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Human CDK2 Kit ELISA pour Sandwich ELISA - ABIN414862
Berenjian, Hu, Abedi-Valugerdi, Hassan, Bashir Hassan, Morein: The nanoparticulate Quillaja saponin KGI exerts anti-proliferative effects by down-regulation of cell cycle molecules in U937 and HL-60 human leukemia cells. dans Leukemia & lymphoma 2014
CDK2 phosphorylates polyQ-AR specifically at Ser (Montrer SIGLEC1 Kits ELISA)(96). Phosphorylation of polyQ-AR by CDK2 increased protein stabilization and toxicity and is negatively regulated by the adenylyl cyclase/protein kinase A signaling pathway in spinobulbar muscular atrophy.
Data show that Noxa (Montrer PMAIP1 Kits ELISA)-mediated MCL-1 (Montrer MCL1 Kits ELISA) phosphorylation and degradation is regulated by CDK2.
Residual Cdk1 (Montrer CDK1 Kits ELISA)/Cdk2 activity after DNA damage promotes cell senescence.
evidence that CDK1 (Montrer CDK1 Kits ELISA)/2 participate in the regulation of constitutive pre-mRNA splicing by EGF (Montrer EGF Kits ELISA) stimulation in MDA-MB-468 cells.
The upregulation of miR (Montrer MLXIP Kits ELISA)-302b reduced the expression of CDK2, and inhibited ERK (Montrer EPHB2 Kits ELISA) signaling pathway, thereby inhibiting cell proliferation and G1/S phase conversion rate.
High CDK2 expression is associated with breast cancer.
Here, we introduce a transcriptional signature to specifically track CDK2 activity. It responds to genetic and chemical perturbations in the CDK (Montrer CDK4 Kits ELISA)-RB-E2F (Montrer E2F1 Kits ELISA) axis, correlates with mitotic rate in vitro and in vivo and reacts rapidly to changes in CDK2 activity during cell cycle progression
Here, we found that centrosomal protein of 76 kDa (Cep76 (Montrer Cep76 Kits ELISA)), previously shown to restrain centriole amplification, interacts with cyclin-dependent kinase 2 (CDK2) and is a bona fide substrate of this kinase. Cep76 (Montrer Cep76 Kits ELISA) is preferentially phosphorylated by cyclin A (Montrer CCNA2 Kits ELISA)/CDK2 at a single site S83, and this event is crucial to suppress centriole amplification in S phase
The authors find that Spy1 (Montrer SPDYA Kits ELISA) confers structural changes to Cdk2 that obviate the requirement of Cdk (Montrer CDK4 Kits ELISA) activation loop phosphorylation.
CDK2 serves as an important nexus linking primary beta-cell dysfunction to progressive beta-cell mass deterioration in diabetes
evidence that cyclin A1 (Montrer CCNA1 Kits ELISA)-associated activity is a mediator of apoptosis and that cyclin A1 (Montrer CCNA1 Kits ELISA)/Cdk2 is sufficient to induce apoptosis
Ad-p21 inhibits RNV in OIR. A potential underlying mechanism for this may be that overexpression of p21 arrests the cell cycle at the G1- to S-phase transition via inhibition of CDK2 activity.
data indicate that the essential meiotic functions of Cdk2 depend on its kinase activity, without which the generation of haploid cells is disrupted, resulting in sterility of otherwise healthy animals
Testosterone is the positive regulator of hepatocyte cell cycle via cyclin E (Montrer CCNE1 Kits ELISA)/cdk2 promoting hepatocarcinogenesis.
This approach allowed us to determine the identity of cyclin E (Montrer CCNE1 Kits ELISA) protein partners, as well as phosphorylation substrates of cyclins E (cyclin (Montrer PCNA Kits ELISA) E1and cyclin E2 (Montrer CCNE2 Kits ELISA))and its associated kinase, Cdk2, in different mouse organs.
RingoA (Montrer SPDYA Kits ELISA) is an important activator of Cdk2 at meiotic telomeres.
Foxo3 (Montrer FOXO3 Kits ELISA) circular RNA retards cell cycle progression via forming ternary complexes with p21 and CDK2.
Results identify phosphorylation of CDK2 at tyrosine 160 as a gate-keeping mechanism for hepatocyte proliferation.
Sox2 (Montrer SOX2 Kits ELISA) phosphorylation by Cdk2 promotes the establishment but not the maintenance of the pluripotent state.
intestinal clock controls the expression of key cell cycle regulators, such as cdc2 (Montrer CDK1 Kits ELISA), wee1 (Montrer WEE1 Kits ELISA), p21 (Montrer CDKN1A Kits ELISA), PCNA (Montrer PCNA Kits ELISA) and cdk2, but only weakly influences cyclin B1 (Montrer CCNB1 Kits ELISA), cyclin B2 (Montrer CCNB2 Kits ELISA) and cyclin E1 (Montrer CCNE1 Kits ELISA) expression.
PI3-kinase (Montrer PIK3CA Kits ELISA) and Akt (Montrer AKT1 Kits ELISA) participate in insulin (Montrer INS Kits ELISA) stimulation of p34cdc2 (Montrer CDK1 Kits ELISA) activation in zebrafish oocyte with phosphodiesterase 3 as a potential downstream target.
an essential role for UHRF1 (Montrer UHRF1 Kits ELISA) phosphorylation by cyclin-dependent kinase 2/cyclin A2 (Montrer CCNA2 Kits ELISA) during early vertebrate development
cyclin D1 (Montrer CCND1 Kits ELISA), CDK2 and CDK4 (Montrer CDK4 Kits ELISA) are expressed in both caruncular and intercaruncular cells derived from both nonpregnant, and artificially inseminated cows on days 30 and 60 of gestation
our results indicate that an ATM (Montrer ATM Kits ELISA)-P53 (Montrer TP53 Kits ELISA)-P21 (Montrer CDKN1A Kits ELISA) DNA damage checkpoint is intact in the absence of CDK2; however, CDK2 is important for proper repair of the damaged DNA by either directly or indirectly influencing DNA repair-related gene expression.
The protein encoded by this gene is a member of the Ser/Thr protein kinase family. This protein kinase is highly similar to the gene products of S. cerevisiae cdc28, and S. pombe cdc2. It is a catalytic subunit of the cyclin-dependent protein kinase complex, whose activity is restricted to the G1-S phase, and essential for cell cycle G1/S phase transition. This protein associates with and regulated by the regulatory subunits of the complex including cyclin A or E, CDK inhibitor p21Cip1 (CDKN1A) and p27Kip1 (CDKN1B). Its activity is also regulated by its protein phosphorylation. Two alternatively spliced variants and multiple transcription initiation sites of this gene have been reported.
cdc2-related protein kinase
, cell devision kinase 2
, cell division protein kinase 2
, p33 protein kinase
, Cyclin-dependent kinase 2-interacting protein
, cyclin-dependent kinase 2 interacting protein
, cyclin-dependent kinase 2-interacting protein
, MGC84068 protein
, cyclin dependent kinase 2-alpha
, cyclin-dependent kinase 2
, CDC2 homolog Eg1 protein kinase
, Cell division protein kinase 2