Aperçu des produits pour CHEK1 Protéines (CHEK1)

Full name:
Checkpoint Kinase 1 Protéines (CHEK1)
Chez www.anticorps-enligne.fr sont 21 Checkpoint Kinase 1 (CHEK1) Protéines de 10 de différents fournisseurs disponibles. De plus, nous expédions CHEK1 Anticorps (488) et CHEK1 Kits (26) et beaucoup plus de produits pour cette protéine. Un total de 575 CHEK1 produits sont actuellement listés.
Synonymes:
An08g10320, AO090003000441, C85740, CHEK1, Chk1, id:ibd2720, rad27, zgc:56093
afficher tous les protéines Gène GeneID UniProt
CHEK1 1111 O14757
CHEK1 12649 O35280
CHEK1 140583 Q91ZN7

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CHEK1 Protéines (CHEK1) par origine

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CHEK1 Protéines mieux référencés

  1. Human CHEK1 Protein expressed in Baculovirus infected Insect Cells - ABIN457519 : Larsen, Rampalli, Burns, Brunette, Dilworth, Megeney: Caspase 3/caspase-activated DNase promote cell differentiation by inducing DNA strand breaks. dans Proceedings of the National Academy of Sciences of the United States of America 2010 (PubMed)

Plus protéines pour CHEK1 partenaires d'interaction

Human Checkpoint Kinase 1 (CHEK1) interaction partners

  1. The findings reveal ATXN3 (Montrer ATXN3 Protéines) to be a novel deubiquitinase of Chk1, providing a new mechanism of Chk1 stabilization in genome integrity maintenance.

  2. Small molecule ATR (Montrer ANTXR1 Protéines) and Chk1 inhibitors potently sensitize lymphoma cells to UVA radiation and induce a prominent apoptotic response

  3. These findings demonstrate an unsuspected requirement for a balanced nucleotide pool for optimal Chk1 activation both in unchallenged cells and in response to genotoxic stress.

  4. ATR (Montrer ANTXR1 Protéines) inhibition potentiated Chk1 inhibitor induced replication stress and cytotoxicity via the abrogation of ATR (Montrer ANTXR1 Protéines)-dependent feedback activation of Chk1 induced by Chk1 inhibitor generated replication stress in tumor cell lines.

  5. CHK1 overexpression is associated with T-cell and Hodgkin Lymphoma.

  6. Date show that when Wee1 (Montrer WEE1 Protéines) alone is inhibited, Chk1 suppresses CDC45 (Montrer CDC45 Protéines) loading and thereby limits the extent of unscheduled replication initiation and subsequent S-phase DNA damage, despite very high CDK (Montrer CDK4 Protéines)-activity.

  7. HPV31 regulates RRM2 (Montrer RRM2 Protéines) levels through expression of E7 and activation of the ATR (Montrer ANTXR1 Protéines)-Chk1-E2F1 (Montrer E2F1 Protéines) DNA damage response, which is essential to combat replication stress upon entry into S-phase.

  8. disruption of IGF-1R signaling with small-molecule inhibitors or IGF-1 withdrawal partially abrogates both the phosphorylation and activation of CHK1 by ATR and the accompanying inhibition of chromosomal DNA synthesis in UVB-irradiated keratinocytes.

  9. revealed more than 170 NFAT (Montrer NFATC1 Protéines)-associated proteins, half of which are involved in transcriptional regulation. Among them are many hitherto unknown interaction partners of NFATc1 (Montrer NFATC1 Protéines) and NFATc2 (Montrer NFAT1 Protéines) in T cells, such as Raptor (Montrer RPTOR Protéines), CHEK1, CREB1 (Montrer CREB1 Protéines), RUNX1 (Montrer RUNX1 Protéines), SATB1 (Montrer SATB1 Protéines), Ikaros (Montrer IKZF1 Protéines), and Helios (Montrer ZNFN1A2 Protéines).

  10. Checkpoint kinase 1 and 2 signaling is important for apoptin regulation.

Xenopus laevis Checkpoint Kinase 1 (CHEK1) interaction partners

  1. The study analyzes the role of Chk1 in the replication program in sperm nuclei replicating in Xenopus egg extracts by a combination of experimental and modelling approaches.

  2. ATR-Chk1 DDR pathway appears to be dispensable for the preferential association of REV1 to MMC-damaged chromatin.

  3. Results show that Chk1 negatively regulates the Treslin-mediated loading of Cdc45 (Montrer CDC45 Protéines) onto chromatin and thereby serves to antagonize the initiation of replication.

  4. The MRN complex, in particular the nuclease (Montrer DCLRE1C Protéines) activity of Mre11 (Montrer MRE11A Protéines), plays an important role in the activation of Chk1 in response to stalled replication forks.

  5. DNA polymerase kappa (Montrer POLK Protéines)-dependent DNA synthesis at stalled replication forks is important for CHK1 activation.

  6. APE2 (Montrer APEX2 Protéines) associates with Chk1; a serine residue (S86) in the Chk1-binding motif of APE2 (Montrer APEX2 Protéines) is essential for Chk1 phosphorylation, indicating a Claspin-like but distinct role for APE2 (Montrer APEX2 Protéines) in ATR-Chk1 signaling.

  7. Data show that the death pathway is independent of ERK (Montrer MAPK1 Protéines) but relies on activating Bad phosphorylation through the control of both kinases Cdk1 (Montrer CDK1 Protéines) and JNK (Montrer MAPK8 Protéines).

  8. Findings reveal that XH2AX has a specific role in anterior neural formation of Xenopus, which is mediated through phosphorylation of XH2AX at Thr (Montrer TRH Protéines)(16) by Chk1.

  9. mechanism of Chk1 activation at the DNA replication checkpoint

  10. Cdc25A (Montrer CDC25A Protéines) is essential for the Chk1-induced cell cycle arrest and the DNA replication checkpoint in early embryos

Mouse (Murine) Checkpoint Kinase 1 (CHEK1) interaction partners

  1. work reveals that simulated microgravity promotes the apoptotic response through a combined modulation of the Uev1A/TICAM/TRAF (Montrer TRAF1 Protéines)/NF-kappaB (Montrer NFKB1 Protéines)-regulated apoptosis and the p53 (Montrer TP53 Protéines)/PCNA (Montrer PCNA Protéines)- and ATM (Montrer ATM Protéines)/ATR-Chk1/2-controlled DNA-damage response pathways.

  2. Chk1(-/-) MEFs exhibited the absence of double-strand breaks, yet cells showed delayed DNA damage recovery with pan-nuclear immunostaining pattern of Histone H2AX.

  3. RAD9 (Montrer RAD9A Protéines) has a prominent role in the ATR-Chk1 pathway that is necessary for successful formation of the damage-sensing complex and DNA damage checkpoint signaling.

  4. Acute inactivation of E4F1 (Montrer E4F1 Protéines) in these cells results in CHK1-dependent checkpoint deficiency and multiple mitochondrial dysfunctions that lead to increased ROS (Montrer ROS1 Protéines) production, energy stress, and inhibition of de novo pyrimidine synthesis

  5. Altogether, our results classify E4F1 (Montrer E4F1 Protéines) as a master regulator of CHK1 activity that ensures high fidelity of DNA replication, thus safeguarding genome stability.

  6. Heterozygous loss of Chk1 in a Wnt (Montrer WNT2 Protéines)-driven background resulted in an increase in DNA damage and apoptosis and accelerated both tumour development and progression.

  7. PAR, supplied by PARP1, interacts with Chk1 via a novel PAR-binding regulatory (PbR) motif in Chk1, independent of ATR and its activity

  8. ATM (Montrer ATM Protéines) (pSer-1981)-Chk1 (pSer-345) cascade might have mediated G2/M cell cycle arrest to allowed time to facilitate sperm-derived DNA damage repair in mouse zygotes fertilized with oxygen-stressed sperm.

  9. High level of phospho-Chk1 is associated with skin tumors.

  10. Chk1 is essential for the developmental formation of murine epidermal melanocytes but hemizygosity has little permanent developmental consequence in this cell type

Cow (Bovine) Checkpoint Kinase 1 (CHEK1) interaction partners

  1. The Chk1 directly phosphorylates eNOS (Montrer NOS3 Protéines) Ser (Montrer SIGLEC1 Protéines)(1179) in response to UV irradiation, which is dependent on Hsp90 (Montrer HSP90 Protéines) interaction.

Profil protéine CHEK1

Profil protéine

The protein encoded by this gene belongs to the Ser/Thr protein kinase family. It is required for checkpoint mediated cell cycle arrest in response to DNA damage or the presence of unreplicated DNA. This protein acts to integrate signals from ATM and ATR, two cell cycle proteins involved in DNA damage responses, that also associate with chromatin in meiotic prophase I. Phosphorylation of CDC25A protein phosphatase by this protein is required for cells to delay cell cycle progression in response to double-strand DNA breaks. Several alternatively spliced transcript variants have been found for this gene.

Alternative names and synonyms associated with CHEK1

  • checkpoint kinase 1 (CHEK1)
  • serine/threonine-protein kinase chk1 (ANI_1_2436074)
  • serine/threonine-protein kinase chk1 (AOR_1_768154)
  • serine/threonine-protein kinase Chk1 (PTRG_04183)
  • serine/threonine-protein kinase chk1 (SJAG_01680)
  • serine/threonine-protein kinase chk1 (PAAG_04978)
  • serine/threonine-protein kinase chk1 (MCYG_03290)
  • serine/threonine-protein kinase chk1 (VDBG_03742)
  • checkpoint kinase 1 (chek1)
  • checkpoint kinase 1 (Chek1)
  • CHK1 checkpoint homolog (S. pombe) (chek1)
  • CHK1 checkpoint homolog (S. pombe) (CHEK1)
  • STT3, subunit of the oligosaccharyltransferase complex, homolog A (S. cerevisiae) (STT3A)
  • An08g10320 Protéine
  • AO090003000441 Protéine
  • C85740 Protéine
  • CHEK1 Protéine
  • Chk1 Protéine
  • id:ibd2720 Protéine
  • rad27 Protéine
  • zgc:56093 Protéine

Protein level used designations for Checkpoint Kinase 1 Protéines (CHEK1)

CHK1 checkpoint homolog , Serine/threonine-protein kinase Chk1-like protein , serine/threonine-protein kinase Chk1 , serine/threonine-protein kinase chk1 , Checkpoint, S. pombe, homolog of, 1 , Chk1-S , cell cycle checkpoint kinase , checkpoint kinase-1 , Chk1 checkpoint kinase , xChk1 , checkpoint kinase 1 homolog , rad27 homolog , 2720 , integral membrane protein 1

GENE ID SPECIES
100064353 Equus caballus
4983346 Aspergillus niger CBS 513.88
5991605 Aspergillus oryzae RIB40
6342420 Pyrenophora tritici-repentis Pt-1C-BFP
7049849 Schizosaccharomyces japonicus yFS275
9096078 Paracoccidioides sp. 'lutzii' Pb01
9230546 Arthroderma otae CBS 113480
9532482 Verticillium alfalfae VaMs.102
1111 Homo sapiens
398191 Xenopus laevis
609767 Canis lupus familiaris
12649 Mus musculus
140583 Rattus norvegicus
100511709 Sus scrofa
393162 Danio rerio
513678 Bos taurus
374260 Gallus gallus
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