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anti-Mouse (Murine) MAPKAP Kinase 2 Anticorps:
anti-Human MAPKAP Kinase 2 Anticorps:
anti-Rat (Rattus) MAPKAP Kinase 2 Anticorps:
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Human Polyclonal MAPKAP Kinase 2 Primary Antibody pour DB, EIA - ABIN358152
Lukas, Kroe, Wildeson, Peet, Frego, Davidson, Ingraham, Pargellis, Labadia, Werneburg: Catalysis and function of the p38 alpha.MK2a signaling complex. dans Biochemistry 2004
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Human Polyclonal MAPKAP Kinase 2 Primary Antibody pour IF, IHC (p) - ABIN197078
Ben-Levy, Leighton, Doza, Attwood, Morrice, Marshall, Cohen: Identification of novel phosphorylation sites required for activation of MAPKAP kinase-2. dans The EMBO journal 1996
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Cow (Bovine) Polyclonal MAPKAP Kinase 2 Primary Antibody pour IF (p), IHC (p) - ABIN681523
Rosenzweig, Djap, Ou, Quinn: Mechanical injury of bovine cartilage explants induces depth-dependent, transient changes in MAP kinase activity associated with apoptosis. dans Osteoarthritis and cartilage / OARS, Osteoarthritis Research Society 2012
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Human Polyclonal MAPKAP Kinase 2 Primary Antibody pour IF, WB - ABIN197584
Rouse, Cohen, Trigon, Morange, Alonso-Llamazares, Zamanillo, Hunt, Nebreda: A novel kinase cascade triggered by stress and heat shock that stimulates MAPKAP kinase-2 and phosphorylation of the small heat shock proteins. dans Cell 1994
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a p38 MAPKAPK2 kinase cascade modulates the activity of F-actin at the yolk cell margin circumference allowing the gradual closure of the blastopore as epiboly progresses
this study shows that the loss of MK2 (Montrer KCNA2 Anticorps) in mast cells decreases the IL-33 (Montrer IL33 Anticorps)-induced leukocyte recruitment and the resulting skin inflammation
MK2 (Montrer KCNA2 Anticorps) signaling differentially regulated CCL3 (Montrer CCL3 Anticorps) and CCL4 (Montrer CCL4 Anticorps).
In silico analyses and experimental validation demonstrated that the kinase activity of p38(MAPK (Montrer MAPK14 Anticorps)) determines signal amplitude, whereas phosphatase activity affects both signal amplitude and duration. p38(MAPK (Montrer MAPK14 Anticorps)) and MK2 (Montrer KCNA2 Anticorps) concentrations and responsiveness toward IL-1beta (Montrer IL1B Anticorps) were quantitatively compared between hepatocytes and macrophages
MK2 (Montrer KCNA2 Anticorps)-activating peptide (MK2 (Montrer KCNA2 Anticorps)-AP) blocks the effects of anthrax lethal toxin on endothelial barriers in cultured cells and reduces pulmonary vascular leak in rats.
MK2 (Montrer KCNA2 Anticorps) regulates postnatal arteriogenesis by controlling vascular recruitment of monocytes/macrophages in dual manner: regulation of endothelial MCP-1 (Montrer CPT1B Anticorps) expression in response to hemodynamic and inflammatory forces as well as MCP-1 (Montrer CPT1B Anticorps) dependent monocyte migration
these data suggest there is a sexual dimorphism in MK2 (Montrer KCNA2 Anticorps) signaling of osteoclast progenitor cell subpopulations.
Loss of MK2 (Montrer KCNA2 Anticorps) effectively blocks bone resorption and prevents the development of postmenopausal bone loss.
This study showed that cmpd28, a Mapkapk2/3 inhibitor, represents a potentially new approach to type 2 diabetes therapy.
Deficiency of MK2 (Montrer KCNA2 Anticorps) prevents adverse remodelling and promotes endothelial healing of the arterial wall after injury.
high-fat diet-fed MK2 (Montrer KCNA2 Anticorps)-/- mice display decreased glucose tolerance and increased insulin (Montrer INS Anticorps) resistance compared to controls. Decreased adipose tissue expression of GLUT4 (Montrer SLC2A4 Anticorps) might contribute to this phenotype.
According to the information mentioned above, we now report the design and synthesis of some series of new urea derivatives that were then evaluated for their inhibitory activities against MAPKAPK2, TNF-a (Montrer TNF Anticorps), and p38a (Montrer MAPK14 Anticorps)
MK2 (Montrer KCNA2 Anticorps) post-transcriptionally regulates TNF-alpha (Montrer TNF Anticorps)-induced ICAM-1 (Montrer ICAM1 Anticorps) expression by altering the cytoplasmic localization of HuR (Montrer ELAVL1 Anticorps) in human lung microvascular endothelial cells.
MK2 (Montrer KCNA2 Anticorps) overexpression is associated with primary liver tumors.
CEP131 (Montrer AZI1 Anticorps) is the key regulatory target of MK2 (Montrer KCNA2 Anticorps) and 14-3-3 (Montrer YWHAQ Anticorps) in centriolar satellite remodeling.
mTOR (Montrer FRAP1 Anticorps) controls the senescence-associated secretory phenotype by differentially regulating the translation of the MK2 (Montrer KCNA2 Anticorps) (also known as MAPKAPK2).
analysis of signaling cooperation between p38-MAPK (Montrer MAPK14 Anticorps)/MAPKAP-2/Hsp27 (Montrer HSPB1 Anticorps) and intracellular calcium release in AA-induced HBEC apoptosis
findings reveal MK2 (Montrer KCNA2 Anticorps)/MK3 (Montrer KCNA3 Anticorps) as crucial stress-responsive kinases that promote autophagy through Beclin 1 (Montrer BECN1 Anticorps) S90 phosphorylation
The protein expression of both HMGB1 (Montrer HMGB1 Anticorps) and MAPKAPK2 were increased in KLM1-R cells.
Data indicate the binding mode and molecular mechanism of action of MAPK-activated protein kinase-2 (MK2) and inhibitors.
Treatment with MK2 (Montrer KCNA2 Anticorps) or p38 (Montrer CRK Anticorps) inhibitors blocked human papillomavirus genome amplification, identifying the p38 (Montrer CRK Anticorps)/MK2 (Montrer KCNA2 Anticorps) pathway as a key regulator of the human papillomavirus life cycle.
This gene encodes a member of the Ser/Thr protein kinase family. This kinase is regulated through direct phosphorylation by p38 MAP kinase. In conjunction with p38 MAP kinase, this kinase is known to be involved in many cellular processes including stress and inflammatory responses, nuclear export, gene expression regulation and cell proliferation. Heat shock protein HSP27 was shown to be one of the substrates of this kinase in vivo. Two transcript variants encoding two different isoforms have been found for this gene.
MAP kinase-activated protein kinase 2
, betty boop
, mitogen-activated protein kinase-activated protein kinase 2
, MAPK-activated protein kinase 2
, MAPKAP kinase 2
, map kinase activated protein kinase-2