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we report for the first time that CRB3 acts as an upstream regulator of the Hippo pathway to regulate contact inhibition by recruiting other Hippo molecules, such as Kibra (Montrer WWC1 Kits ELISA) and/or FRMD6 (Montrer FRMD6 Kits ELISA), in mammary epithelial cells.
CRB3A recruits p114RhoGEF (Montrer ARHGEF18 Kits ELISA) and its activator Ehm2 to the cell periphery using both functional motifs of its cytoplasmic tail and increases RhoA (Montrer RHOA Kits ELISA) activation levels.
our data demonstrated that CRB3 may be used as a new independent favorable prognostic factor for human ccRCC
Morg1 (Montrer wdr83 Kits ELISA) facilitates Par6 (Montrer PARD6A Kits ELISA)-aPKC binding to Crb3 for definition of apical identity of epithelial cells.
the Crumbs3-Pals1 (Montrer MPP5 Kits ELISA) complex has a role in development of polarity in mammalian epithelial cells
CRB3, through its cytoplasmic domain and its interactors, plays a role in apical membrane morphogenesis and tight junction regulation.
Data show that a novel Crumbs3 isoform regulates cell division and ciliogenesis via importin beta1 interactions.
overexpression of human CRB1 (Montrer CRB1 Kits ELISA) and related isoforms, CRB2 and CRB3, had no effect on the levels of presenilin complex components, on NCT (Montrer NCSTN Kits ELISA) maturation or on PS endoproteolysis
Crb3, a Crumbs isoform that determines epithelial apical domain identity, is required for airway differentiation by controlling the localization of the transcriptional regulator Yap (Montrer YAP1 Kits ELISA).
The presence of Crb3 in many organs and the regularity of Crb3 distribution in the process of mouse embryonic development indicate that Crb3 protein plays an important role in establishing and maintaining the polarity of mouse embryos.
Data indicate that Crb3 (Crumbs3) is crucial for epithelial morphogenesis and plays a role in linking the apical membrane to the underlying ezrin (Montrer EZR Kits ELISA)-containing cytoskeleton.
the presence of CRB3 protein in the mouse retina
Data show the deletion of Pals1 (Montrer MPP5 Kits ELISA) leads to the disruption of the apical localization of Crb polarity complex proteins Crb1 (Montrer CRB1 Kits ELISA), Crb2 and Crb3 in retinal progenitors and the adult retina.
This gene encodes a member of the Crumbs family of proteins. This protein may play a role in epithelial cell polarity and is associated with tight junctions at the apical surface of epithelial cells. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.
crumbs protein homolog 3
, protein crumbs homolog 3