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Data indicate that mitogen-activated protein kinase kinase 6 (MKK6) levels were substantially higher in monocytes than in neutrophils.
Data show significant increase in the expression of MKK6 in Esophageal, Stomach, and Colon cancers as compared to controls.
uncover a new mechanism of deactivation of MKK6-p38 (Montrer CRK Kits ELISA) and substantiate a novel regulatory role of FBXO31 (Montrer FBXO5 Kits ELISA) in stress response
Serine phosphorylation of p66shc (Montrer SHC1 Kits ELISA) is carried out by active MKK6. beta-Amyloid-induced ROS (Montrer ROS1 Kits ELISA) production and apoptosis increased in the presence of MKK6 and p66shc (Montrer SHC1 Kits ELISA), which directly associate.
The models confirmed the reaction order, revealed processivity in the phosphorylation of MEK6 by ASK1 (Montrer MAP3K5 Kits ELISA), and suggested that the order of phosphorylation is dictated by both binding and catalysis rates.
crystal structure of human non-phosphorylated MAP2K6 (npMAP2K6) complexed with an ATP analogue was determined at 2.6 A resolution and represents an auto-inhibition state of MAP2K6
Data suggest aberrant MAP2K protein (MKK3 (Montrer MAP2K3 Kits ELISA), MKK4 (Montrer MAP2K4 Kits ELISA), MKK6, and MKK7 (Montrer MAP2K7 Kits ELISA)) expression indicates that altered cellular signal transduction mediated via JNK (Montrer MAPK8 Kits ELISA) and p38 (Montrer CRK Kits ELISA) may be common in bladder cancer.
the balance between MKK6 and MKK3 (Montrer MAP2K3 Kits ELISA) mediates p38 MAPK (Montrer MAPK14 Kits ELISA) associated resistance to cisplatin in NSCLC
activation by mechanical stretch induces HMGB1 (Montrer HMGB1 Kits ELISA) and cytokine expression in A549 cells
Results suggest that the p38alpha (Montrer MAPK14 Kits ELISA), MAPK (Montrer MAPK1 Kits ELISA), and MKK6 play prominent roles in IL-1beta (Montrer IL1B Kits ELISA) and C/EBP-beta (Montrer CEBPB Kits ELISA)-mediated C3 gene expression in astrocytes.
MKK3 (Montrer MAP2K3 Kits ELISA) and MKK6 differentially regulate bone loss due to estrogen withdrawal. MKK3 (Montrer MAP2K3 Kits ELISA) directly mediates osteoclastogenesis while MKK6 likely contributes to pro-inflammatory cytokine production that promotes osteoclast formation.
Activation of distinct p38MAPK (Montrer MAPK14 Kits ELISA) isoforms is regulated by the selective and synchronized action of two kinases, MKK3 (Montrer MAP2K3 Kits ELISA) and MKK6, in response to cell stress.
MKK6 is downreglated in peripheral CD4 (Montrer CD4 Kits ELISA)(+)T cells
p38alpha (Montrer MAPK14 Kits ELISA) can negatively regulate the stability of the MKK6 mRNA and thus control the steady-state concentration of one of its upstream activators
Involvement of MKK6 in apoptotic cell death in thymocytes.
MKK6 is one of three different protein kinases which activate p38 MAPK (Montrer MAPK14 Kits ELISA) in vitro.
MKK3 (Montrer MAP2K3 Kits ELISA) and MKK6 are rapidly activated during engagement of the Type I IFN receptor and play important roles in Type I IFN signaling and the generation of IFN responses
increased activity of Sox9 (Montrer SOX9 Kits ELISA) accounts at least in part for the phenotype caused by constitutive activation of MKK6 in chondrocytes
These results indicate that TAK1 (Montrer NR2C2 Kits ELISA) and MKK6 constitute the p38 (Montrer CRK Kits ELISA) signalling pathway to participate to Oc differentiation by RANKL (Montrer TNFSF11 Kits ELISA) through p65 (Montrer NFkBP65 Kits ELISA) phosphorylation and NFATc1 (Montrer NFATC1 Kits ELISA) induction.
All these results suggest that DGK (Montrer DGUOK Kits ELISA) may play a role in glucose transport in the skeletal muscle cells through modulating a MKK3 (Montrer MAP2K3 Kits ELISA)/6-p38 (Montrer CRK Kits ELISA) signaling pathway.
Arabidopsis MPK4 (Montrer MAPK4 Kits ELISA) can interact with and be phosphorylated by the cytokinesis-related MAP kinase (Montrer MAPK1 Kits ELISA) kinase, AtMKK6.
AtMKK6-AtMPK13 (Montrer MAPK1/3 Kits ELISA) module positively regulates lateral root formation.
Plants with mutations in the MKK6/ANQ gene exhibit severe defects in cytokinesis.
This gene encodes a member of the dual specificity protein kinase family, which functions as a mitogen-activated protein (MAP) kinase kinase. MAP kinases, also known as extracellular signal-regulated kinases (ERKs), act as an integration point for multiple biochemical signals. This protein phosphorylates and activates p38 MAP kinase in response to inflammatory cytokines or environmental stress. As an essential component of p38 MAP kinase mediated signal transduction pathway, this gene is involved in many cellular processes such as stress induced cell cycle arrest, transcription activation and apoptosis.
MAPK/ERK kinase 6
, MAPKK 6
, MEK 6
, SAPK kinase 3
, dual specificity mitogen-activated protein kinase kinase 6
, protein kinase, mitogen-activated, kinase 6 (MAP kinase kinase 6)
, stress-activated protein kinase kinase 3
, MAP kinase kinase 6
, mitogen activated protein kinase kinase 6
, protein kinase, mitogen activated, kinase 6
, mitogen-activated protein kinase kinase 3