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anti-Mouse (Murine) ADAM17 Anticorps:
anti-Human ADAM17 Anticorps:
anti-Rat (Rattus) ADAM17 Anticorps:
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Human Monoclonal ADAM17 Primary Antibody pour CyTOF, FACS - ABIN4900517
Zingoni, Cecere, Vulpis, Fionda, Molfetta, Soriani, Petrucci, Ricciardi, Fuerst, Amendola, Mytilineos, Cerboni, Paolini, Cippitelli, Santoni: Genotoxic Stress Induces Senescence-Associated ADAM10-Dependent Release of NKG2D MIC Ligands in Multiple Myeloma Cells. dans Journal of immunology (Baltimore, Md. : 1950) 2015
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Human Monoclonal ADAM17 Primary Antibody pour CyTOF, FACS - ABIN4900516
Breshears, Schlievert, Peterson: A disintegrin and metalloproteinase 17 (ADAM17) and epidermal growth factor receptor (EGFR) signaling drive the epithelial response to Staphylococcus aureus toxic shock syndrome toxin-1 (TSST-1). dans The Journal of biological chemistry 2012
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Human Monoclonal ADAM17 Primary Antibody pour FACS - ABIN4897862
Kermarrec, Selloum, Plantefeve, Chosidow, Paoletti, Lopez, Mantz, Desmonts, Gougerot-Pocidalo, Chollet-Martin: Regulation of peritoneal and systemic neutrophil-derived tumor necrosis factor-alpha release in patients with severe peritonitis: role of tumor necrosis factor-alpha converting enzyme cleavage. dans Critical care medicine 2005
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Human Polyclonal ADAM17 Primary Antibody pour IHC - ABIN965510
Rabie, Strehl, Ludwig, Nieswandt: Evidence for a role of ADAM17 (TACE) in the regulation of platelet glycoprotein V. dans The Journal of biological chemistry 2005
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Human Monoclonal ADAM17 Primary Antibody pour FACS - ABIN4897863
Moreira-Tabaka, Peluso, Vonesch, Hentsch, Kessler, Reimund, Dumont, Muller: Unlike for human monocytes after LPS activation, release of TNF-α by THP-1 cells is produced by a TACE catalytically different from constitutive TACE. dans PLoS ONE 2012
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Human Polyclonal ADAM17 Primary Antibody pour ICC, ELISA - ABIN1003300
Moss, Jin, Milla, Bickett, Burkhart, Carter, Chen, Clay, Didsbury, Hassler, Hoffman, Kost, Lambert, Leesnitzer, McCauley, McGeehan, Mitchell, Moyer, Pahel, Rocque, Overton, Schoenen, Seaton, Su et al.: Cloning of a disintegrin metalloproteinase that processes precursor tumour-necrosis factor-alpha. ... dans Nature 1997
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Human Monoclonal ADAM17 Primary Antibody pour IHC (p), PLA - ABIN563080
Kahlert, Weber, Mogler, Bergmann, Schirmacher, Kenngott, Matterne, Mollberg, Rahbari, Hinz, Koch, Aigner, Weitz: Increased expression of ALCAM/CD166 in pancreatic cancer is an independent prognostic marker for poor survival and early tumour relapse. dans British journal of cancer 2009
Human Polyclonal ADAM17 Primary Antibody pour ICC, ELISA - ABIN1003301
Rosendahl, Ko, Long, Brewer, Rosenzweig, Hedl, Anderson, Pyle, Moreland, Meyers, Kohno, Lyons, Lichenstein: Identification and characterization of a pro-tumor necrosis factor-alpha-processing enzyme from the ADAM family of zinc metalloproteases. dans The Journal of biological chemistry 1997
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Human Polyclonal ADAM17 Primary Antibody pour ICC, FACS - ABIN1030720
McGowan, Mullooly, Caiazza, Sukor, Madden, Maguire, Pierce, McDermott, Crown, ODonovan, Duffy: ADAM-17: a novel therapeutic target for triple negative breast cancer. dans Annals of oncology : official journal of the European Society for Medical Oncology / ESMO 2013
Chicken Polyclonal ADAM17 Primary Antibody pour ELISA, WB - ABIN2478641
Umetsu, Yamashita, Suzuki: Purification and carbohydrate-binding specificities of a blood type B binding lectin from hemolymph of a crab (Charybdis japonica). dans Journal of biochemistry 1991
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most defects in formation of the postnatal epidermal barrier upon keratinocyte-specific ADAM17 deletion are mediated via EGFR (Montrer EGFR Anticorps)
ADAM17 is either not required in T cells under homoeostatic conditions and for control of listeria infection or can be effectively compensated by other mechanisms
In a clinically relevant CADASIL (Montrer NOTCH3 Anticorps) mouse model, we show that exogenous ADAM17 or HB-EGF (Montrer HBEGF Anticorps) restores cerebral arterial tone and blood flow responses, and identify upregulated voltage-dependent potassium channel (Montrer KCNAB2 Anticorps) (KV) number in cerebral arterial myocytes as a heretofore-unrecognized downstream effector of TIMP3 (Montrer TIMP3 Anticorps)-induced deficits.
Conditional ADAM17 knockout mice lacking ADAM17 in all leukocytes had a significant survival advantage during severe polymicrobial sepsis induced by CLP, associated with enhanced neutrophil recruitment at the infectious locus along with decreased bacterial spread and circulating levels of proinflammatory factors. Its induction during sepsis may tip the balance between efficient and impaired neutrophil recruitment.
These results demonstrate a novel physiologic role for a disintegrin and metalloprotease 17 in regulating murine IL-6 (Montrer IL6 Anticorps) signals during inflammatory processes.
These results show that TACE is a target of, and is downregulated by, soluble TNF (Montrer TNF Anticorps)-induced AP-2alpha (Montrer TFAP2A Anticorps) transcription factor in dendritic cells
the critical role of the transmembrane domains of ADAM17 and Rhbdf2 (Montrer RHBDF2 Anticorps) in the regulation of the ADAM17 and EGFR (Montrer EGFR Anticorps), and ADAM17 and TNFalpha (Montrer TNF Anticorps) signaling pathways, was examined.
Findings provide evidence that ADAM10 (Montrer ADAM10 Anticorps), and not ADAM17, is indispensable for proper retinal development as a regulator of NOTCH (Montrer NOTCH1 Anticorps) signaling.
this study shows that the iRhom2 (Montrer RHBDF2 Anticorps)/ADAM17 pathway plays an important role in regulating CSF1R (Montrer CSF1R Anticorps) expression in the myeloid cell compartment at steady state, and in modulating development of monocytes/macrophages during their repopulation
Suggest an atheroprotective role of ADAM17, which might be mediated by cleaving membrane-bound TNFalpha (Montrer TNF Anticorps) and TNFR2 (Montrer TNFRSF1B Anticorps), thereby preventing overactivation of endogenous TNFR2 (Montrer TNFRSF1B Anticorps) signaling in cells of the vasculature.
the chaperone 78-kDa glucose-regulated protein (GRP78 (Montrer HSPA5 Anticorps)) protects the MPD (Montrer MVD Anticorps) against PDI (Montrer PADI1 Anticorps)-dependent disulfide-bond isomerization by binding to this domain and, thereby, preventing ADAM17 inhibition.
The ADAM17 messenger RNA (mRNA) and protein levels were significantly higher in the inferior turbinate than in nasal polyps (p < 0.05). The ADAM10 (Montrer ADAM10 Anticorps) mRNA and protein levels did not differ significantly between NPs (Montrer NPS Anticorps) and inferior turbinates (p > 0.05). ADAM10 (Montrer ADAM10 Anticorps) and ADAM17 were expressed primarily in inflammatory cells, submucosal glandular cells, and lining epithelial cells.
The iRhom2 (Montrer RHBDF2 Anticorps) N-terminus stabilizes mature ADAM17 at the cell surface where it cleaves TNF (Montrer TNF Anticorps) and EGFR (Montrer EGFR Anticorps) in inflammatory and innate immune responses. (Review)
inhibition of ADAM17 enhanced the purity of expanded NK cells and the antibody-dependent cellular cytotoxicity activity of these cells against trastuzumab treated breast cancer cell lines.
hypoxia instigates the RSK1 (Montrer RPS6KA1 Anticorps)-dependent C/EBPbeta (Montrer CEBPB Anticorps) signaling pathway, which in turn initiates binding of C/EBPbeta (Montrer CEBPB Anticorps) to the ADAM 17 promoter and ultimately induces ADAM 17 expression in human lung fibroblasts.
TNF-alpha-converting enzyme -mediated cleavage of soluble RANKL (Montrer TNFSF11 Anticorps) from activated lymphocytes, especially B cells, can promote osteoclastogenesis in periodontitis.
Cell stimulation can downregulate expression of mature ADAM17 from the cell surface and induce release of exosomal ADAM17, which can then distribute and contribute to substrate shedding on more distant cells.
Aging and obesity cooperatively reduce caveolin-1 (Montrer CAV1 Anticorps) expression and increase vascular endothelial ADAM17 activity and soluble TNF (Montrer TNF Anticorps) release in adipose tissue, which may contribute to the development of remote coronary microvascular dysfunction in older obese patients.
Our data demonstrated that elevated serum Semaphorin5A (Sema5A (Montrer SEMA5A Anticorps)) in SLE patients correlated with disease activity and are involved in kidney and blood system damage; ADAM17 might be involved in the release of secreted Sema5A (Montrer SEMA5A Anticorps).
ADAM17 and ADAM10 (Montrer ADAM10 Anticorps) cleave Nectin-4 (Montrer PVRL4 Anticorps) and release soluble Nectin-4 (Montrer PVRL4 Anticorps) (sN4).
ADAM17 was involved in porcine CD16 (Montrer CD16 Anticorps) shedding in porcine reproductive and respiratory syndrome virus-infected pigs.
Overexpression of ADAM17 induced downregulation of CD163 (Montrer CD163 Anticorps) expression and a reduction in reproductive and respiratory syndrome virus infection.
activation of TACE/ADAM17 via a PKC (Montrer FYN Anticorps)-induced c-Src (Montrer SRC Anticorps)-dependent manner mediates proteolytic activation of the EGF (Montrer EGF Anticorps)-like factors that are involved in the induction of granulosa cell differentiation, cumulus expansion, and meiotic maturation of porcine oocytes
Data indicate that TNF-alpha (Montrer TNF Anticorps) stimulates Rac (Montrer AKT1 Anticorps), ADAM17/TACE, and RhoA (Montrer RHOA Anticorps) through the guanine nucleotide exchange factor (Montrer ARHGEF12 Anticorps) (GEF)-H1 (Montrer ARHGEF2 Anticorps).
progesterone-induced TACE/ADAM17 leads to production of soluble EGF (Montrer EGF Anticorps) domain from cumulus cells, which enhances functional changes of cumulus cells and progresses meiotic maturation of oocytes
This gene encodes a member of the ADAM (a disintegrin and metalloprotease domain) family. Members of this family are membrane-anchored proteins structurally related to snake venom disintegrins, and have been implicated in a variety of biologic processes involving cell-cell and cell-matrix interactions, including fertilization, muscle development, and neurogenesis. The protein encoded by this gene functions as a tumor necrosis factor-alpha converting enzyme\; binds mitotic arrest deficient 2 protein\; and also plays a prominent role in the activation of the Notch signaling pathway.
ADAM metallopeptidase domain 17 (tumor necrosis factor, alpha, converting enzyme)
, a disintegrin and metalloproteinase domain 17 (tumor necrosis factor, alpha, converting enzyme)
, disintegrin and metalloproteinase domain-containing protein 17
, tumor necrosis factor alpha converting enzyme
, a disintegrin and metallopeptidase domain 17
, ADAM metallopeptidase domain 17
, a disintegrin and metalloprotease domain 17
, disintegrin metalloproteinase
, disintegrin and metalloproteinase domain-containing protein 17-like
, ADAM 17
, TNF-alpha convertase
, TNF-alpha converting enzyme
, TNF-alpha-converting enzyme
, a disintegrin and metalloprotease domain 17; TNF-alpha converting enzyme
, a disintegrin and metalloproteinase domain 17
, ADAM metallopeptidase domain 18
, snake venom-like protease
, tumor necrosis factor, alpha, converting enzyme