished MTORC1-dependent JNK activation underlies the neurodevelopmental defects associated with lysosomal dysfunction.
ROS (Montrer ROS1 Anticorps)/JNK/p38 (Montrer MAPK14 Anticorps)/Upd (Montrer UROD Anticorps) stress responsive module restores tissue homeostasis. This module is not only activated after cell death induction but also after physical damage and reveals one of the earliest responses for imaginal disc regeneration.
Significantly, the JNK pathway is responsible for the majority of the phenotypes and transcriptional changes downstream of Notch (Montrer NOTCH1 Anticorps)-Src (Montrer SRC Anticorps) synergy.
This study demonstrated that the mechanism by which Bsk (Montrer FRK Anticorps) is required for pruning is through reducing the membrane levels of the adhesion molecule (Montrer NCAM1 Anticorps) Fasciclin II (Montrer NCAM2 Anticorps) (FasII)
Study solves the crystal structure of unphosphorylated DJNK in complex with adenylyl imidodiphosphate (AMP (Montrer AMPH Anticorps)-PNP (Montrer NP Anticorps)) and magnesium.
PERK/ATF4 activated the JNK pathway through Rac1 and Slpr activation in apoptotic cells.
Data show that oxidative stress and neuroinflammation are intrinsic components of TDP-43 (Montrer TARDBP Anticorps)-associated neurodegeneration and the balance between cytoprotective JNK and cytotoxic p38 (Montrer MAPK14 Anticorps) signaling dictates phenotypic outcome to TDP-43 (Montrer TARDBP Anticorps) expression in Drosophila.
These results suggest that Bacteroides fragilis enterotoxin induced accumulation of autophagosomes in endothelial cells, but activation of a signaling pathway involving JNK, AP-1 (Montrer FOSB Anticorps), and CHOP (Montrer DDIT3 Anticorps) may interfere with complete autophagy.
The findings indicate that ERK (Montrer EPHB2 Anticorps) and JNK signaling pathways, as well as NF-kappaB (Montrer NFKB1 Anticorps)-mediated signaling are important contributors to the pathogenesis of Kashin-Beck disease.
The data suggested that JNK-enhanced Tudor-SN phosphorylation promotes the interaction between Tudor-SN and G3BP (Montrer G3BP1 Anticorps) and facilitates the efficient recruitment of Tudor-SN into stress granules under conditions of sodium arsenite-induced oxidative stress.
Taken together, our data demonstrate that JNK regulates triple-negative breast cancer (TNBC)tumorigenesis by promoting CSC phenotype through Notch1 (Montrer NOTCH1 Anticorps) signaling via activation of c-Jun (Montrer JUN Anticorps) and indicate that JNK/c-Jun/Notch1 (Montrer NOTCH1 Anticorps) signaling is a potential therapeutic target for TNBC
Here, the authors show that the CDK (Montrer CDK4 Anticorps) inhibitor p21 (CDKN1A (Montrer CDKN1A Anticorps)) maintains the viability of DNA damage-induced senescent cells. Upon p21 (Montrer CDKN1A Anticorps) knockdown, senescent cells acquired multiple DNA lesions that activated ataxia telangiectasia mutated (ATM (Montrer ATM Anticorps)) and nuclear factor (NF)-kappaB (Montrer NFKB1 Anticorps) kinase, leading to decreased cell survival. NF-kappaB (Montrer NFKB1 Anticorps) activation induced TNF-alpha (Montrer TNF Anticorps) secretion and JNK activation to mediate death of senescent cells in a...
Results indicate that cordycepin promotes caveolin-1 (CAV1 (Montrer CAV1 Anticorps))upregulation to enhance c-jun N-terminal kinase (JNK)/forkhead box O3A (Montrer FOXO3 Anticorps) protein (Foxo3a (Montrer FOXO3 Anticorps)) signaling pathway activation, inducing apoptosis in lung cancer cells.
The combination of 2-deoxyglucose (2-DG) and ABT-199 initiated cell death through the reduction of myeloid cell leukemia sequence 1 protein (Mcl-1 (Montrer MCL1 Anticorps)) expression and c-Jun N-terminal kinase 1 (JNK1) activation and subsequent Bcl-xL (Montrer BCL2L1 Anticorps) protein degradation.
identified the c-Jun N-terminal kinase 1 (JNK1) as the kinase involved in the phosphorylation of NEIL1 (Montrer NEIL1 Anticorps)
This study suggests that advanced glycation end products (AGEs) and activation of AGEs receptor could induce the proliferation of smooth muscle cells from Saphenous vein but not smooth muscle cells from internal thoracic arteryvia MAP kinase (Montrer MAPK1 Anticorps) pathway in diabetes mellitus.
The increase in c-Jun N-terminal kinase (c-Jun) and specificity protein 1 (SP1 (Montrer SP1 Anticorps)) expressions was positively correlated with transforming growth factor beta 1 (TGFbeta1 (Montrer TGFB1 Anticorps)) in both high glucose-treated renal mesangial cells (HRMCs) and diabetic kidneys.
JNK1-mediated NLRP3 (Montrer NLRP3 Anticorps) phosphorylation at S194 is a critical priming event and is essential for NLRP3 (Montrer NLRP3 Anticorps) inflammasome activation.
The purpose of this study was to investigate mechanisms that govern the regulation of Npnt (Montrer NPNT Anticorps) gene expression by IL-1beta (Montrer IL1B Anticorps) in osteoblasts.
Doxorubicin (Dox)-administration to cardiomyocytes increased the levels of reactive oxygen species (ROS (Montrer ROS1 Anticorps)) in a time-dependent manner that followed the activation of stress-induced proteins p53 (Montrer TP53 Anticorps), p38 (Montrer CRK Anticorps) and JNK MAPKs, culminating in an increase in autophagy and apoptosis markers.
IL-6 (Montrer IL6 Anticorps) likely up-regulates IRP1 (Montrer ACO1 Anticorps) and DMT1 (Montrer SLC11A2 Anticorps) expression and down-regulates FPN1 (Montrer SLC40A1 Anticorps) expression in BV2 (Montrer DNAH9 Anticorps) microglial cells through JNK signaling pathways
Study examined whether JNK is present at the presynaptic site and its activity after presynaptic NMDA receptors stimulation; found that JNK, via the JBD domain, acts as a physiological effector on T-SNARE (Montrer VTI1B Anticorps) proteins; data suggest that JNK-dependent phosphorylation of T-SNARE (Montrer VTI1B Anticorps) proteins may have an important functional role in synaptic plasticity.
JNK signaling, which is inversely correlated with WNT4 (Montrer WNT4 Anticorps), plays an important role in perinatal germline cyst breakdown and primordial follicle formation by regulating E-cadherin (Montrer CDH1 Anticorps) junctions between oocytes in mouse ovaries.
It was concluded that compounds targeting JNK1 activity in brain and adipose tissue, which do not accumulate in the skin, may be safer and most effective.
JNK1 activation suppresses antifungal immunity in mice. JNK1-deficient mice had a significantly higher survival rate than wild-type control mice in response to Candida albicans infection, and the expression of JNK1 in hematopoietic innate immune cells was critical for this effect.
activation of JNK in the endoplasmic reticulum stress response precedes activation of XBP1 (Montrer XBP1 Anticorps).
Data suggest that single muscle immobilization induces a shift of myosin heavy chain (MHC) isoforms composition toward a faster contractile phenotype and decreases the polymorphic profile of single fibres, and that activation of p38 and JNK could be a potential mechanism involved in these contractile phenotype modifications during muscle immobilization.
Hyperosmotic Shock Engages Two Positive Feedback Loops through Caspase-3 (Montrer CASP3 Anticorps)-dependent Proteolysis of JNK1-2 and Bid (Montrer BID Anticorps).
JNK signaling is required to establish microtubule stability and maintain tissue cohesion in the gut (Montrer GUSB Anticorps).
Data show that the death pathway is independent of ERK (Montrer MAPK1 Anticorps) but relies on activating Bad phosphorylation through the control of both kinases Cdk1 (Montrer CDK1 Anticorps) and JNK.
study reports MPK8 connects protein phosphorylation, Ca(2 (Montrer CA2 Anticorps))+ and ROS (Montrer ROS1 Anticorps) in wound-signaling pathway; suggests 2 major activation modes, Ca(2 (Montrer CA2 Anticorps))+/CaMs and MAP kinase (Montrer MAPK1 Anticorps) phosphorylation cascade, converge at MPK8 to monitor or maintain an essential part of ROS (Montrer ROS1 Anticorps) homeostasis
our data provide strong evidence that Jip3 in fact serves as an adapter protein linking these cargos to dynein
P38 (Montrer MAPK14 Anticorps) and JNK have opposing effects on persistence of in vivo leukocyte migration in zebrafish.
A dorsalization pathway that is exerted by Axin (Montrer AXIN1 Anticorps)/JNK signaling and its inhibitor Aida (Montrer AIDA Anticorps) during vertebrate embryogenesis, is defined.
JNK-Mmp13 (Montrer MMP13 Anticorps) signaling pathway plays an essential role in regulating the innate immune cell migration in response to severe injury in vivo
Our genetic study unravelled the underlying pathway where JNK-1 is acting independently of insulin (Montrer INS Anticorps)-IGF-1 (Montrer IGF1 Anticorps) signalling (IIS) pathway to modulate longevity. In support of in vivo results in silico docking study of UA with C. elegans JNK-1 ATP-binding site suggested promising binding affinity exhibiting binding energy of -8.11 kcalmol(-1). UA induced JNK-1 activation in wild-type animals underlie the importance of pharmacologi
JNK-1 directly interacts with and phosphorylates DAF-16. Moreover, in response to heat stress, JNK-1 promotes the translocation of DAF-16 into the nucleus.
The present study shows in Caenorhabditis elegans that ambient temperature (1-37 degrees C) specifically influences the activation (phosphorylation) of the MAP kinase JNK-1 as well as the nuclear translocation of DAF-16.
the stress response is controlled by a c-Jun N-terminal kinase (JNK)-like mitogen-activated protein kinase (Montrer MAPK1 Anticorps) (MAPK (Montrer MAPK1 Anticorps)) signaling pathway, which is regulated by MLK-1 (Montrer MAP3K9 Anticorps) MAPK (Montrer MAPK1 Anticorps) kinase kinase (MAPKKK), MEK-1 (Montrer MAP2K1 Anticorps) MAPK (Montrer MAPK1 Anticorps) kinase (MAPKK), and KGB-1 (Montrer KCNJ3 Anticorps) JNK-like MAPK (Montrer MAPK1 Anticorps).
The protein encoded by this gene is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. This kinase is activated by various cell stimuli, and targets specific transcription factors, and thus mediates immediate-early gene expression in response to cell stimuli. The activation of this kinase by tumor-necrosis factor alpha (TNF-alpha) is found to be required for TNF-alpha induced apoptosis. This kinase is also involved in UV radiation induced apoptosis, which is thought to be related to cytochrom c-mediated cell death pathway. Studies of the mouse counterpart of this gene suggested that this kinase play a key role in T cell proliferation, apoptosis and differentiation. Four alternatively spliced transcript variants encoding distinct isoforms have been reported.
, JUN kinase
, Jun N-terminal kinase
, Jun NH2-terminal kinase
, Jun-N-terminal kinase
, c-Jun N-terminal kinase
, c-Jun aminoterminal kinase
, c-Jun-N-terminal kinase
, drosophila JNK
, JUN N-terminal kinase
, MAP kinase 8
, c-Jun N-terminal kinase 1
, mitogen-activated protein kinase 8 isoform JNK1 alpha1
, mitogen-activated protein kinase 8 isoform JNK1 beta2
, stress-activated protein kinase 1
, stress-activated protein kinase 1c
, JNK1 beta1 protein kinase
, MAPK 8
, mitogen activated protein kinase 8
, protein kinase mitogen-activated 8
, stress-activated protein kinase JNK1
, SAPK gamma
, c-jun NH2-terminal kinase
, p54 gamma
, mitogen-activated protein kinase 8