Use your antibodies-online credentials, if available.
Il n’y a pas de produits dans votre liste de comparaison.
Votre panier est vide.
Afficher toutes les espèces
Afficher tous les synonymes
Select your species
TAK1 regulates Nrf2 (Montrer GABPA Kits ELISA) through modulation of Keap-p62/SQSTM1 (Montrer SQSTM1 Kits ELISA) interaction. This regulation is important for homeostatic antioxidant protection in the intestinal epithelium.
Overexpression of TAK1 was strongly associated with positive lymph node metastasis in pancreatic ductal adenocarcinoma.
dysregulation of the TAK1 complex produces a close phenocopy of Frontometaphyseal Dysplasia caused by FLNA (Montrer FLNA Kits ELISA) mutations; furthermore, the pathogenesis of some of the filaminopathies caused by FLNA (Montrer FLNA Kits ELISA) mutations might be mediated by misregulation of signaling coordinated through the TAK1 signaling complex
although TAK1 is located at the crossroad of inflammation, immunity, and cancer, this study reports MAP3K7 mutations in a developmental disorder affecting mainly cartilage, bone, and heart
This study suggests that aberrant activity of TAK1 impairs autophagy and subsequently leads to alterations in the vitality of retinal pigment epithelial cells.
TAK1 may be an important factor involved in the pathogenesis of thyroid cancer, and targeted down-regulation of TAK1 may improve the prognosis of patients with thyroid cancer.
Loss of MAP3K7 are associated with esophageal squamous cell carcinoma.
This paper highlights that targeting the BMP and TGFbeta (Montrer TGFB1 Kits ELISA) type I and type II receptors causes a downregulation of XIAP (Montrer XIAP Kits ELISA), TAK1, and Id1 (Montrer ID1 Kits ELISA) leading to cell death of lung cancer cells.
Polyubiquitination of Transforming Growth Factor beta-activated Kinase 1 (TAK1) at Lysine 562 Residue Regulates TLR4 (Montrer TLR4 Kits ELISA)-mediated JNK (Montrer MAPK8 Kits ELISA) and p38 MAPK (Montrer MAPK14 Kits ELISA) Activation
The data emphasize the central role of TAK1 in controlling signaling cascades and functional responses in primary neutrophils, making it a promising target for therapeutic intervention in view of the role of neutrophils in chronic inflammatory conditions.
Tnfr1 (Montrer TNFRSF1A Kits ELISA) deletion partially restored thymic and lung macrophages.
TAK1 (Montrer NR2C2 Kits ELISA) is required for PPARgamma (Montrer PPARG Kits ELISA) transactivation and promotes PPARgamma (Montrer PPARG Kits ELISA) transcriptional activity synergistically with TAK1 binding protein 1 (TAB1 (Montrer TAB1 Kits ELISA)).
inhibition of TAK1 (Montrer NR2C2 Kits ELISA) triggered two caspase 8 (Montrer CASP8 Kits ELISA) activation pathways through the induction of RIP1 (Montrer RALBP1 Kits ELISA)-FADD (Montrer FADD Kits ELISA)-caspase 8 (Montrer CASP8 Kits ELISA) complex as well as FLIP cleavage/degradation.
Transforming growth factor-beta activated kinase 1 (TAK1) regulation of sterol-regulatory element-binding proteins (SREBPs) critically contributes to the maintenance of liver homeostasis to prevent steatosis, which is a potentially important mechanism to prevent hepatocellular carcinoma (HCC (Montrer FAM126A Kits ELISA)) development.
TAK1 (Montrer NR2C2 Kits ELISA) regulates Nrf2 (Montrer NFE2L2 Kits ELISA) through modulation of Keap-p62/SQSTM1 (Montrer SQSTM1 Kits ELISA) interaction. This regulation is important for homeostatic antioxidant protection in the intestinal epithelium.
Mekk1 (Montrer MAP2K1 Kits ELISA) (encoded by Map3k1 (Montrer MAP3K1 Kits ELISA)) signaling activates Mapks to regulate Cdkn1b (Montrer CDKN1B Kits ELISA) (encoding p27(Kip1 (Montrer CDKN1B Kits ELISA))) expression and p27(Kip1 (Montrer CDKN1B Kits ELISA))-dependent proliferative expansion in response to antigen.
TRADD (Montrer TRADD Kits ELISA) knockout blunts pressure overload-induced cardiac hypertrophy through mediating TAK1 (Montrer NR2C2 Kits ELISA)/p38 MAPK (Montrer MAPK14 Kits ELISA) but not AKT (Montrer AKT1 Kits ELISA) phosphorylation
this study demonstrates a pivotal role of TAK1 (Montrer NR2C2 Kits ELISA) in dendritic cells in controlling trichloroethylene-induced contact hypersensitivity response and suggests that targeting TAK1 (Montrer NR2C2 Kits ELISA) function in DCs may be a viable approach to preventing and treating TCE-related occupational health hazards
The E3 ligase TRIM8 (Montrer TRIM8 Kits ELISA) is a potent regulator that exacerbates steatohepatitis and metabolic disorders dependent on its binding and ubiquitinating capacity on transforming growth factor-beta-activated kinase 1.
Angiotensin-II up-regulates the Ampkalpha1 (Montrer PRKAA1 Kits ELISA) isoform in renal tissue. Ampkalpha1 (Montrer PRKAA1 Kits ELISA) participates in renal Tak1 (Montrer NR2C2 Kits ELISA) activation and Tak1 (Montrer NR2C2 Kits ELISA)-dependent signaling induced by angiotensin-II.
The protein encoded by this gene is a member of the serine/threonine protein kinase family. This kinase mediates the signaling transduction induced by TGF beta and morphogenetic protein (BMP), and controls a variety of cell functions including transcription regulation and apoptosis. In response to IL-1, this protein forms a kinase complex including TRAF6, MAP3K7P1/TAB1 and MAP3K7P2/TAB2\; this complex is required for the activation of nuclear factor kappa B. This kinase can also activate MAPK8/JNK, MAP2K4/MKK4, and thus plays a role in the cell response to environmental stresses. Four alternatively spliced transcript variants encoding distinct isoforms have been reported.
mitogen-activated protein kinase kinase kinase 7
, TGF-beta-activated kinase TAK1
, TGF-beta activated kinase 1
, TGF-beta-activated kinase 1
, transforming growth factor-beta-activated kinase 1
, mitogen activated protein kinase kinase kinase 7
, transforming growth factor beta-activated kinase 1