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Human EGFR Kit ELISA pour Sandwich ELISA - ABIN411266
Achmad, Hanaoka, Yoshioka, Yamamoto, Tominaga, Araki, Ohshima, Oriuchi, Endo: Predicting cetuximab accumulation in KRAS wild-type and KRAS mutant colorectal cancer using 64Cu-labeled cetuximab positron emission tomography. dans Cancer science 2012
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Human EGFR Kit ELISA pour Sandwich ELISA - ABIN417184
Russo: Increased Epidermal Growth Factor Receptor (EGFR) Associated with Hepatocyte Growth Factor (HGF) and Symptom Severity in Children with Autism Spectrum Disorders (ASDs). dans Journal of central nervous system disease 2014
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Human EGFR Kit ELISA pour Cell ELISA - ABIN1981825
Hubbard, Wei, Ellis, Hendrickson: Crystal structure of the tyrosine kinase domain of the human insulin receptor. dans Nature 1995
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Human EGFR Kit ELISA pour Cell ELISA - ABIN1981827
Hackel, Zwick, Prenzel, Ullrich: Epidermal growth factor receptors: critical mediators of multiple receptor pathways. dans Current opinion in cell biology 1999
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Human EGFR Kit ELISA pour Sandwich ELISA - ABIN625223
Maurya, Rai, Rai, Deshpande, Jain, Mudiam, Prabhakar, Bandyopadhyay: Cypermethrin induces astrocyte apoptosis by the disruption of the autocrine/paracrine mode of epidermal growth factor receptor signaling. dans Toxicological sciences : an official journal of the Society of Toxicology 2012
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Human EGFR Kit ELISA pour Sandwich ELISA - ABIN624965
Maramotti, Paci, Miccichè, Ciarrocchi, Cavazza, De Bortoli, Vaghi, Formisano, Canovi, Sgarbi, Bongarzone: Soluble epidermal growth factor receptor isoforms in non-small cell lung cancer tissue and in blood. dans Lung cancer (Amsterdam, Netherlands) 2012
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Human EGFR Kit ELISA pour Cell ELISA - ABIN1981821
Wang, Patil, Li, Humphrey, Brattain, Howell: Activation of the TGFalpha autocrine loop is downstream of IGF-I receptor activation during mitogenesis in growth factor dependent human colon carcinoma cells. dans Oncogene 2002
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Human EGFR Kit ELISA pour Cell ELISA - ABIN1981829
Kanai, Konda, Nakajima, Izumi, Kanda, Nanakin, Kubohara, Chiba: Differentiation-inducing factor-1 (DIF-1) inhibits STAT3 activity involved in gastric cancer cell proliferation via MEK-ERK-dependent pathway. dans Oncogene 2003
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Human EGFR Kit ELISA pour Cell ELISA - ABIN1981823
Biscardi, Maa, Tice, Cox, Leu, Parsons: c-Src-mediated phosphorylation of the epidermal growth factor receptor on Tyr845 and Tyr1101 is associated with modulation of receptor function. dans The Journal of biological chemistry 1999
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Results indicated that most periocular squamous cell carcinomas of horses expressed epidermal growth factor receptor (EGFR) and human epidermal growth factor receptor 2 (HER2 (Montrer ERBB2 Kits ELISA)).
Graf (Montrer ARHGAP26 Kits ELISA) functions to downregulate EGFR signaling.
Data show that EGFR controls the proper formation of brain neuroblasts by regulating the number, survival and proneural gene expression of neuroectodermal progenitor cells which suggest that EGFR signalling is crucially important for patterning and early neurogenesis of the brain.
The activity of Gro (Montrer CXCL1 Kits ELISA) is antagonized by EGFR signaling, which inhibits Gro (Montrer CXCL1 Kits ELISA)-dependent repression via p-ERK (Montrer MAPK1 Kits ELISA) mediated phosphorylation.
These results reveal that ESCRT-0 (ESCRT-0 components stam (Montrer STAM Kits ELISA) and hrs)mutants inhibit EGFR signaling by disrupting Rhomboid endosomal trafficking in the ligand-producing cells.
we find that EGFR regulates the apical determinant Crb and the extracellular matrix regulator Serp, two factors previously known to control tube length. EGFR regulates the organisation of endosomes in which Crb and Serp proteins are loaded
Here we uncover a cell non-autonomous requirement for the Epidermal growth factor receptor (Egfr) pathway in the lateral epidermis for sustained dpp (Montrer TGFb Kits ELISA) expression in the LE. Specifically, we demonstrate that Egfr pathway activity in the lateral epidermis prevents expression of the gene scarface (scaf), encoding a secreted antagonist of JNK (Montrer MAPK8 Kits ELISA) signaling
Loss of Usp5 (Montrer USP5 Kits ELISA) results in upregulation of Notch (Montrer NOTCH1 Kits ELISA) signaling and downregulation of RTK signaling by EGF receptor (EGFR) and Sevenless (Sev), leading to impaired photoreceptor development.
These data demonstrate a strong genetic link between dG9a and the EGFR signaling pathway.
Avermectin directly interacts with EGFR and leads to the activation of the EGFR/AKT (Montrer AKT1 Kits ELISA)/ERK (Montrer MAPK1 Kits ELISA) pathway.
The dorsoventral patterning and EGFR signaling genes play essential roles in correct identity determination and differentiation of lateral glia in the Drosophila nervous system.
Study demonstrated that IGF-I (Montrer IGF1 Kits ELISA) can stimulate egfr expression in both follicles cell culture and intact follicles promoting oocyte maturation.
These results indicate that maintenance of Pgrmc1 (Montrer PGRMC1 Kits ELISA) signaling is required for Egfr expression on zebrafish oocyte cell membranes and for conserving the functions of Egfr in maintaining meiotic arrest through estrogen activation of Gper (Montrer GPER Kits ELISA).
EGFR signaling in vertebrate oocytes can prevent meiotic progression.
the expression of EGFR was mainly restricted to the follicle cells with little expression in the oocytes
Leptomeningeal metastases were much more frequent in patients with non-small cell lung cancer harboring EGFR mutations
Epidermal growth factor (EGF (Montrer EGF Kits ELISA)) stimulates H2O2 production in a calcium-dependent way.Downregulation of Duox1 (Montrer DUOX1 Kits ELISA) or DuoxA1 (Montrer DUOXA1 Kits ELISA) expression abolishes the EGF (Montrer EGF Kits ELISA)-evoked H2O2 production.
A drop in plasma-mutant EGFR levels to =10 molecules/mL was seen by day 21 of treatment in 7 of 8 patients with documented partial response.
Combined EGFR and ROCK inhibition effectively blocks proliferation of triple-negative breast cancer (TNBC) cells.
The combined biomarkers E-cadherin (Montrer CDH1 Kits ELISA), membranous epidermal growth factor receptor (EGFR) and vimentin (Montrer VIM Kits ELISA) show a stronger prognostic value for and disease-free survival than any of the single biomarkers.
NSCLCs harboring EGFR mutations or ALK (Montrer ALK Kits ELISA) rearrangements are associated with low ORRs to PD-1 (Montrer PDCD1 Kits ELISA)/PD-L1 (Montrer CD274 Kits ELISA) inhibitors. Low rates of concurrent PD-L1 (Montrer CD274 Kits ELISA) expression and CD8 (Montrer CD8A Kits ELISA)(+) TILs within the tumor microenvironment may underlie these clinical observations.
this study is the first to show that a membrane-located tyrosine kinase receptor (Montrer NTRK1 Kits ELISA), such as EGFR, is internalized to a nuclear/perinuclear location upon exposure to stress and modulates the stability and translation of miRNA-selected mRNAs.
Noninvasive assays for evaluation of acquired resistance to first-line EGFR TKIs.
Induced by former systemic therapy, there were more T790M (18%), concomitant EGFR mutations (15%), and changes to EGFR wild type (19%) in the MR group among patients with EGFR mutations, which indicated higher incidence of genetic heterogeneity
This article explains the options available after progression on initial EGFR TKI therapy and the importance of molecular testing at progression in making making treatment decisions
YAP (Montrer YAP1 Kits ELISA) accumulated in nuclei of mammary glands in ErbB2 (Montrer ERBB2 Kits ELISA)/EGFR-transgenic mice, suggesting that EGFR signaling affects YAP (Montrer YAP1 Kits ELISA) in vivo similar to cell culture. ErbB2 (Montrer ERBB2 Kits ELISA)/EGFR-transgenic mice develop mammary tumors in 7-8 months, but surprisingly, MaSCs from these mice did not form tumors when transplanted into host mice.
Findings suggest that sEGFR might be a biomarker for evaluating insulin (Montrer INS Kits ELISA) resistance or a therapeutic target of liraglutide.
Xenoestrogens biphenol-A and nonylphenol stimulate the release of EGFR-ligands by differentially activating ADAM17 (Montrer ADAM17 Kits ELISA) or ADAM10 (Montrer ADAM10 Kits ELISA).
Data suggest that simultaneous inhibition of mTOR (Montrer FRAP1 Kits ELISA) and EGFR or MEK (Montrer MDK Kits ELISA) may be more effective in treating colon cancer.
Data indicate alpha-P85 (Montrer ECM1 Kits ELISA) Subunit, PI-3K (p85alpha) as a positive regulator of epidermal growth factor receptor (EGFR) expression and cell malignant transformation via nucleolin (Montrer NCL Kits ELISA)-dependent mechanism.
through the activation of EGFR, MET activation parallels a RAS pathway to contribute to human and mouse cutaneous cancers.
OLIG2 (Montrer OLIG2 Kits ELISA) modulates growth factor signaling in two distinct populations of glioma stem cells, characterized by expression of either the epidermal growth factor receptor (EGFR) or platelet-derived growth factor receptor alpha (Montrer PDGFRA Kits ELISA).
Data indicate that interleukin-33 (IL-33 (Montrer IL33 Kits ELISA))-induced Interleukin-13 (IL-13 (Montrer IL13 Kits ELISA)) production by type-2 helper T cells (Th2 cells) Is dependent on epidermal growth factor receptor (EGFR) expression.
The EGFR-mediated control of beta-cell differentiation via apical polarity is also conserved in human neurogenin3 (Montrer NEUROG3 Kits ELISA)(+) cells.
Epiregulin (Montrer EREG Kits ELISA) and EGFR interactions have roles in pain processing
this study shows that anemonin may ameliorate LPS (Montrer IRF6 Kits ELISA)-induced intestinal injury and improve restoration by regulating the TGF-b1 and EGFR signaling pathways
Syndecan-4 (Montrer SDC4 Kits ELISA) mediates porcine respiratory and reproductive syndrome virus entry by interacting with EGFR.
These results indicate that cAMP and oocyte-secreted factors cooperate to promote EGF receptor functionality in developing cumulus oocyte complexes, representing a key component of the acquisition of oocyte developmental competence.
patients experiencing gefitinib dose reduction or short-term treatment interruption due to toxicities did not show inferior survival, compared to those receiving full dose of gefitinib in non-small cell lung cancer patients with EGFR mutation
Report EGFR expression in the normal pancreas.
Injury and activation of purinergic receptors and direct activation of EGFR via EGF (Montrer EGF Kits ELISA) induce distinct downstream pathways.
Data suggest that the mechanism of hypoxia-induced increased activation of EGFR kinase is mediated by nNOS (Montrer NOS1 Kits ELISA)-derived nitric oxide.
EGFR, VEGFR (Montrer KDR Kits ELISA) and FGFR (Montrer FGFR2 Kits ELISA) are expressed in porcine oviduct and endometrium during the time of implantation [review]
the restricted presence of the functional full-size receptor to the epithelial layer indicates a specific role during early embryonic development, whereas truncated EGF-R forms may potentially regulate contractions and blood flow in the oviduct
The phase-related expression of EGF (Montrer EGF Kits ELISA) and EGFR in the endothelium of the uterine artery and its branches suggest the modulatory effect of EGF (Montrer EGF Kits ELISA) and its receptor on the uterine artery and the region supplying these vessels.
Stimulation of bovine oviduct epithelial cell EGFR with EGF (Montrer EGF Kits ELISA) (human recombinant EGF (Montrer EGF Kits ELISA)) alone or with EGF (Montrer EGF Kits ELISA) in postovulatory/follicular phases (not luteal phase) up-regulates phosphorylation of MAPKs; heat blocks effects of EGF (Montrer EGF Kits ELISA) on phosphorylation of MAPKs.
Expression of the erbB/HER receptor family in the bovine uterus during the sexual cycle and the relation of this family to serum sex steroids.
Regulation of the sperm EGFR by ouabain leads to initiation of the acrosome reaction.
EGFR may simultaneously activate c-Src (Montrer SRC Kits ELISA) and PI3K to amplify the oxytocin signaling to increase the output of PGF (Montrer PGF Kits ELISA)(2 alpha) in endometrial epithelial cells.
results indicate that arginase induction depends in part on epidermal growth factor (EGF (Montrer EGF Kits ELISA)) receptor activity, and that EGFR inhibitors may attenuate vascular remodeling without affecting nitric oxide release
Data suggest that epidermal growth factor (EGF (Montrer EGF Kits ELISA)) and EGF (Montrer EGF Kits ELISA) receptors are important paracrine and/or autocrine regulators of spermatogenesis in bovine.
MT1-MMP (Montrer MMP14 Kits ELISA) has a role in signaling events mediating EGFR transactivation
possible cooperative role of the EGF (Montrer EGF Kits ELISA) and HGF (Montrer HGF Kits ELISA) pathways and indicate that cross-talk between their respective receptors may modulate mammary gland development in the cow
EGFR is stimulated during capacitation via PKA activation. More activation induces the acrosome reaction, which is induced by GPCR via EGFR transactivation by a signaling pathway involving PKA, SRC & metalloproteinase & effectors PI3K, PLC & PKC.
The protein encoded by this gene is a transmembrane glycoprotein that is a member of the protein kinase superfamily. This protein is a receptor for members of the epidermal growth factor family. EGFR is a cell surface protein that binds to epidermal growth factor. Binding of the protein to a ligand induces receptor dimerization and tyrosine autophosphorylation and leads to cell proliferation. Mutations in this gene are associated with lung cancer. Multiple alternatively spliced transcript variants that encode different protein isoforms have been found for this gene.
, Egf receptor
, drosophila epidermal growth factor receptor homologue
, ellipse torpedo
, epidermal growth factor receptor
, faint little ball
, morphological defects 1
, avian erythroblastic leukemia viral (v-erb-b) oncogene homolog
, cell growth inhibiting protein 40
, cell proliferation-inducing protein 61
, proto-oncogene c-ErbB-1
, receptor tyrosine-protein kinase erbB-1
, EGFR-related peptide
, Epidermal growth factor receptor formerly avian erythroblastic leukemia viral (v-erbB) oncogene homolog (Erbb1)
, avian erythroblastic leukemia viral (v-erbB) oncogene homolog
, epidermal growth factor receptor, formerly avian erythroblastic leukemia viral (v-erbB) oncogene homolog (Erbb1)
, waved 2
, epidermal growth factor receptor (erythroblastic leukemia viral (v-erb-b) oncogene homolog, avian)
, egf receptor
, receptor tyrosine kinase ErbB1