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anti-Human MAPK11 Anticorps:
anti-Mouse (Murine) MAPK11 Anticorps:
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Human Polyclonal MAPK11 Primary Antibody pour IHC - ABIN966523
Jiang, Chen, Li, Guo, Gegner, Lin, Han: Characterization of the structure and function of a new mitogen-activated protein kinase (p38beta). dans The Journal of biological chemistry 1996
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Human Polyclonal MAPK11 Primary Antibody pour IHC - ABIN966524
Kumar, McDonnell, Gum, Hand, Lee, Young: Novel homologues of CSBP/p38 MAP kinase: activation, substrate specificity and sensitivity to inhibition by pyridinyl imidazoles. dans Biochemical and biophysical research communications 1997
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Human Monoclonal MAPK11 Primary Antibody pour ELISA, WB - ABIN969276
Beardmore, Hinton, Eftychi, Apostolaki, Armaka, Darragh, McIlrath, Carr, Armit, Clacher, Malone, Kollias, Arthur: Generation and characterization of p38beta (MAPK11) gene-targeted mice. dans Molecular and cellular biology 2005
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Results provide evidence that p38beta is an unusual enzyme that automodulates its basal, MAPKK-independent activity by several autophosphorylation events, which enhance and suppress its catalytic activity.
p38beta was significantly higher in esophageal squamous cell carcinoma tissues compared with paired normal controls. p38beta expression was observed to be significantly associated with overall prognosis.
Suggest that R-Ras regulates angiogenic activities of endothelial cells in part via inhibition of the p38MAPK-HSP27 axis of VEGF signaling.
These findings suggest that coronin 1A (Montrer CORO1A Anticorps) modulates endothelial cell apoptosis by regulating p38beta expression and activation.
The MAPK11 gene was variably methylated in monozygotic twins discordant for depressive disorder.
p38beta is a novel regulatory target of the transcription factor Pokemon (Montrer ZBTB7A Anticorps) and positively regulated by Pokemon (Montrer ZBTB7A Anticorps) in hepatic cells.
Data show that the p38 MAPK (p38 (Montrer MAPK14 Anticorps)) isoform (p38beta) mitogen-activated protein kinase 11 (MAPK11) is expressed in breast cancer cell.
Differential roles for p38alpha (Montrer MAPK14 Anticorps) and p38beta in the HGF (Montrer HGF Anticorps)-induced expression of key osteogenic markers.
study identified the structural motif responsible for the unique autophosphorylation capability of p38beta and the motif inhibiting this activity in living cells
Study identifies Hsp27 (Montrer HSPB1 Anticorps) as a novel target of ILK (Montrer ILK Anticorps)-p38beta signaling complexes, playing a key role in bladder cancer cell migration.
propose that active p38-Mapk14 (Montrer MAPK14 Anticorps)/11 act as enablers, and Erk1/2 (Montrer MAPK1/3 Anticorps) as drivers, of primitive endoderm differentiation during inner cell mass lineage specification and segregation.
Double deficiency of p38alpha (Montrer MAPK14 Anticorps) and p38beta in naive CD4 (Montrer CD4 Anticorps)(+) T cells resulted in an attenuation of MAPK (Montrer MAPK1 Anticorps)-activated protein kinase (Montrer CDK7 Anticorps) (MK)-dependent mTOR (Montrer FRAP1 Anticorps) signaling after T cell receptor engagement, and enhanced their differentiation into regulatory T cells under appropriate inducing conditions.
Data indicate that alternatively activated p38alpha (Montrer MAPK14 Anticorps) and p38beta up-regulates the transcription factors NFATc1 (Montrer NFATC1 Anticorps) and IRF4 (Montrer IRF4 Anticorps).
the cell autonomous defect in self-renewal in satellite cells from aged mice is due to an impaired response to FGF ligands and elevated p38alpha (Montrer MAPK14 Anticorps)/beta MAPK (Montrer MAPK1 Anticorps) activity
work reveals a 'seed and soil' mechanism where TGF-beta2 (Montrer TGFB2 Anticorps) and TGF-beta (Montrer TGFB1 Anticorps)-RIII signalling through p38alpha (Montrer MAPK14 Anticorps)/beta regulates DTC dormancy and defines restrictive (BM) and permissive (lung) microenvironments for HNSCC metastasis
Results suggest that UBR2 (Montrer UBR2 Anticorps) up-regulation in cachectic muscle is mediated by the p38beta-C/EBPbeta (Montrer CEBPB Anticorps) signaling pathway responsible for the bulk of tumor-induced muscle proteolysis.
inhibition of the SOCE downstream target CaM kinase kinase beta (Montrer CAMKK2 Anticorps) (CaMKKbeta) or knockdown of AMPKalpha1 (Montrer PRKAA1 Anticorps) suppressed PAR-1 (Montrer MARK2 Anticorps)-mediated phosphorylation of p38beta and hence STIM1 (Montrer STIM1 Anticorps).
p27 (Montrer CDKN1B Anticorps) inhibition of COX-2 (Montrer COX2 Anticorps) expression was specifically due to phosphorylation of transcription factor cAMP response element binding (CREB (Montrer CREB1 Anticorps)) phosphorylation mediated by p38beta and p38delta (Montrer MAPK1/3 Anticorps).
p38beta MAPK (Montrer MAPK1 Anticorps) is dispensable in the brain in regards to proinflammatory cytokine production and neurotoxicity induced by LPS (Montrer TLR4 Anticorps) inflammatory insult
The protein encoded by this gene is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation, and development. This kinase is most closely related to p38 MAP kinase, both of which can be activated by proinflammatory cytokines and environmental stress. This kinase is activated through its phosphorylation by MAP kinase kinases (MKKs), preferably by MKK6. Transcription factor ATF2/CREB2 has been shown to be a substrate of this kinase.
mitogen-activated protein kinase 11
, mitogen-activated protein kinase 11-like
, MAP kinase 11
, MAP kinase p38 beta
, MAPK 11
, mitogen-activated protein kinase p38 beta
, mitogen-activated protein kinase p38-2
, stress-activated protein kinase 2
, stress-activated protein kinase 2b
, stress-activated protein kinase-2
, stress-activated protein kinase-2b
, mitogen activated protein kinase 11
, protein kinase, mitogen activated kinase, 11, p38beta