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anti-Human TRADD Anticorps:
anti-Mouse (Murine) TRADD Anticorps:
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Human Monoclonal TRADD Primary Antibody pour IF, IP - ABIN968046
He, Ting: A20 inhibits tumor necrosis factor (TNF) alpha-induced apoptosis by disrupting recruitment of TRADD and RIP to the TNF receptor 1 complex in Jurkat T cells. dans Molecular and cellular biology 2002
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Human Monoclonal TRADD Primary Antibody pour IF, IP - ABIN968045
Morgan, Thorburn, Pandolfi, Thorburn: Nuclear and cytoplasmic shuttling of TRADD induces apoptosis via different mechanisms. dans The Journal of cell biology 2002
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Human Monoclonal TRADD Primary Antibody pour WB - ABIN967541
Hsu, Shu, Pan, Goeddel: TRADD-TRAF2 and TRADD-FADD interactions define two distinct TNF receptor 1 signal transduction pathways. dans Cell 1996
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Human Polyclonal TRADD Primary Antibody pour IP, IHC - ABIN223257
Chen, Texada, Duggan, Liang, Reden, Kooragayala, Langford: Surface calreticulin mediates muramyl dipeptide-induced apoptosis in RK13 cells. dans The Journal of biological chemistry 2005
Human Polyclonal TRADD Primary Antibody pour IF (p), IHC (p) - ABIN673314
Chen, Zhang, Zhang, Li, Sun: Hydrogen sulfide protects against TNF-α induced neuronal cell apoptosis through miR-485-5p/TRADD signaling. dans Biochemical and biophysical research communications 2016
Human Polyclonal TRADD Primary Antibody pour IHC (p), IHC - ABIN407974
Chakraborty, Li, Tang, Xie, Puliyappadamba, Raisanen, Burma, Boothman, Cochran, Wu, Habib: Cytoplasmic TRADD confers a worse prognosis in glioblastoma. dans Neoplasia (New York, N.Y.) 2013
Human Monoclonal TRADD Primary Antibody pour FACS, WB - ABIN4899051
Kolliputi, Waxman: IL-6 cytoprotection in hyperoxic acute lung injury occurs via suppressor of cytokine signaling-1-induced apoptosis signal-regulating kinase-1 degradation. dans American journal of respiratory cell and molecular biology 2009
These data for the first time identifies miR (Montrer MLXIP Anticorps)-485-5p/TRADD axis in hydrogen sulfide (Montrer SQRDL Anticorps) protecting against TNF-alpha (Montrer TNF Anticorps)-induced neuronal cell apoptosis.
By reducing the levels of TRADD, wild type CFTR suppresses downstream proinflammatory NFkappaB signaling.
NPM (Montrer NPM1 Anticorps)-RAR (Montrer RARA Anticorps) binding to TRADD selectively inhibits caspase (Montrer CASP3 Anticorps) activation, while allowing activation of NFkappaB (Montrer NFKB1 Anticorps) and JNK (Montrer MAPK8 Anticorps)
The release of extracellular vesicles was triggered by TNFA (Montrer TNF Anticorps) from BEAS-2b cells.TNFA-triggered extracellular vesicles contained TNFR1 (Montrer TNFRSF1A Anticorps) and TRADD.
MicroRNA-30c-2-3p negatively regulates NF-kappaB (Montrer NFKB1 Anticorps) signaling and cell cycle progression through downregulation of TRADD and CCNE1 (Montrer CCNE1 Anticorps) in breast cancer.
domains of calmodulin mediate FADD (Montrer FADD Anticorps) and TRADD interaction
PA induced the apoptosis of HUVECs by initiating the death pathway (TNF-R1 (Montrer TNFRSF1A Anticorps)/TRADD/caspases 8 pathway), whereas AA enhanced cell survival to protect vascular endothelial cells by activating the survival pathway (TNF-R1 (Montrer TNFRSF1A Anticorps)/RIP (Montrer HRB Anticorps)/NF-kappaB (Montrer NFKB1 Anticorps) 50/NF-kappaB (Montrer NFKB1 Anticorps) 65).
Biologic assessment found that NPM (Montrer NPM1 Anticorps)-RAR (Montrer RARA Anticorps) expression impaired TNF (Montrer TNF Anticorps)-induced signaling through TRADD, blunting TNF (Montrer TNF Anticorps)-mediated activation of caspase-3 (CASP3 (Montrer CASP3 Anticorps)) and caspase-8 (CASP8 (Montrer CASP8 Anticorps)), to ultimately block apoptosis.
TRADD gene expression was knocked down by an antisense oligonucleotide.
structure-based mutations of TNFR-1 (Montrer TNFRSF1A Anticorps) (P367A and P368A), TRADD (F266A), and RIP1 (Montrer UQCRFS1 Anticorps) (M637A and R638A) disrupted formation of the death domain (DD) complex and prevented stable interactions among those DDs
TRADD knockout blunts pressure overload-induced cardiac hypertrophy through mediating TAK1 (Montrer NR2C2 Anticorps)/p38 MAPK (Montrer MAPK14 Anticorps) but not AKT (Montrer AKT1 Anticorps) phosphorylation
Data indicate that ASK1 (Montrer MAP3K5 Anticorps) activation stimulated the activity of the transcription factor FoxO3a (Montrer FOXO3 Anticorps), which increased the abundance of the apoptosis-promoting adaptor protein TRADD, leading to activation of caspase 8 (Montrer CASP8 Anticorps).
data indicate that TRADD shuttles dynamically from the cytoplasm into the nucleus to modulate the interaction between p19(Arf (Montrer CDKN2A Anticorps)) and its E3 ubiquitin ligase (Montrer MUL1 Anticorps) ULF (Montrer TRIP12 Anticorps), thereby promoting p19(Arf (Montrer CDKN2A Anticorps)) protein stability and tumour suppression
Data suggest that deficiency of TRADD sensitizes cells to TRAIL-induced apoptosis, and that enhanced cell death in TRADD(-/-) MEFs is associated with defective NF-kappaB (Montrer NFKB1 Anticorps) activation.
TRADD is required for recruitment of receptor interacting protein 1 (Montrer RIPK1 Anticorps) and TNFR (Montrer TNFRSF1A Anticorps)-associated factor 2 to the DR3 (Montrer TNFRSF25 Anticorps) signaling complex and for the ubiquitination of receptor interacting protein 1 (Montrer RIPK1 Anticorps)
We show that TRADD is recruited to the TRAIL-receptor complex, and RIP1 (Montrer RALBP1 Anticorps) recruitment is mediated by TRADD.
TRADD may be involved in IFN-gamma (Montrer IFNG Anticorps) signaling by forming a complex with STAT1 (Montrer STAT1 Anticorps)-alpha within the nucleus and regulating IFN-gamma (Montrer IFNG Anticorps)-mediated STAT1 (Montrer STAT1 Anticorps)-alpha activation.
Tradd activates distinct mechanisms of apoptosis from the nucleus and the cytoplasm.
silencing TRADD expression with small-interfering RNA reduced neuronal apoptosis and subsequent microglial and astroglial activation
TRADD is a multifunctional protein crucial both for TNFR1 (Montrer TNFRSF1A Anticorps) signaling and other signaling pathways relevant to immune responses.
TNF (Montrer TNF Anticorps) binding induces release of AIP1 (DAB2IP (Montrer DAB2IP Anticorps)) from TNFR1 (Montrer TNFRSF1A Anticorps), resulting in cytoplasmic translocation and concomitant formation of an intracellular signaling complex comprised of TRADD, RIP1 (Montrer RALBP1 Anticorps), TRAF2 (Montrer TRAF2 Anticorps), and AIPl.
The protein encoded by this gene is a death domain containing adaptor molecule that interacts with TNFRSF1A/TNFR1 and mediates programmed cell death signaling and NF-kappaB activation. This protein binds adaptor protein TRAF2, reduces the recruitment of inhibitor-of-apoptosis proteins (IAPs) by TRAF2, and thus suppresses TRAF2 mediated apoptosis. This protein can also interact with receptor TNFRSF6/FAS and adaptor protein FADD/MORT1, and is involved in the Fas-induced cell death pathway.
TNFRSF1A-associated via death domain
, conjugal transfer protein D
, TNFR1-associated death domain protein
, tumor necrosis factor receptor type 1 associated death domain protein
, tumor necrosis factor receptor type 1-associated DEATH domain protein
, tumor necrosis factor receptor-1-associated protein
, TNF receptor 1 associated signal transducer
, TNFR1-associated DEATH domain protein
, Tumor necrosis factor receptor type 1-associated DEATH domain protein
, TNFRSF1A-associated via death domain protein