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anti-Mouse (Murine) MAPKAP Kinase 5 Anticorps:
anti-Human MAPKAP Kinase 5 Anticorps:
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Human Monoclonal MAPKAP Kinase 5 Primary Antibody pour IHC, ELISA - ABIN969362
Paliga, Natale, Watson: p38 mitogen-activated protein kinase (MAPK) first regulates filamentous actin at the 8-16-cell stage during preimplantation development. dans Biology of the cell / under the auspices of the European Cell Biology Organization 2005
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Human Polyclonal MAPKAP Kinase 5 Primary Antibody pour IHC (p), WB - ABIN389587
Daily, Monks, Leggas, Moscow: Abrogation of microcystin cytotoxicity by MAP kinase inhibitors and N-acetyl cysteine is confounded by OATPIB1 uptake activity inhibition. dans Toxicon : official journal of the International Society on Toxinology 2010
Human Polyclonal MAPKAP Kinase 5 Primary Antibody pour ICC, IF - ABIN4347179
Stadler, Rexhepaj, Singan, Murphy, Pepperkok, Uhlén, Simpson, Lundberg: Immunofluorescence and fluorescent-protein tagging show high correlation for protein localization in mammalian cells. dans Nature methods 2013
MK5 haplodeficiency attenuated the progression of hypertrophy, reduced collagen type 1 mRNA, and protected diastolic function in response to chronic pressure overload.
An alternative targeting strategy of MK5/PRAK (termed MK5/PRAK-Deltaex6) increased neither tumor incidence in the one step skin carcinogenesis model, nor Ras-induced transformation in primary cells.
MK5 positively regulates Rag transcription via phosphorylation of Foxo1 (Montrer FOXO1 Anticorps) in developing B cells.
observations have demonstrated that PRAK is not required for either the rottlerin-mediated anti-chlamydial activity or rottlerin inhibition of sphingolipid trafficking, suggesting rottlerin may achieve its inhibitory role by targeting other host factors
Results suggest that PRAK may function as a tumor suppressor in multiple types of cancers.
the regulation of neuronal morphogenesis is proposed as the first physiological function of the ERK3 (Montrer RYK Anticorps)/MK5 signaling module
It was shown that the tumor-suppressing and tumor-promoting functions of the p38 (Montrer CRK Anticorps)-PRAK pathway are temporally and spatially separated during cancer development in vivo, relying on the stimulus, and the tissue type and the stage of cancer development.
Rheb (Montrer RHEB Anticorps) inactivation by PRAK-mediated phosphorylation is essential for energy-depletion-induced suppression of mTORC1
MK5 co-immunoprecipitated ERK3 (Montrer RYK Anticorps), but not ERK4 (Montrer MAPK4 Anticorps) or p38 alpha (Montrer MAPK14 Anticorps), in control and hypertrophying hearts (MK5).
Both binding and activation of p38 mitogen-activated protein kinase (Montrer MAPK14 Anticorps) (MAPK (Montrer MAPK1 Anticorps)) play essential roles in regulation of the nucleocytoplasmic distribution of MAPK-activated protein kinase 5 by cellular stress.
PRAK might be a potential therapeutic target of Alzheimer's disease involved in receptor for advanced glycation end products-mediated cell signaling induced by Abeta (Montrer APP Anticorps)
Plasma MAPKAPK5 protein was found to positively associate with the 10-year change in paired associates learning assessment in asymptomatic older twins.
Data highlight that DJ-1 (Montrer PARK7 Anticorps) is the downstream interacting target for PRAK, and in response to oxidative stress PRAK may exert a cytoprotective effect by facilitating DJ-1 (Montrer PARK7 Anticorps) to sequester Daxx (Montrer DAXX Anticorps) in the nucleus, thus preventing cell death.
Data indicate that the structurally most flexible regions during molecular dynamics (MD) simulations of the native mitogen-activated protein kinase (Montrer MAPK1 Anticorps)-activated protein kinase (Montrer CDK7 Anticorps) MK5 model were the loop regions.
Studies with specific phosphoantibodies indicate that MK5 phosphorylates Hsp40/DnaJB1 (Montrer DNAJB1 Anticorps) in vivo at Ser (Montrer SIGLEC1 Anticorps)-149 or/and Ser (Montrer SIGLEC1 Anticorps)-151 and Ser (Montrer SIGLEC1 Anticorps)-171 in the C-terminal domain of Hsp40/DnaJB1 (Montrer DNAJB1 Anticorps).
study shows Tip60 (Montrer KAT5 Anticorps) plays an essential role in oncogenic ras-induced senescence; revealed a cascade of posttranslational modifications involving p38 (Montrer CRK Anticorps), Tip60 (Montrer KAT5 Anticorps) and PRAK, 3 proteins essential for ras-induced senescence; these modifications are critical for prosenescent function of Tip60 (Montrer KAT5 Anticorps) and PRAK
these results firstly demonstrate that MK5 is degraded in response to doxorubicin and negatively regulates doxorubicin-induced apoptosis, providing novel insights into the molecular mechanism of doxorubicin resistance in hepatoma cells.
IGF2BP1 (Montrer IGF2BP1 Anticorps) promotes the velocity and directionality of tumor-derived cell migration by determining the cytoplasmic fate of two novel target mRNAs: MAPK4 (Montrer MAPK4 Anticorps) and PTEN (Montrer PTEN Anticorps)
Activation loop phosphorylation of ERK3/ERK4 (Montrer MAPK4 Anticorps) by group I p21 (Montrer CDKN1A Anticorps)-activated kinases (PAKs) defines a novel PAK-ERK3 (Montrer MAPK4 Anticorps)/4-MAPK-activated protein kinase 5 signaling pathway.
The protein encoded by this gene is a tumor suppressor and member of the serine/threonine kinase family. In response to cellular stress and proinflammatory cytokines, this kinase is activated through its phosphorylation by MAP kinases including MAPK1/ERK, MAPK14/p38-alpha, and MAPK11/p38-beta. The encoded protein is found in the nucleus but translocates to the cytoplasm upon phosphorylation and activation. This kinase phosphorylates heat shock protein HSP27 at its physiologically relevant sites. Two alternately spliced transcript variants of this gene encoding distinct isoforms have been reported.
mitogen-activated protein kinase-activated protein kinase 5
, MAP kinase-activated protein kinase 5
, MAP kinase-activated protein kinase 5-like
, MAPK-activated protein kinase 5
, MAPKAP kinase 5
, p38-regulated/activated protein kinase