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BCL6 (Montrer BCL6 Kits ELISA) inhibits transcription by competing for the Notch1 (Montrer NOTCH1 Kits ELISA) intracellular domain, preventing the coactivator Mastermind-like1 (MAM1) from binding.
XMam1 has the ability to induce the cell fate into the neurogenic lineage in a Notch (Montrer NOTCH1 Kits ELISA)-independent manner
Similar phenotypes were observed by conditionally misexpressing a dominant negative form of MAML1 in Mitral cells ( MCs (Montrer SMCP Kits ELISA))after their migration. Furthermore, the intracellular domain of Notch1 (Montrer NOTCH1 Kits ELISA) (NICD1) was localized to nuclei of MCs (Montrer SMCP Kits ELISA). These findings suggest that Notch (Montrer NOTCH1 Kits ELISA) signaling at embryonic stages is involved in the dendritic complexity of MCs (Montrer SMCP Kits ELISA)
These observations suggest that chondrocyte maturation was impaired in MAML1(-/-) mice. MAML1 enhances the transcriptional activity of Runx2 (Montrer RUNX2 Kits ELISA) and plays a role in bone development.
This study demonstrated that targeting Maml1-induced tumor cell senescence and differentiation may alter the tumor microenvironment and cytokine and chemokine (Montrer CCL1 Kits ELISA) profiles and may also promote innate and adaptive immune cell infiltration and function.
Maml-mediated Notch (Montrer NOTCH1 Kits ELISA) signaling plays a pivotal role in the initiation and maintenance of goblet cell differentiation for normal ocular surface morphogenesis.
Mastermind-like 1 (MamL1) and mastermind-like 3 (MamL3) are essential for Notch signaling in vivo.
Data demonstrate that Mesp2 (Montrer Mesp2 Kits ELISA) potently represses Notch (Montrer NOTCH1 Kits ELISA) signaling by inducing the destabilization of mastermind-like 1, a core regulator of this pathway.
MAML1 is a novel modulator for NF-kappaB (Montrer NFKB1 Kits ELISA) signaling and regulates cellular survival.
There seems to be close correlation of the spatial and temporal expression of Maml1, in the central nervous system (CNS) during early development, implicating a role for the Maml1 gene in neurogenesis.
a dominant negative mutant of MAML1 resulted in early inhibition of T-cell development and the appearance of intrathymic B cells, phenotypes consistent with Notch1 (Montrer NOTCH1 Kits ELISA) inhibition
MAML1 acts as a coactivator for MEF2C (Montrer MEF2C Kits ELISA) transcription and is essential for proper muscle development
Authors report that p300 (Montrer EP300 Kits ELISA) and CBP (Montrer CREBBP Kits ELISA) acetylate Mastermind-like 1 (Maml1) on amino acid residues K188 and K189 to recruit NACK to the Notch1 (Montrer NOTCH1 Kits ELISA) ternary complex, which results in the recruitment of RNA polymerase II to initiate transcription.
MAML1 may play an important role in tumor progression of Hepatocellular Carcinoma.
Notch (Montrer NOTCH1 Kits ELISA) signaling was altered in almost half of the clear-cell renal cell carcinoma patients and copy number variances in MAML1 and KAT2B (Montrer KAT2B Kits ELISA) were predominant changes.
The transcriptional coregulator MAML1 affects DNA methylation (Montrer HELLS Kits ELISA) and gene expression patterns in human embryonic kidney cells.
study identifies that MAML1 is ubiquitinated in the absence of Notch (Montrer NOTCH1 Kits ELISA) signaling to maintain low levels of MAML1 in the cell
In MCF-7 cells p53 (Montrer TP53 Kits ELISA) associates with the Notch (Montrer NOTCH1 Kits ELISA) transcriptional complex (NTC) in a MAML1-dependent fashion, most likely through a p53 (Montrer TP53 Kits ELISA)-MAML1 interaction.
The impact of MAML1 genetic variants to heart rate was discovered.
Data indicate that EpCAM (Montrer EPCAM Kits ELISA), CK19 (Montrer KRT19 Kits ELISA), and hMAM triple-marker-positive circulating tumor cells (CTCs) were detected in 86 of 98 (87.8 %) patients.
Snail (Montrer SNAI1 Kits ELISA) decreased transcription of Notch1 (Montrer NOTCH1 Kits ELISA) intracellular domain (NICD (Montrer NOTCH1 Kits ELISA)) target genes via competing with MAML1, co-activator, in NICD (Montrer NOTCH1 Kits ELISA) complex.
Authors report that human papillomavirus type 8 E6 subverts NOTCH (Montrer NOTCH1 Kits ELISA) activation during keratinocyte differentiation by inhibiting RBPJ (Montrer RBPJ Kits ELISA)/MAML1 transcriptional activator complexes at NOTCH (Montrer NOTCH1 Kits ELISA) target DNA.
This protein is the human homolog of mastermind, a Drosophila protein that plays a role in the Notch signaling pathway involved in cell-fate determination. There is in vitro evidence that the human homolog forms a complex with the intracellular portion of human Notch receptors and can increase expression of a Notch-induced gene. This evidence supports its proposed function as a transcriptional co-activator in the Notch signaling pathway.
, mastermind-like 1
, mastermind-like protein 1
, mastermind homolog