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anti-Human RAF1 Anticorps:
anti-Rat (Rattus) RAF1 Anticorps:
anti-Mouse (Murine) RAF1 Anticorps:
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Human RAF1 Primary Antibody pour IHC - ABIN966940
Gabriel, Bravery, Dougherty, Kayley, Malster, Scales: Vascular access: indications and implications for patient care. dans Nursing standard (Royal College of Nursing (Great Britain) : 1987) 2005
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Human Polyclonal RAF1 Primary Antibody pour DB, ELISA - ABIN4369727
Gohlke, Kuhn, Case: Change in protein flexibility upon complex formation: analysis of Ras-Raf using molecular dynamics and a molecular framework approach. dans Proteins 2004
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Human Monoclonal RAF1 Primary Antibody pour WB - ABIN260776
Chiloeches, Mason, Marais: S338 phosphorylation of Raf-1 is independent of phosphatidylinositol 3-kinase and Pak3. dans Molecular and cellular biology 2001
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Human Monoclonal RAF1 Primary Antibody pour FACS, IHC - ABIN969560
Takezawa, Okamoto, Yonesaka, Hatashita, Yamada, Fukuoka, Nakagawa: Sorafenib inhibits non-small cell lung cancer cell growth by targeting B-RAF in KRAS wild-type cells and C-RAF in KRAS mutant cells. dans Cancer research 2009
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Human Monoclonal RAF1 Primary Antibody pour FACS, IHC - ABIN969559
Hofmann, Heinrich, Radziwill, Radziwil, Moelling: A short hairpin DNA analogous to miR-125b inhibits C-Raf expression, proliferation, and survival of breast cancer cells. dans Molecular cancer research : MCR 2009
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Human Polyclonal RAF1 Primary Antibody pour IHC, WB - ABIN361884
Dougherty, Müller, Ritt, Zhou, Zhou, Copeland, Conrads, Veenstra, Lu, Morrison: Regulation of Raf-1 by direct feedback phosphorylation. dans Molecular cell 2005
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Human Polyclonal RAF1 Primary Antibody pour IHC, WB - ABIN362494
Fabian, Daar, Morrison: Critical tyrosine residues regulate the enzymatic and biological activity of Raf-1 kinase. dans Molecular and cellular biology 1993
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Human Polyclonal RAF1 Primary Antibody pour IP, IHC - ABIN222938
Ito, Nagayasu, Okumura-Noji, Lu, Nishida, Miura, Asai, Kheirollah, Nakaya, Yokoyama: Mechanism for FGF-1 to regulate biogenesis of apoE-HDL in astrocytes. dans Journal of lipid research 2007
Human Polyclonal RAF1 Primary Antibody pour IF (p), IHC (p) - ABIN733208
Wang, Fu, Jiang, Yu, Wang, Han, Liu, Wang: Bone marrow mononuclear cell transplantation promotes therapeutic angiogenesis via upregulation of the VEGF-VEGFR2 signaling pathway in a rat model of vascular dementia. dans Behavioural brain research 2014
Human Polyclonal RAF1 Primary Antibody pour IF (p), IHC (p) - ABIN712706
Wu, Dong, Shi, Yu, Fu, Zhang, Cai, Zhao, Peng, Wu, Wu: Regulation of integrin ?V subunit expression by sulfatide in hepatocellular carcinoma cells. dans Journal of lipid research 2013
Results indicate that des (Montrer DES Anticorps)-gamma-carboxy prothrombin (Montrer F2 Anticorps) (DCP (Montrer ACE Anticorps)) antagonizes the inhibitory effects of Sorafenib on hepatocellular carcinoma (HCC (Montrer FAM126A Anticorps)) through activation of the Raf/MEK (Montrer MAP2K1 Anticorps)/ERK (Montrer EPHB2 Anticorps) and PI3K (Montrer PIK3CA Anticorps)/Akt (Montrer AKT1 Anticorps)/mTOR (Montrer FRAP1 Anticorps) signaling pathways.
DiRas3 (Montrer DIRAS3 Anticorps) binds to KSR1 (Montrer KSR1 Anticorps) independently of its interaction with activated Ras and RAF.
RhoA (Montrer RHOA Anticorps)/ROCK and Raf-1/CK2 (Montrer CSNK2A1 Anticorps) pathway are responsible for TNF-alpha (Montrer TNF Anticorps)-mediated endothelial cytotoxicity via regulation of the vimentin (Montrer VIM Anticorps) cytoskeleton.
Although Raf-1 gene is not mutated, an abnormality of Raf-1 kinase feedback regulation enhances its antiapoptotic function, and Raf-1 can still be a pharmaceutical target to increase chemotherapy or radiotherapy sensitivity in these cancer cells.
RAF1 plays a critical role in maintaining the transformed phenotype of CRC cells, including those with mutated KRAS.
This finding suggests that stringent assemblage of Hsp90 (Montrer HSP90 Anticorps) keeps CRAF kinase equipped for participating in the MAPK (Montrer MAPK1 Anticorps) pathway. Thus, the role of Hsp90 (Montrer HSP90 Anticorps) in CRAF maturation and activation acts as a limiting factor to maintain the function of a strong client like CRAF kinase.
Oncogenic NFIA:RAF1 fusion activation of the MAPK (Montrer MAPK1 Anticorps) pathway is associated with pilocytic astrocytoma.
IGF2BP2 (Montrer IGF2BP2 Anticorps) as a post-transcriptional regulatory mRNA-binding factor, interfering with Raf-1 degradation by miR (Montrer MLXIP Anticorps)-195, that contributes to Colorectal carcinogenesis.
Data show that when microRNA miR (Montrer MLXIP Anticorps)-125b was over-expressed in THP-1 (Montrer GLI2 Anticorps) macrophages, the expression of Raf1 proto-oncogene (Montrer RAB1A Anticorps) serine/threonine protein kinase (RAF1) was reduced to promote the apoptosis of macrophages.
Data show that Griffipavixanthone (GPX (Montrer GPX1 Anticorps)), a dimeric xanthone isolated from Garcinia esculenta, is a B-RAF (Montrer SNRPE Anticorps) and C-RAF inhibitor against esophageal cancer cells.
cdk10 (Montrer CDK10 Anticorps) has roles in vertebrate development and a critical function in neurogenesis by modulation of raf1a expression
Our results indicate that Rb-Raf-1 interaction plays an important role in spontaneous hair cell regeneration in zebrafish
Zebrafish embryos with morpholino knockdown of raf1 demonstrated the need for raf1 for the development of normal myocardial structure and function.
analysis of the roles of Raf- and PI3K-signalling pathways in melanoma
data suggest that G alpha(i3), Shc (Montrer SHC1 Anticorps), Grb2 (Montrer GRB2 Anticorps), Ras, and Raf-1 link Src (Montrer SRC Anticorps) to activation of MAPK (Montrer MAPK1 Anticorps) and to the AT(2)-dependent increase in eNOS (Montrer NOS3 Anticorps) expression in PAECs
BRAF (Montrer BRAF Anticorps) and ROKalpha (Montrer ROCK2 Anticorps) form independent RAF1 complexes in embryonic fibroblasts (MEFs) treated with epidermal growth factor (EGF (Montrer EGF Anticorps)).
Mechanistically, BRAF (Montrer BRAF Anticorps) and RAF1 operate independently to balance MAPK (Montrer MAPK1 Anticorps) signaling: BRAF (Montrer BRAF Anticorps) promotes ERK (Montrer EPHB2 Anticorps) activation, while RAF1 dims stress kinase activation.
Neuroprotective (arylthio)cyclopentenone prostaglandins directly bind to c-Raf protein and protect cells from down-regulation of the c-Raf protein itself, resulting in protection against oxidative stress.
A- and B-Raf ablation in chondrocytes does not alter skeletal development, whereas ablation of C-Raf decreases hypertrophic chondrocyte apoptosis and impairs vascularization of the growth plate. However, ablation of C-Raf does not impair phosphate-induced ERK1/2 phosphorylation in vitro, but leads to rickets by decreasing VEGF protein stability.
We confirmed that Raf1(L613V) knock-in confers a NS-like phenotype, including cardiac hypertrophy. Active RSK3 (Montrer RPS6KA2 Anticorps) was increased in Raf1(L613V) mice. Constitutive RSK3 (Montrer RPS6KA2 Anticorps) gene deletion prevented the Raf1(L613V)-dependent concentric growth in width of the cardiac myocyte and attenuated cardiac hypertrophy in female mice.
C-Raf involves in osteoblast survival in response to mechanical stress.
Dual inhibition of c-Raf and soluble epoxide hydrolase (Montrer EPHX2 Anticorps) by t-CUPM prevents mutant KrasG12D-initiated murine pancreatic carcinoma growth.
Simultaneous inhibition of sEH (Montrer EPHX2 Anticorps) and c-RAF prevents chronic pancreatitis and murine pancreatic intraepithelial neoplasia in LSL-KrasG(1)(2)D/Pdx-1 (Montrer PDX1 Anticorps)-Cre mice.
under normal physiological conditions, PTEN (Montrer PTEN Anticorps) suppresses AKT (Montrer AKT1 Anticorps) activity to maintain activation of the RAF1/ERK (Montrer EPHB2 Anticorps) signaling pathway, which in turn maintains normal function of the initial segment and therefore, normal sperm maturation.
these data indicate that B-RAF (Montrer SNRPE Anticorps) is an important factor in oncogenic C-RAF-mediated tumorigenesis.
Both c-Raf and B-Raf (Montrer BRAF Anticorps) are required for Ras-induced MEK1 (Montrer MAP2K1 Anticorps) and p42 (Montrer EPB42 Anticorps) MAP kinase (Montrer MAPK1 Anticorps) activation.
This gene is the cellular homolog of viral raf gene (v-raf). The encoded protein is a MAP kinase kinase kinase (MAP3K), which functions downstream of the Ras family of membrane associated GTPases to which it binds directly. Once activated, the cellular RAF1 protein can phosphorylate to activate the dual specificity protein kinases MEK1 and MEK2, which in turn phosphorylate to activate the serine/threonine specific protein kinases, ERK1 and ERK2. Activated ERKs are pleiotropic effectors of cell physiology and play an important role in the control of gene expression involved in the cell division cycle, apoptosis, cell differentiation and cell migration. Mutations in this gene are associated with Noonan syndrome 5 and LEOPARD syndrome 2.
, RAF proto-oncogene serine/threonine-protein kinase
, proto-oncogene c-RAF
, raf proto-oncogene serine/threonine protein kinase
, murine leukemia viral (v-raf-1) oncogene homolog 1 (3611-MSV)
, v-raf-1 murine leukemia viral oncogene homolog 1
, murine leukemia viral oncogene homolog
, serine/threonine protein kinase RAF1
, MIL proto-oncogene serine/threonine-protein kinase
, c-mil protein
, murine leukemia viral (v-raf-1) oncogene homolog 1
, RAF proto-oncogene serine/threonine-protein kinase-like
, Craf1 transforming
, murine sarcoma 3611 oncogene 1
, sarcoma 3611 oncogene
, v-raf-1 leukemia viral oncogene 1
, Proto-oncogene c-RAF