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polyglutamine-induced cell death was dramatically suppressed in flies lacking Dark, the fly homolog of human Apaf-1, a key regulator of apoptosis
structural analysis of Apaf-1 in the auto-inhibited form demonstrates the critical role of ADP [review]
ARK is essential for apoptosis during D. melanogaster development, and for radiation-induced apoptosis. Ark mutant embryos have extra cells, and tissues such as brain lobes and wing discs are enlarged.
Daxx (Montrer DAXX Kits ELISA)-like protein of Drosophila interacts with Dmp53 and affects longevity and Ark mRNA level
Loss of APAF-1 expression is associated with early recurrence in stage I-III colorectal cancer, suggesting that APAF-1 may have clinical value as a predictive marker of early recurrence.
the markers Ets-1 and APAF-1 relative to p53, Ki-67 and PTEN expression in colon adenomas/polyps, were investigated.
Different selenium concentrations had varying effects on BAK1 (Montrer BAK1 Kits ELISA) and APAF1 levels. APAF1 may play an important role in the pathogenesis of KBD
miR21 is transferred from cancer-associated adipocytes (CAAs) and fibroblasts (CAFs (Montrer TBX1 Kits ELISA)) to the cancer cells, where it suppresses ovarian cancer apoptosis and confers chemoresistance by binding to its direct novel target, APAF1.
HDAC (Montrer HDAC3 Kits ELISA) inhibitors can induce p53 (Montrer TP53 Kits ELISA) acetylation at lysine 120, which in turn enhances mitochondrion-mediated apoptosis through transcriptional up-regulation of Apaf-1.
Renal APAF1 expression is increased in diabetes and diabetic nephropathy.
Inhibition of Caspase-9 restricted, while Apaf-1 promoted, Chlamydia pneumoniae infection in HEp-2, HeLa, and mouse epithelial fibroblast (MEF) cells.
These results suggest that CED-4 forms a complex with ced-3 mRNA and delivers it to ribosomes for translation.
The auto-assembly of truncated Apaf1 molecules disappeared after several hours without any enzyme activation.
cytochrome c (Montrer CYCS Kits ELISA) and the WD domains of Apaf-1 interact, with bifurcated salt bridges involved in apoptosome assembly
miR (Montrer MLXIP Kits ELISA)-183 was induced in protective postconditioning and reduced reperfusion injury of the livers via the targeting of apoptotic signaling. miR (Montrer MLXIP Kits ELISA)-183 mediated the tolerance induced by iPoC in livers via Apaf-1 repressing.
Apaf1's pivotal role during embryonic development as has been demonstrated to be in regulation of neuronal cell death
Apaf1 is required for proper cortical neuron differentiation since its deletion specifically impairs axonal outgrowth.
study demonstrates that MMP-3 (Montrer MMP3 Kits ELISA) leads to caspase-9 (Montrer CASP9 Kits ELISA) activation and suggests that this occurs indirectly via a cytosolic protein, possibly involving Apaf-1
results provide evidence that Apaf-1 pharmacological inhibition has therapeutic potential for the treatment of apoptosis-related diseases.
Study reports experimental evidence suggesting the likely participation of the Apaf1 protein in the aggregation of polyQ stretches; Apaf1 may enhance polyglutamine aggregation by reducing the cellular protein levels of available functional Hsp70 (Montrer HSP70 Kits ELISA)
miR (Montrer MLXIP Kits ELISA)-23a/b and miR (Montrer MLXIP Kits ELISA)-27a/b are endogenous inhibitory factors of Apaf-1 expression and regulate the sensitivity of neurons to apoptosis.
a role for Apaf1 at the mitochondria
The Apaf-1-independent caspase (Montrer CASP3 Kits ELISA) activation was not inhibited by Bcl-2 (Montrer BCL2 Kits ELISA), and occurred without the release of cytochrome c (Montrer CYCS Kits ELISA) from mitochondria, suggesting that the mitochondrial pathway was not involved in this death process.
Counterpulsation could protect vascular endothelial cells from apoptosis, delaying early atherosclerotic lesions possibly through transcriptional down-regulation of pro-apoptotic gene Apaf-1, and up-regulation of anti-apoptotic gene BIRC2 (Montrer BIRC2 Kits ELISA).
This gene encodes a cytoplasmic protein that initiates apoptosis. This protein contains several copies of the WD-40 domain, a caspase recruitment domain (CARD), and an ATPase domain (NB-ARC). Upon binding cytochrome c and dATP, this protein forms an oligomeric apoptosome. The apoptosome binds and cleaves caspase 9 preproprotein, releasing its mature, activated form. Activated caspase 9 stimulates the subsequent caspase cascade that commits the cell to apoptosis. Alternative splicing results in several transcript variants encoding different isoforms.
, Apaf-1 related killer
, Apaf-1-related killer
, apaf1-related killer
, drosophila Apaf-1-related killer
, lethal (2) SH0173
, transcription unit 1
, apoptotic peptidase activating factor 1
, apoptotic protease-activating factor 1-like
, apoptotic protease-activating factor 1
, apoptotic protease activating factor 1
, forebrain overgrowth