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anti-Human RRM2B Anticorps:
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Human Polyclonal RRM2B Primary Antibody pour IHC - ABIN966974
Tanaka, Arakawa, Yamaguchi, Shiraishi, Fukuda, Matsui, Takei, Nakamura: A ribonucleotide reductase gene involved in a p53-dependent cell-cycle checkpoint for DNA damage. dans Nature 2000
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Human Polyclonal RRM2B Primary Antibody pour IHC - ABIN966975
Bechtel, Rosenfelder, Duda, Schmidt, Ernst, Wellenreuther, Mehrle, Schuster, Bahr, Blöcker, Heubner, Hoerlein, Michel, Wedler, Köhrer, Ottenwälder, Poustka, Wiemann, Schupp: The full-ORF clone resource of the German cDNA Consortium. dans BMC genomics 2008
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Human Monoclonal RRM2B Primary Antibody pour IF, ELISA - ABIN565482
Piao, Jin, Kim, Lee, Amatya, Hyun, Chang, You: Ribonucleotide reductase small subunit p53R2 suppresses MEK-ERK activity by binding to ERK kinase 2. dans Oncogene 2009
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RRM1 (Montrer RRM1 Anticorps)/RRM2B enzyme is capable of retaining activity in hypoxia and therefore is favored over RRM1 (Montrer RRM1 Anticorps)/RRM2 (Montrer RRM2 Anticorps) in order to preserve ongoing replication and avoid the accumulation of DNA damage in hypoxic cells.
p53R2 acts as a positive regulator of TrxR2 (Montrer TXNRD2 Anticorps) activity in mitochondria both under normal physiological conditions and during the cellular response to DNA damage
Silencing of both PYCR1 (Montrer PYCR1 Anticorps) and PYCR2 (Montrer PYCR2 Anticorps) completely abolished anti-oxidation activity of RRM2B, demonstrating a functional collaboration of these metabolic enzymes in response to oxidative stress.
A newly discovered role of E2F1 (Montrer E2F1 Anticorps) in the regulation of p53R2 expression in DNA damage response.
analysis of caspase (Montrer CASP3 Anticorps)-dependent degradation of human R2 and p53R2 small subunits
in Turkish population p53R2 genotype distributions between head and neck squamous epithelial cell cancer patients and control groups were not statistically significantly different.
Data indicate that forkhead transcription factorsF OXO3 directly bound to and transcriptionally activated the promoter of ribonucleotide reductase subunit RRM2B, and induced the expression of RRM2B at RNA and protein levels.
we found no support of the hypothesis that aberrations of RRM1 (Montrer RRM1 Anticorps) or RRM2B, neither individually nor in combination, are associated with an altered clinical outcome following chemotherapy.
Ribonucleotide reductase M2B inhibits cell migration and spreading by early growth response protein 1 (Montrer EGR1 Anticorps)-mediated phosphatase and tensin homolog (Montrer PTEN Anticorps)/Akt1 (Montrer AKT1 Anticorps) pathway in hepatocellular carcinoma.
RRM2B expression may discriminate cervical cancer phenotype and radiochemotherapy outcome
Rrm2b plays a crucial role in maintaining chromosomal stability and preventing chronic-inflammation-associated tumorigenesis.
Rrm2b deficiency caused higher rates of spontaneous mutation in the kidneys of Rrm2b-/- mice. p53R2 has a pivotal role in maintaining dNTP levels for repair of DNA in resting cells.
This gene encodes the small subunit of a p53-inducible ribonucleotide reductase. This heterotetrameric enzyme catalyzes the conversion of ribonucleoside diphosphates to deoxyribonucleoside diphosphates. The product of this reaction is necessary for DNA synthesis. Mutations in this gene have been associated with autosomal recessive mitochondrial DNA depletion syndrome, autosomal dominant progressive external ophthalmoplegia-5, and mitochondrial neurogastrointestinal encephalopathy. Alternatively spliced transcript variants have been described.
ribonucleotide reductase M2 B (TP53 inducible)
, ribonucleoside-diphosphate reductase subunit M2 B
, TP53-inducible ribonucleotide reductase M2 B
, p53-inducible ribonucleotide reductase small subunit 2 homolog
, p53-inducible ribonucleotide reductase small subunit 2 short form beta
, p53-inducible ribonucleotide reductase small subunit 2-like protein