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Human TRAF6 Kit ELISA pour Sandwich ELISA - ABIN578203
Bilir, Engin, Can, Temi, Demirtas: The prognostic role of inflammation and hormones in patients with metastatic cancer with cachexia. dans Medical oncology (Northwood, London, England) 2015
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we found that reactive oxygen species-induced autophagy acts as a negative feedback regulator of JNK (Montrer MAPK8 Kits ELISA) activity by dissociating Atg9 (Montrer ATG9A Kits ELISA)/mAtg9 (Montrer ATG9A Kits ELISA) from dTRAF2/TRAF6 in Drosophila.
null mutant of DTRAF2 showed immune deficiencies in which NF-kappaB nuclear translocation and antimicrobial gene transcription against microbial infection were severely impaired
this study shows that TRAF6 is necessary for the nontranscriptional priming of NLRP3 (Montrer NLRP3 Kits ELISA) inflammasome by TLR/IL-1R derived signals
work reveals that simulated microgravity promotes the apoptotic response through a combined modulation of the Uev1A/TICAM/TRAF (Montrer TRAF1 Kits ELISA)/NF-kappaB (Montrer NFKB1 Kits ELISA)-regulated apoptosis and the p53 (Montrer TP53 Kits ELISA)/PCNA (Montrer PCNA Kits ELISA)- and ATM (Montrer ATM Kits ELISA)/ATR (Montrer ATR Kits ELISA)-Chk1 (Montrer CHEK1 Kits ELISA)/2-controlled DNA-damage response pathways.
TRAF6 prevents the mitochondrial translocation of p53 (Montrer TP53 Kits ELISA) and spontaneous apoptosis by promoting lysine63-linked ubiquitination of p53 (Montrer TP53 Kits ELISA) in cytosol.
TRAF6 mediates lysine-63 ubiquitination within the SH2 domain of STAT3 (Montrer STAT3 Kits ELISA), which is an essential step for STAT3 (Montrer STAT3 Kits ELISA) membrane recruitment and phosphorylation in response to S Typhimurium infection; results reveal a strategy in which S Typhimurium T3SS effectors broaden their functions through the activation of host proteins in a ubiquitination-dependent manner to manipulate host cells into becoming a Salmonella-friendly zone
this study shows that an interaction of TRAF6 with cullin-5 (Montrer CUL5 Kits ELISA) promotes TRAF6 polyubiquitination and lipopolysaccharide signaling
Consistent with cellular studies, icaritin downregulated TRAF6 and NFATc1 protein expression in CD11b(+) /Gr-1(-/low) osteoclast precursors
Data (including data from studies using knockout mice) suggest that RANKL (Montrer TNFSF11 Kits ELISA) enhances TNF (Montrer TNF Kits ELISA)-induced osteoclast formation from precursor spleen cells and enhances bone resorption independently of Traf6 by degrading Traf3 (Montrer TRAF3 Kits ELISA), a known inhibitor of osteoclastogenesis. (RANKL (Montrer TNFSF11 Kits ELISA) = osteoclast differentiation factor (Montrer TNFSF11 Kits ELISA); TNF (Montrer TNF Kits ELISA) = tumor necrosis factor (Montrer TNF Kits ELISA); Traf (Montrer TRAF1 Kits ELISA) = TNF (Montrer TNF Kits ELISA) receptor-associated factor)
the SH3 domain (Montrer ITSN1 Kits ELISA) of NOSTRIN (Montrer NOSTRIN Kits ELISA) is involved in the NOSTRIN (Montrer NOSTRIN Kits ELISA)-TRAF6 interaction and is required for NOSTRIN (Montrer NOSTRIN Kits ELISA)-induced down-regulation of endothelial cell proteins
this study shows that TRAF6 overexpression in hematopoietic stem/progenitor cells results in impaired hematopoiesis and bone marrow failure
TRAF6 and H2AX (Montrer H2AFX Kits ELISA) overexpression and gammaH2AX (Montrer H2AFX Kits ELISA)-mediated HIF1alpha (Montrer HIF1A Kits ELISA) enrichment in the nucleus of cancer cells lead to overactivation of HIF1alpha (Montrer HIF1A Kits ELISA)-driven tumorigenesis, glycolysis and metastasis.
we have now analyzed the in vivo function of Traf6 in the innate immune response without interference of adaptive immunity
Full-length traf6 was functionally characterized.
Taken together, these results define a novel role for miR (Montrer MLXIP Kits ELISA)-146a as a negative regulator of dengue virus-induced autophagy and identify TRAF6 as a key target of this microRNA in modulating the dengue virus-autophagy interaction.
These data define that YOD1 (Montrer YOD1 Kits ELISA) antagonizes TRAF6/p62 (Montrer GTF2H1 Kits ELISA)-dependent IL-1 (Montrer IL1A Kits ELISA) signaling to NF-kappaB (Montrer NFKB1 Kits ELISA).
high expression of TRAF6 is significant for esophageal cancer progression, and TRAF6 indicates poor prognosis in esophageal cancer patients.
CRBN (Montrer CRBN Kits ELISA) negatively regulates TLR4 (Montrer TLR4 Kits ELISA) signaling via attenuation of TRAF6 and TAB2 (Montrer TAB2 Kits ELISA) ubiquitination.
the polymorphisms in TLR-MyD88 (Montrer MYD88 Kits ELISA)-NF-kappaB (Montrer NFKB1 Kits ELISA) signaling pathway confer genetic susceptibility to Type 2 diabetes mellitus and diabetic nephropathy.
The E3 ligase TRAF6 binds to DCP1a (Montrer DCP1A Kits ELISA) and indirectly regulates DCP1a (Montrer DCP1A Kits ELISA) phosphorylation, expression of decapping factors, and gene-specific mRNA decay.
Study showed that patients without a history of atrial fibrillation who develop postoperative atrial fibrillation have a higher percentage of left atrial fibrosis, increased expression of TRAF6, higher serum Ang II (Montrer AGT Kits ELISA) levels, and changes in the activities of the MAPKs/TGF-beta1 (Montrer TGFB1 Kits ELISA)/TRAF6 pathway.
Low TRAF6 expression is associated with graft-versus-host disease.
The protein encoded by this gene is a member of the TNF receptor associated factor (TRAF) protein family. TRAF proteins are associated with, and mediate signal transduction from, members of the TNF receptor superfamily. This protein mediates signaling from members of the TNF receptor superfamily as well as the Toll/IL-1 family. Signals from receptors such as CD40, TNFSF11/RANCE and IL-1 have been shown to be mediated by this protein. This protein also interacts with various protein kinases including IRAK1/IRAK, SRC and PKCzeta, which provides a link between distinct signaling pathways. This protein functions as a signal transducer in the NF-kappaB pathway that activates IkappaB kinase (IKK) in response to proinflammatory cytokines. The interaction of this protein with UBE2N/UBC13, and UBE2V1/UEV1A, which are ubiquitin conjugating enzymes catalyzing the formation of polyubiquitin chains, has been found to be required for IKK activation by this protein. This protein also interacts with the transforming growth factor (TGF) beta receptor complex and is required for Smad-independent activation of the JNK and p38 kinases. This protein has an amino terminal RING domain which is followed by four zinc-finger motifs, a central coiled-coil region and a highly conserved carboxyl terminal domain, known as the TRAF-C domain. Two alternatively spliced transcript variants, encoding an identical protein, have been reported.
TNF receptor-associated factor 6-B
, E3 ubiquitin-protein ligase TRAF6
, TNF-receptor-associated factor 2
, TNF receptor-associated factor 6
, TNF receptor-associated factor 6-like
, RING finger protein 85
, interleukin-1 signal transducer
, TNF-receptor associated factor 6