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Results provide evidence that p38beta is an unusual enzyme that automodulates its basal, MAPKK-independent activity by several autophosphorylation events, which enhance and suppress its catalytic activity.
p38beta was significantly higher in esophageal squamous cell carcinoma tissues compared with paired normal controls. p38beta expression was observed to be significantly associated with overall prognosis.
Suggest that R-Ras regulates angiogenic activities of endothelial cells in part via inhibition of the p38MAPK-HSP27 axis of VEGF signaling.
These findings suggest that coronin 1A (Montrer CORO1A Kits ELISA) modulates endothelial cell apoptosis by regulating p38beta expression and activation.
The MAPK11 gene was variably methylated in monozygotic twins discordant for depressive disorder.
p38beta is a novel regulatory target of the transcription factor Pokemon (Montrer ZBTB7A Kits ELISA) and positively regulated by Pokemon (Montrer ZBTB7A Kits ELISA) in hepatic cells.
Data show that the p38 MAPK (p38 (Montrer MAPK14 Kits ELISA)) isoform (p38beta) mitogen-activated protein kinase 11 (MAPK11) is expressed in breast cancer cell.
Differential roles for p38alpha (Montrer MAPK14 Kits ELISA) and p38beta in the HGF (Montrer HGF Kits ELISA)-induced expression of key osteogenic markers.
study identified the structural motif responsible for the unique autophosphorylation capability of p38beta and the motif inhibiting this activity in living cells
Study identifies Hsp27 (Montrer HSPB1 Kits ELISA) as a novel target of ILK (Montrer ILK Kits ELISA)-p38beta signaling complexes, playing a key role in bladder cancer cell migration.
propose that active p38-Mapk14 (Montrer MAPK14 Kits ELISA)/11 act as enablers, and Erk1/2 (Montrer MAPK1/3 Kits ELISA) as drivers, of primitive endoderm differentiation during inner cell mass lineage specification and segregation.
Double deficiency of p38alpha (Montrer MAPK14 Kits ELISA) and p38beta in naive CD4 (Montrer CD4 Kits ELISA)(+) T cells resulted in an attenuation of MAPK (Montrer MAPK1 Kits ELISA)-activated protein kinase (Montrer CDK7 Kits ELISA) (MK)-dependent mTOR (Montrer FRAP1 Kits ELISA) signaling after T cell receptor engagement, and enhanced their differentiation into regulatory T cells under appropriate inducing conditions.
Data indicate that alternatively activated p38alpha (Montrer MAPK14 Kits ELISA) and p38beta up-regulates the transcription factors NFATc1 (Montrer NFATC1 Kits ELISA) and IRF4 (Montrer IRF4 Kits ELISA).
the cell autonomous defect in self-renewal in satellite cells from aged mice is due to an impaired response to FGF ligands and elevated p38alpha (Montrer MAPK14 Kits ELISA)/beta MAPK (Montrer MAPK1 Kits ELISA) activity
work reveals a 'seed and soil' mechanism where TGF-beta2 (Montrer TGFB2 Kits ELISA) and TGF-beta (Montrer TGFB1 Kits ELISA)-RIII signalling through p38alpha (Montrer MAPK14 Kits ELISA)/beta regulates DTC dormancy and defines restrictive (BM) and permissive (lung) microenvironments for HNSCC metastasis
Results suggest that UBR2 (Montrer UBR2 Kits ELISA) up-regulation in cachectic muscle is mediated by the p38beta-C/EBPbeta (Montrer CEBPB Kits ELISA) signaling pathway responsible for the bulk of tumor-induced muscle proteolysis.
inhibition of the SOCE downstream target CaM kinase kinase beta (Montrer CAMKK2 Kits ELISA) (CaMKKbeta) or knockdown of AMPKalpha1 (Montrer PRKAA1 Kits ELISA) suppressed PAR-1 (Montrer MARK2 Kits ELISA)-mediated phosphorylation of p38beta and hence STIM1 (Montrer STIM1 Kits ELISA).
p27 (Montrer CDKN1B Kits ELISA) inhibition of COX-2 (Montrer COX2 Kits ELISA) expression was specifically due to phosphorylation of transcription factor cAMP response element binding (CREB (Montrer CREB1 Kits ELISA)) phosphorylation mediated by p38beta and p38delta (Montrer MAPK1/3 Kits ELISA).
p38beta MAPK (Montrer MAPK1 Kits ELISA) is dispensable in the brain in regards to proinflammatory cytokine production and neurotoxicity induced by LPS (Montrer TLR4 Kits ELISA) inflammatory insult
The protein encoded by this gene is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation, and development. This kinase is most closely related to p38 MAP kinase, both of which can be activated by proinflammatory cytokines and environmental stress. This kinase is activated through its phosphorylation by MAP kinase kinases (MKKs), preferably by MKK6. Transcription factor ATF2/CREB2 has been shown to be a substrate of this kinase.
mitogen-activated protein kinase 11
, mitogen-activated protein kinase 11-like
, MAP kinase 11
, MAP kinase p38 beta
, MAPK 11
, mitogen-activated protein kinase p38 beta
, mitogen-activated protein kinase p38-2
, stress-activated protein kinase 2
, stress-activated protein kinase 2b
, stress-activated protein kinase-2
, stress-activated protein kinase-2b
, mitogen activated protein kinase 11
, protein kinase, mitogen activated kinase, 11, p38beta