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Noguchi, Naziruddin, Shimoda, Fujita, Chujo, Takita, Peng, Sugimoto, Itoh, Tamura, Olsen, Kobayashi, Onaca, Levy, Matsumoto: Comparison of fresh and cultured islets from human and porcine pancreata. dans Transplantation proceedings 2010
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Human JNK Kit ELISA pour Cell ELISA - ABIN1981833
Hinton, Henderson, Blanks, Rudnicka, Miller: Monoclonal antibodies react with neuronal subpopulations in the human nervous system. dans The Journal of comparative neurology 1988
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Shintani, Hollingsworth, Wheelock, Johnson: Collagen I promotes metastasis in pancreatic cancer by activating c-Jun NH(2)-terminal kinase 1 and up-regulating N-cadherin expression. dans Cancer research 2006
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aken together, these results reveal that inactivation of Rpd3 (Montrer HDAC1 Kits ELISA) independently regulates JNK and Yki (Montrer YAP1 Kits ELISA) activities and that both Hippo and JNK signaling pathways contribute to Rpd3 (Montrer HDAC1 Kits ELISA) RNAi-induced apoptosis.
Data show that JNK signalling inhibits the growth of losers, while JAK (Montrer JAK3 Kits ELISA)/STAT (Montrer STAT1 Kits ELISA) signalling promotes competition-induced winner cell proliferation.
Here we uncover a cell non-autonomous requirement for the Epidermal growth factor receptor (Egfr (Montrer EGFR Kits ELISA)) pathway in the lateral epidermis for sustained dpp (Montrer TGFb Kits ELISA) expression in the LE. Specifically, we demonstrate that Egfr (Montrer EGFR Kits ELISA) pathway activity in the lateral epidermis prevents expression of the gene scarface (scaf), encoding a secreted antagonist of JNK signaling
n addition to significantly increasing the number of JNK target genes identified so far, our results reveal that the LE is a highly heterogeneous morphogenetic organizer, sculpted through crosstalk between JNK, segmental and AP signalling. This fine-tuning regulatory mechanism is essential to coordinate morphogenesis and dynamics of tissue sealing
malignant transformation of the ras(V12)scrib(1 (Montrer SCRIB Kits ELISA)) tumors requires bZIP protein Fos, the ETS (Montrer ETS1 Kits ELISA)-domain factor Ets21c and the nuclear receptor Ftz-F1 (Montrer NR5A2 Kits ELISA), all acting downstream of Jun-N-terminal kinase.
Diminished MTORC1-dependent JNK activation underlies the neurodevelopmental defects associated with lysosomal dysfunction.
ROS (Montrer ROS1 Kits ELISA)/JNK/p38 (Montrer MAPK14 Kits ELISA)/Upd (Montrer UROD Kits ELISA) stress responsive module restores tissue homeostasis. This module is not only activated after cell death induction but also after physical damage and reveals one of the earliest responses for imaginal disc regeneration.
Significantly, the JNK pathway is responsible for the majority of the phenotypes and transcriptional changes downstream of Notch (Montrer NOTCH1 Kits ELISA)-Src (Montrer SRC Kits ELISA) synergy.
This study demonstrated that the mechanism by which Bsk (Montrer FRK Kits ELISA) is required for pruning is through reducing the membrane levels of the adhesion molecule (Montrer NCAM1 Kits ELISA) Fasciclin II (Montrer NCAM2 Kits ELISA) (FasII)
Study solves the crystal structure of unphosphorylated DJNK in complex with adenylyl imidodiphosphate (AMP (Montrer AMPH Kits ELISA)-PNP (Montrer NP Kits ELISA)) and magnesium.
ERK1 (Montrer MAPK3 Kits ELISA) Directly Interacts With JNK1 Leading to Regulation of JNK1/c-Jun (Montrer JUN Kits ELISA) Activity and Cell Transformation.
TGM2 (Montrer TGM2 Kits ELISA) is involved in amyloid-beta (1-42)-induced pro-inflammatory activation via AP1 (Montrer FOSB Kits ELISA)/JNK signaling pathways in cultured monocytes.
NleL-induced JNK ubiquitylation, particularly mono-ubiquitylation at the Lys (Montrer LYZ Kits ELISA) 68 residue of JNK, impairs JNK's interaction with an upstream kinase MKK7 (Montrer MAP2K7 Kits ELISA), thus disrupting JNK phosphorylation and activation.
The surface immune molecule CD274 (Montrer CD274 Kits ELISA) plays a critical role in the proliferation of leukemia-initiating cells, LICs. The CD274 (Montrer CD274 Kits ELISA)/JNK/Cyclin D2 (Montrer CCND2 Kits ELISA) pathway promotes the cell cycle entry of LIC.
These data implicate HTRA1 (Montrer HTRA1 Kits ELISA) as a negative regulator of mesenchymal stem cell adipogenesis.
Our findings indicate that GADD45 (Montrer GADD45A Kits ELISA) essentially suppresses the MKK7 (Montrer MAP2K7 Kits ELISA)-JNK pathway and suggest that differentially expressed GADD45 (Montrer GADD45A Kits ELISA) family members fine-tune stress-inducible JNK activity.
Quantitative phosphoproteomic analysis identifies the critical role of JNK1 in neuroinflammation induced by Japanese encephalitis virus
post-translational modification facilitates the mobilization of SIRT6 (Montrer SIRT6 Kits ELISA) to DNA damage sites and is required for efficient recruitment of poly (ADP-ribose) polymerase 1 (PARP1 (Montrer PARP1 Kits ELISA)) to DNA break sites and for efficient repair of double-strand break.
PRDM5 (Montrer PRDM5 Kits ELISA) promotes the proliferation and invasion of murine melanoma cells through up-regulating JNK expression and strategies targeting PRDM5 (Montrer PRDM5 Kits ELISA) may be promising for the therapy of melanoma.
This study showed that the induction level of IL-32 (Montrer IL32 Kits ELISA) was increased in chronic rhinosinusitis with nasal polyps compared to normal nasal mucosa and that LPS (Montrer IRF6 Kits ELISA)-induced IL-32 (Montrer IL32 Kits ELISA) expression in nasal polyp-derived fibroblasts was regulated via the TLR4 (Montrer TLR4 Kits ELISA)/JNK/AKT (Montrer AKT1 Kits ELISA)/CREB (Montrer CREB1 Kits ELISA) signaling pathway.
transgenic mice overexpressing sPLA2 -IIA (Montrer PLA2G2A Kits ELISA) keratinocytes showed enhanced activation of EGFR (Montrer EGFR Kits ELISA) and JNK1/2 that led to c-Jun (Montrer JUN Kits ELISA) activation.
p53 (Montrer TP53 Kits ELISA) plays a novel protective role in APAP induced liver injury through inhibiting the activation of JNK, a key mediator in APAP-induced oxidative stress.
We crossed Ptf1a (Montrer PTF1A Kits ELISA)(Cre/+) ;Kras(G12D/+) mice with JNK1(-/-) mice to generate Ptf1a (Montrer PTF1A Kits ELISA)(Cre/+) ;Kras(G12D/+) ;JNK1(-/-) (Kras;JNK1(-/-) ) mice. Tumor weight was significantly lower in Kras;JNK1(-/-) mice than in Kras;JNK1(+/-) mice, whereas histopathological features were similar.we concluded that inhibition of activated JNK in pancreatic tumor stroma could be a potential therapeutic target to increase Ccl20 (Montrer CCL20 Kits ELISA) secretion
BOC (Montrer BOC Kits ELISA) interacts with ABL (Montrer ABL1 Kits ELISA) and activates JNK thereby promoting neuronal differentiation and neurite outgrowth.
The authors have found that JNK signaling is required for proper vascular morphogenesis and the normal formation of collateral arteries in muscle.
JNK1-mediated NLRP3 (Montrer NLRP3 Kits ELISA) phosphorylation at S194 is a critical priming event and is essential for NLRP3 (Montrer NLRP3 Kits ELISA) inflammasome activation.
The purpose of this study was to investigate mechanisms that govern the regulation of Npnt (Montrer NPNT Kits ELISA) gene expression by IL-1beta (Montrer IL1B Kits ELISA) in osteoblasts.
Doxorubicin (Dox)-administration to cardiomyocytes increased the levels of reactive oxygen species (ROS (Montrer ROS1 Kits ELISA)) in a time-dependent manner that followed the activation of stress-induced proteins p53 (Montrer TP53 Kits ELISA), p38 (Montrer CRK Kits ELISA) and JNK MAPKs, culminating in an increase in autophagy and apoptosis markers.
The results of this study suggest that JNK has a role in the disassembly adherens junctions by means of endocytosis that is required during buccopharyngeal membrane perforation.
Hyperosmotic Shock Engages Two Positive Feedback Loops through Caspase-3 (Montrer CASP3 Kits ELISA)-dependent Proteolysis of JNK1-2 and Bid (Montrer BID Kits ELISA).
JNK signaling is required to establish microtubule stability and maintain tissue cohesion in the gut (Montrer GUSB Kits ELISA).
Data show that the death pathway is independent of ERK (Montrer MAPK1 Kits ELISA) but relies on activating Bad phosphorylation through the control of both kinases Cdk1 (Montrer CDK1 Kits ELISA) and JNK.
study reports MPK8 connects protein phosphorylation, Ca(2 (Montrer CA2 Kits ELISA))+ and ROS (Montrer ROS1 Kits ELISA) in wound-signaling pathway; suggests 2 major activation modes, Ca(2 (Montrer CA2 Kits ELISA))+/CaMs and MAP kinase (Montrer MAPK1 Kits ELISA) phosphorylation cascade, converge at MPK8 to monitor or maintain an essential part of ROS (Montrer ROS1 Kits ELISA) homeostasis
our data provide strong evidence that Jip3 in fact serves as an adapter protein linking these cargos to dynein
P38 (Montrer MAPK14 Kits ELISA) and JNK have opposing effects on persistence of in vivo leukocyte migration in zebrafish.
A dorsalization pathway that is exerted by Axin (Montrer AXIN1 Kits ELISA)/JNK signaling and its inhibitor Aida (Montrer AIDA Kits ELISA) during vertebrate embryogenesis, is defined.
JNK-Mmp13 (Montrer MMP13 Kits ELISA) signaling pathway plays an essential role in regulating the innate immune cell migration in response to severe injury in vivo
Our genetic study unravelled the underlying pathway where JNK-1 is acting independently of insulin (Montrer INS Kits ELISA)-IGF-1 (Montrer IGF1 Kits ELISA) signalling (IIS) pathway to modulate longevity. In support of in vivo results in silico docking study of UA with C. elegans JNK-1 ATP-binding site suggested promising binding affinity exhibiting binding energy of -8.11 kcalmol(-1). UA induced JNK-1 activation in wild-type animals underlie the importance of pharmacologi
JNK-1 directly interacts with and phosphorylates DAF-16. Moreover, in response to heat stress, JNK-1 promotes the translocation of DAF-16 into the nucleus.
The present study shows in Caenorhabditis elegans that ambient temperature (1-37 degrees C) specifically influences the activation (phosphorylation) of the MAP kinase JNK-1 as well as the nuclear translocation of DAF-16.
the stress response is controlled by a c-Jun N-terminal kinase (JNK)-like mitogen-activated protein kinase (Montrer MAPK1 Kits ELISA) (MAPK (Montrer MAPK1 Kits ELISA)) signaling pathway, which is regulated by MLK-1 MAPK (Montrer MAPK1 Kits ELISA) kinase kinase (MAPKKK), MEK-1 (Montrer MAP2K1 Kits ELISA) MAPK (Montrer MAPK1 Kits ELISA) kinase (MAPKK), and KGB-1 (Montrer KCNJ3 Kits ELISA) JNK-like MAPK (Montrer MAPK1 Kits ELISA).
The protein encoded by this gene is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. This kinase is activated by various cell stimuli, and targets specific transcription factors, and thus mediates immediate-early gene expression in response to cell stimuli. The activation of this kinase by tumor-necrosis factor alpha (TNF-alpha) is found to be required for TNF-alpha induced apoptosis. This kinase is also involved in UV radiation induced apoptosis, which is thought to be related to cytochrom c-mediated cell death pathway. Studies of the mouse counterpart of this gene suggested that this kinase play a key role in T cell proliferation, apoptosis and differentiation. Four alternatively spliced transcript variants encoding distinct isoforms have been reported.
, JUN kinase
, Jun N-terminal kinase
, Jun NH2-terminal kinase
, Jun-N-terminal kinase
, c-Jun N-terminal kinase
, c-Jun aminoterminal kinase
, c-Jun-N-terminal kinase
, drosophila JNK
, JUN N-terminal kinase
, MAP kinase 8
, c-Jun N-terminal kinase 1
, mitogen-activated protein kinase 8 isoform JNK1 alpha1
, mitogen-activated protein kinase 8 isoform JNK1 beta2
, stress-activated protein kinase 1
, stress-activated protein kinase 1c
, JNK1 beta1 protein kinase
, MAPK 8
, mitogen activated protein kinase 8
, protein kinase mitogen-activated 8
, stress-activated protein kinase JNK1
, SAPK gamma
, c-jun NH2-terminal kinase
, p54 gamma
, mitogen-activated protein kinase 8