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IL-21 (Montrer IL17C Kits ELISA) expression is promoted by MEKK4 in malignant T cells and is associated with progression risk in cutaneous T-cell lymphoma
Mutations in genes such as AKT2 (Montrer AKT2 Kits ELISA), CCNA1 (Montrer CCNA1 Kits ELISA), MAP3K4, and TGFBR1 (Montrer TGFBR1 Kits ELISA), were associated significantly with Epstein-Barr-positive gastric tumors, compared with EBV-negative tumors.
Map3k4 haploinsufficiency is the cause of T-associated sex reversal.
MTK1 was identified in the HER2 (Montrer ERBB2 Kits ELISA)/HER3 (Montrer ERBB3 Kits ELISA)-HRG (Montrer NRG1 Kits ELISA) mediated extracellular acidification and cell migration pathway in breast cancer cells.
MAP3K4 is sufficiently mediate the TGFbeta (Montrer TGFB1 Kits ELISA)-induced phosphorylation of p38 MAPK (Montrer MAPK14 Kits ELISA) in MEFs and HaCaT cells.
we have identified a reduced IL-1A (Montrer IL1A Kits ELISA) response, related to a low MAP3K4 expression and high expression of its inhibitor GSK3beta (Montrer GSK3b Kits ELISA), identifying a novel key player in Crohn's disease.
For the first time we report a significant association between nicotine dependence and DRD5 (Montrer DRD5 Kits ELISA), NPY1R (Montrer NPY1R Kits ELISA) MAP3K4 single nucleotide polymorphism.
The upstream molecule of the TRAIL-induced MAPK (Montrer MAPK1 Kits ELISA) activation is MEKK (Montrer MAP3K1 Kits ELISA), as opposed to ASK1 (Montrer MAP3K5 Kits ELISA), via the mediation of its signal through JNK (Montrer MAPK8 Kits ELISA)/p38 (Montrer CRK Kits ELISA) in a caspase-8 (Montrer CASP8 Kits ELISA)-dependent manner.
CIN85 (Montrer SH3KBP1 Kits ELISA) binding to a C-terminal motif within hTTP leads to the increased phosphorylation of hTTP, possibly through enhanced association with MEKK4
Axin (Montrer AXIN1 Kits ELISA) utilizes distinct regions for competitive MEKK1 (Montrer MAP3K1 Kits ELISA) and MEKK4 binding and JNK (Montrer MAPK8 Kits ELISA) activation.
by forming a complex with MEKK4 in skeletal muscle fibers, Gadd45a (Montrer GADD45A Kits ELISA) increases MEKK4 protein kinase (Montrer CDK7 Kits ELISA) activity, which is both sufficient to induce skeletal muscle fiber atrophy and required for Gadd45a (Montrer GADD45A Kits ELISA)-mediated skeletal muscle fiber atrophy.
suggest a requirement for GADD45gamma (Montrer GADD45G Kits ELISA) in promoting MAP3K4-mediated activation of p38 MAPK (Montrer MAPK14 Kits ELISA) signaling in embryonic gonadal somatic cells for testis determination
MTK1 plays an important role in the regulation of cell death and is also involved in the pathogenesis of heart failure.
During Th1 (Montrer HAND1 Kits ELISA) differentiation, the GADD45beta (Montrer GADD45B Kits ELISA)/GADD45gamma (Montrer GADD45G Kits ELISA)/MEKK4 pathway integrates upstream signals transduced by both T cell receptor and IL12 (Montrer IL12A Kits ELISA)/STAT4 (Montrer STAT4 Kits ELISA), leading to augmented interferon-gamma (Montrer IFNG Kits ELISA) production in a process independent of STAT4 (Montrer STAT4 Kits ELISA).
MEKK4 plays a critical role in regulating MKK4 (Montrer MAP2K4 Kits ELISA) activity and apoptotic cell death during neural tube development.
MEKK4 is the MAPK (Montrer MAPK1 Kits ELISA) kinase kinase for TRAF4 (Montrer TRAF4 Kits ELISA) regulation of the JNK (Montrer MAPK8 Kits ELISA) pathway
Hindbrains of exencephalic MEKK4(K1361R) embryos show a striking increase in neuroepithelial cell apoptosis and a dramatic loss of phosphorylation of MKK3 (Montrer MAP2K3 Kits ELISA) and -6, mitogen-activated protein kinase (Montrer MAPK1 Kits ELISA) kinases (MKKs (Montrer MKKS Kits ELISA)) regulated by MEKK4 in the p38 (Montrer CRK Kits ELISA) pathway.
MEKK4 regulates epithelial-to-mesenchymal transition in the endocardial cushions of the developing heart.
our results demonstrate a link between MEKK4 and filamin-a (Montrer FLNA Kits ELISA) that impacts neuronal migration initiation
The central core of each mitogen-activated protein kinase (MAPK) pathway is a conserved cascade of 3 protein kinases: an activated MAPK kinase kinase (MAPKKK) phosphorylates and activates a specific MAPK kinase (MAPKK), which then activates a specific MAPK. While the ERK MAPKs are activated by mitogenic stimulation, the CSBP2 and JNK MAPKs are activated by environmental stresses such as osmotic shock, UV irradiation, wound stress, and inflammatory factors. This gene encodes a MAPKKK, the MEKK4 protein, also called MTK1. This protein contains a protein kinase catalytic domain at the C terminus. The N-terminal nonkinase domain may contain a regulatory domain. Expression of MEKK4 in mammalian cells activated the CSBP2 and JNK MAPK pathways, but not the ERK pathway. In vitro kinase studies indicated that recombinant MEKK4 can specifically phosphorylate and activate PRKMK6 and SERK1, MAPKKs that activate CSBP2 and JNK, respectively but cannot phosphorylate PRKMK1, an MAPKK that activates ERKs. MEKK4 is a major mediator of environmental stresses that activate the CSBP2 MAPK pathway, and a minor mediator of the JNK pathway. Two alternatively spliced transcripts encoding distinct isoforms have been described.
mitogen-activated protein kinase kinase kinase 4
, MAP three kinase 1
, MAP/ERK kinase kinase 4
, MAPK/ERK kinase kinase 4
, MEK kinase 4
, MEKK 4
, SSK2/SSK22 MAP kinase kinase kinase, yeast, homolog of
, dJ473J16.1 (mitogen-activated protein kinase kinase kinase 4)
, predicted protein of HQ0412
, T-associated sex reversal
, mitogen activated protein kinase kinase kinase 4